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Novel macromolecules derived from coumarin: synthesis and antioxidant activity.

Al-Amiery AA, Al-Majedy YK, Kadhum AA, Mohamad AB - Sci Rep (2015)

Bottom Line: The rational design of 4-hydroxycoumarins with tailor-made antioxidant activities is required nowadays due to the wide variety of pharmacologically significant, structurally interesting of coumarins and researcher orientation toward green chemistry and natural products.A simple and unique coumarins have been achieved by reaction of 4-hydroxycoumarin with aromatic aldehyde accompanied with the creation of a macromolecules have 2-aminothiazolidin-4-one.The scavenging abilities of new compounds against stable DPPH radical (DPPH•) and hydrogen peroxide were done and the results show that the compounds exhibited high antioxidant activates.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor 43000, Malaysia.

ABSTRACT
The rational design of 4-hydroxycoumarins with tailor-made antioxidant activities is required nowadays due to the wide variety of pharmacologically significant, structurally interesting of coumarins and researcher orientation toward green chemistry and natural products. A simple and unique coumarins have been achieved by reaction of 4-hydroxycoumarin with aromatic aldehyde accompanied with the creation of a macromolecules have 2-aminothiazolidin-4-one. The molecular structures of the compounds were characterized by the Fourier transformation infrared and Nuclear magnetic resonance spectroscopies, in addition to CHN analysis. The scavenging abilities of new compounds against stable DPPH radical (DPPH•) and hydrogen peroxide were done and the results show that the compounds exhibited high antioxidant activates.

No MeSH data available.


Related in: MedlinePlus

The postulated mechanism for compound (1) as antioxidant.
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f4: The postulated mechanism for compound (1) as antioxidant.

Mentions: Suggested mechanisms for the reaction of (1) as an antioxidant as shown in Fig. 4, that depends on the hydroxyl hydrogen atom the bolded one, whereas this atom was under the influence resonance effect. The tautomer’s play an important role in releasing of hydrogen, it can been seen from Fig. 4 that the benzyl carbon atom is under withdrawing of three groups, first one is the aryl group that has nitro group in para position that has the highest electron with drawing and the second, third groups are the carbonyls. The resonance effect of carbon-benzylic one- makes the release of hydrogen as a free radical easier.


Novel macromolecules derived from coumarin: synthesis and antioxidant activity.

Al-Amiery AA, Al-Majedy YK, Kadhum AA, Mohamad AB - Sci Rep (2015)

The postulated mechanism for compound (1) as antioxidant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488837&req=5

f4: The postulated mechanism for compound (1) as antioxidant.
Mentions: Suggested mechanisms for the reaction of (1) as an antioxidant as shown in Fig. 4, that depends on the hydroxyl hydrogen atom the bolded one, whereas this atom was under the influence resonance effect. The tautomer’s play an important role in releasing of hydrogen, it can been seen from Fig. 4 that the benzyl carbon atom is under withdrawing of three groups, first one is the aryl group that has nitro group in para position that has the highest electron with drawing and the second, third groups are the carbonyls. The resonance effect of carbon-benzylic one- makes the release of hydrogen as a free radical easier.

Bottom Line: The rational design of 4-hydroxycoumarins with tailor-made antioxidant activities is required nowadays due to the wide variety of pharmacologically significant, structurally interesting of coumarins and researcher orientation toward green chemistry and natural products.A simple and unique coumarins have been achieved by reaction of 4-hydroxycoumarin with aromatic aldehyde accompanied with the creation of a macromolecules have 2-aminothiazolidin-4-one.The scavenging abilities of new compounds against stable DPPH radical (DPPH•) and hydrogen peroxide were done and the results show that the compounds exhibited high antioxidant activates.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor 43000, Malaysia.

ABSTRACT
The rational design of 4-hydroxycoumarins with tailor-made antioxidant activities is required nowadays due to the wide variety of pharmacologically significant, structurally interesting of coumarins and researcher orientation toward green chemistry and natural products. A simple and unique coumarins have been achieved by reaction of 4-hydroxycoumarin with aromatic aldehyde accompanied with the creation of a macromolecules have 2-aminothiazolidin-4-one. The molecular structures of the compounds were characterized by the Fourier transformation infrared and Nuclear magnetic resonance spectroscopies, in addition to CHN analysis. The scavenging abilities of new compounds against stable DPPH radical (DPPH•) and hydrogen peroxide were done and the results show that the compounds exhibited high antioxidant activates.

No MeSH data available.


Related in: MedlinePlus