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Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment.

Shen L, Ji HF - Nutrients (2015)

Bottom Line: Pooled data showed that subjects with deficient and insufficient vitamin D levels had increased PD risks compared with matched-controls according to the corresponding OR: 2.08, 95% CI: 1.63 to 2.65, and 1.29, 95% CI: 1.10 to 1.51.Vitamin D supplementation was associated with significantly reduced risk of PD (OR: 0.62, 95% CI: 0.35 to 0.90).Outdoor work was also related to reduced risk of PD (OR: 0.72, 95% CI: 0.63 to 0.81).

View Article: PubMed Central - PubMed

Affiliation: Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China. shen@sdut.edu.cn.

ABSTRACT
The present study aimed to quantitatively assess the associations between vitamin D and Parkinson's Disease (PD) risks, which include: (i) risk of PD in subjects with deficient and insufficient vitamin D levels; (ii) association between vitamin D supplementation and risk of PD; and (iii) association between outdoor work and PD risk, through meta-analyzing available data. An electronic literature search supplemented by hand searching up to March 2015 identified seven eligible studies comprising 5690 PD patients and 21251 matched controls. Odds ratio (OR) and 95% confidence interval (CI) of PD risk were assessed through pooling the collected data from eligible studies using Stata software. Pooled data showed that subjects with deficient and insufficient vitamin D levels had increased PD risks compared with matched-controls according to the corresponding OR: 2.08, 95% CI: 1.63 to 2.65, and 1.29, 95% CI: 1.10 to 1.51. Vitamin D supplementation was associated with significantly reduced risk of PD (OR: 0.62, 95% CI: 0.35 to 0.90). Outdoor work was also related to reduced risk of PD (OR: 0.72, 95% CI: 0.63 to 0.81). The findings may stimulate larger, well-designed studies to further verify the associations between vitamin D and PD risk.

No MeSH data available.


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Forest plots of deficient and insufficient vitamin D levels and risk of Parkinson’s Disease (PD).
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nutrients-07-04817-f002: Forest plots of deficient and insufficient vitamin D levels and risk of Parkinson’s Disease (PD).

Mentions: Three studies covering 966 PD patients and 813 age-matched controls were included in the quantitative analysis of vitamin D level and risk of PD [15,16,17]. Main descriptive data from the studies are shown in Table 1. Results of the meta-analysis revealed that low vitamin D level was associated with significantly increased risk of PD overall according to the OR: 1.50, 95% CI: 1.31 to 1.71. Vitamin D deficient individuals (serum 25(OH)D level <50 nmol/L) had a two-fold increased risk of PD in comparison with controls OR: 2.08, 95% CI: 1.63 to 2.65, and vitamin D insufficient individuals (serum 25(OH)D level <75 nmol/L) experienced a 30% increased risk of PD compared with controls (OR: 1.29, 95% CI: 1.10 to 1.51) (Figure 2). There was no evidence for significant statistical heterogeneity between the eligible studies.


Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment.

Shen L, Ji HF - Nutrients (2015)

Forest plots of deficient and insufficient vitamin D levels and risk of Parkinson’s Disease (PD).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488816&req=5

nutrients-07-04817-f002: Forest plots of deficient and insufficient vitamin D levels and risk of Parkinson’s Disease (PD).
Mentions: Three studies covering 966 PD patients and 813 age-matched controls were included in the quantitative analysis of vitamin D level and risk of PD [15,16,17]. Main descriptive data from the studies are shown in Table 1. Results of the meta-analysis revealed that low vitamin D level was associated with significantly increased risk of PD overall according to the OR: 1.50, 95% CI: 1.31 to 1.71. Vitamin D deficient individuals (serum 25(OH)D level <50 nmol/L) had a two-fold increased risk of PD in comparison with controls OR: 2.08, 95% CI: 1.63 to 2.65, and vitamin D insufficient individuals (serum 25(OH)D level <75 nmol/L) experienced a 30% increased risk of PD compared with controls (OR: 1.29, 95% CI: 1.10 to 1.51) (Figure 2). There was no evidence for significant statistical heterogeneity between the eligible studies.

Bottom Line: Pooled data showed that subjects with deficient and insufficient vitamin D levels had increased PD risks compared with matched-controls according to the corresponding OR: 2.08, 95% CI: 1.63 to 2.65, and 1.29, 95% CI: 1.10 to 1.51.Vitamin D supplementation was associated with significantly reduced risk of PD (OR: 0.62, 95% CI: 0.35 to 0.90).Outdoor work was also related to reduced risk of PD (OR: 0.72, 95% CI: 0.63 to 0.81).

View Article: PubMed Central - PubMed

Affiliation: Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China. shen@sdut.edu.cn.

ABSTRACT
The present study aimed to quantitatively assess the associations between vitamin D and Parkinson's Disease (PD) risks, which include: (i) risk of PD in subjects with deficient and insufficient vitamin D levels; (ii) association between vitamin D supplementation and risk of PD; and (iii) association between outdoor work and PD risk, through meta-analyzing available data. An electronic literature search supplemented by hand searching up to March 2015 identified seven eligible studies comprising 5690 PD patients and 21251 matched controls. Odds ratio (OR) and 95% confidence interval (CI) of PD risk were assessed through pooling the collected data from eligible studies using Stata software. Pooled data showed that subjects with deficient and insufficient vitamin D levels had increased PD risks compared with matched-controls according to the corresponding OR: 2.08, 95% CI: 1.63 to 2.65, and 1.29, 95% CI: 1.10 to 1.51. Vitamin D supplementation was associated with significantly reduced risk of PD (OR: 0.62, 95% CI: 0.35 to 0.90). Outdoor work was also related to reduced risk of PD (OR: 0.72, 95% CI: 0.63 to 0.81). The findings may stimulate larger, well-designed studies to further verify the associations between vitamin D and PD risk.

No MeSH data available.


Related in: MedlinePlus