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Fetuin-A is related to infarct size, left ventricular function and remodelling after acute STEMI.

Feistritzer HJ, Klug G, Reinstadler SJ, Gröber MT, Mair J, Kirchmair R, Henninger B, Franz WM, Metzler B - Open Heart (2015)

Bottom Line: Fetuin-A levels (median 568 µg/mL, IQR 478-763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05).According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months.In addition, it might be useful to identify patients at increased risk for adverse LV remodelling.

View Article: PubMed Central - PubMed

Affiliation: University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck , Innsbruck , Austria.

ABSTRACT

Objective: To investigate the relationship between plasma fetuin-A, an anti-inflammatory glycoprotein which might be involved in myocardial healing after acute infarction, and infarct size, left ventricular (LV) function and dimensions as well as the occurrence of adverse remodelling at 4 months after acute ST segment elevation myocardial infarction (STEMI).

Methods: In this single-centre prospective, observational study, 89 patients underwent cardiac MR within the first week and 4 months after mechanical reperfusion for first STEMI. Infarct size, LV function and dimensions were assessed at both time points. Fetuin-A levels were determined from blood samples drawn at a median of 49 h (IQR 30-59 h) after STEMI by an immunofluorescent assay.

Results: Fetuin-A levels (median 568 µg/mL, IQR 478-763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05). Moreover, fetuin-A was related to the increase in the end-diastolic volume index (r=-0.383, p<0.001). According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months.

Conclusions: Circulating fetuin-A at day 2 after STEMI is related to acute and chronic infarct size, LV function and dimensions. In addition, it might be useful to identify patients at increased risk for adverse LV remodelling.

No MeSH data available.


Related in: MedlinePlus

(A) Linear correlation of fetuin-A and left ventricular ejection fraction (LVEF) at 4 months. (B) Linear correlation of fetuin-A and end-diastolic volume index (EDVI) at 4 months.
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OPENHRT2015000244F1: (A) Linear correlation of fetuin-A and left ventricular ejection fraction (LVEF) at 4 months. (B) Linear correlation of fetuin-A and end-diastolic volume index (EDVI) at 4 months.

Mentions: Linear correlations of baseline fetuin-A concentrations and CMR characteristics are shown in table 4 and figure 1. Baseline fetuin-A levels did not differ significantly between patients presenting with or without late MVO (p=0.163). No significant difference in fetuin-A concentrations was detected between transmural and non-transmural infarcts (p=0.341).


Fetuin-A is related to infarct size, left ventricular function and remodelling after acute STEMI.

Feistritzer HJ, Klug G, Reinstadler SJ, Gröber MT, Mair J, Kirchmair R, Henninger B, Franz WM, Metzler B - Open Heart (2015)

(A) Linear correlation of fetuin-A and left ventricular ejection fraction (LVEF) at 4 months. (B) Linear correlation of fetuin-A and end-diastolic volume index (EDVI) at 4 months.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488888&req=5

OPENHRT2015000244F1: (A) Linear correlation of fetuin-A and left ventricular ejection fraction (LVEF) at 4 months. (B) Linear correlation of fetuin-A and end-diastolic volume index (EDVI) at 4 months.
Mentions: Linear correlations of baseline fetuin-A concentrations and CMR characteristics are shown in table 4 and figure 1. Baseline fetuin-A levels did not differ significantly between patients presenting with or without late MVO (p=0.163). No significant difference in fetuin-A concentrations was detected between transmural and non-transmural infarcts (p=0.341).

Bottom Line: Fetuin-A levels (median 568 µg/mL, IQR 478-763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05).According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months.In addition, it might be useful to identify patients at increased risk for adverse LV remodelling.

View Article: PubMed Central - PubMed

Affiliation: University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck , Innsbruck , Austria.

ABSTRACT

Objective: To investigate the relationship between plasma fetuin-A, an anti-inflammatory glycoprotein which might be involved in myocardial healing after acute infarction, and infarct size, left ventricular (LV) function and dimensions as well as the occurrence of adverse remodelling at 4 months after acute ST segment elevation myocardial infarction (STEMI).

Methods: In this single-centre prospective, observational study, 89 patients underwent cardiac MR within the first week and 4 months after mechanical reperfusion for first STEMI. Infarct size, LV function and dimensions were assessed at both time points. Fetuin-A levels were determined from blood samples drawn at a median of 49 h (IQR 30-59 h) after STEMI by an immunofluorescent assay.

Results: Fetuin-A levels (median 568 µg/mL, IQR 478-763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05). Moreover, fetuin-A was related to the increase in the end-diastolic volume index (r=-0.383, p<0.001). According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months.

Conclusions: Circulating fetuin-A at day 2 after STEMI is related to acute and chronic infarct size, LV function and dimensions. In addition, it might be useful to identify patients at increased risk for adverse LV remodelling.

No MeSH data available.


Related in: MedlinePlus