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PON1 and Mediterranean Diet.

Lou-Bonafonte JM, Gabás-Rivera C, Navarro MA, Osada J - Nutrients (2015)

Bottom Line: Extra virgin olive oil, the main source of fat, has been particularly effective in increasing PON1 activity, an action that could be due to low saturated fatty acid intake, oleic acid enrichment of phospholipids present in high-density lipoproteins that favor the activity, and increasing hepatic PON1 mRNA and protein expressions induced by minor components present in this oil.Other Mediterranean diet constituents, such as nuts, fruits and vegetables, have been effective in modulating the activity of the enzyme, pomegranate and its compounds being the best characterized items.Ongoing research on compounds isolated from all these natural products, mainly phenolic compounds and carotenoids, indicates that some of them are particularly effective, and this may enhance the use of nutraceuticals and functional foods capable of potentiating PON1 activity.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Farmacología y Fisiología, Facultad de Ciencias de la Salud y del Deporte, Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza, Huesca, E-22002, Spain. mlou@unizar.es.

ABSTRACT
The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases. Paraoxonase 1 (PON1) has been implicated in the development of those conditions, especially atherosclerosis. The present work describes a systematic review of current evidence supporting the influence of Mediterranean diet and its constituents on this enzyme. Despite the differential response of some genetic polymorphisms, the Mediterranean diet has been shown to exert a protective action on this enzyme. Extra virgin olive oil, the main source of fat, has been particularly effective in increasing PON1 activity, an action that could be due to low saturated fatty acid intake, oleic acid enrichment of phospholipids present in high-density lipoproteins that favor the activity, and increasing hepatic PON1 mRNA and protein expressions induced by minor components present in this oil. Other Mediterranean diet constituents, such as nuts, fruits and vegetables, have been effective in modulating the activity of the enzyme, pomegranate and its compounds being the best characterized items. Ongoing research on compounds isolated from all these natural products, mainly phenolic compounds and carotenoids, indicates that some of them are particularly effective, and this may enhance the use of nutraceuticals and functional foods capable of potentiating PON1 activity.

No MeSH data available.


Related in: MedlinePlus

Effect of dietary components on regulation of paraoxonase 1 activity and its interaction with genetic factors. Adapted from [12] and [13], reproduced with permission from Elsevier.
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nutrients-07-04068-f002: Effect of dietary components on regulation of paraoxonase 1 activity and its interaction with genetic factors. Adapted from [12] and [13], reproduced with permission from Elsevier.

Mentions: The interindividual variation in PON1 activity is partly determined by the existence of genetic polymorphisms since human PON1 shows two major polymorphic isoforms, PON1-Q192R and PON1-L55M. The PON1-192 polymorphism is associated with diminished PON1 concentrations and an increased risk for coronary heart disease in RR-allele subjects [10]. PON1 L55M genotype (MM) frequency was significantly higher in those patients than in controls [11]. PON1 activity can be modulated by environmental conditions as well (Figure 2).


PON1 and Mediterranean Diet.

Lou-Bonafonte JM, Gabás-Rivera C, Navarro MA, Osada J - Nutrients (2015)

Effect of dietary components on regulation of paraoxonase 1 activity and its interaction with genetic factors. Adapted from [12] and [13], reproduced with permission from Elsevier.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488773&req=5

nutrients-07-04068-f002: Effect of dietary components on regulation of paraoxonase 1 activity and its interaction with genetic factors. Adapted from [12] and [13], reproduced with permission from Elsevier.
Mentions: The interindividual variation in PON1 activity is partly determined by the existence of genetic polymorphisms since human PON1 shows two major polymorphic isoforms, PON1-Q192R and PON1-L55M. The PON1-192 polymorphism is associated with diminished PON1 concentrations and an increased risk for coronary heart disease in RR-allele subjects [10]. PON1 L55M genotype (MM) frequency was significantly higher in those patients than in controls [11]. PON1 activity can be modulated by environmental conditions as well (Figure 2).

Bottom Line: Extra virgin olive oil, the main source of fat, has been particularly effective in increasing PON1 activity, an action that could be due to low saturated fatty acid intake, oleic acid enrichment of phospholipids present in high-density lipoproteins that favor the activity, and increasing hepatic PON1 mRNA and protein expressions induced by minor components present in this oil.Other Mediterranean diet constituents, such as nuts, fruits and vegetables, have been effective in modulating the activity of the enzyme, pomegranate and its compounds being the best characterized items.Ongoing research on compounds isolated from all these natural products, mainly phenolic compounds and carotenoids, indicates that some of them are particularly effective, and this may enhance the use of nutraceuticals and functional foods capable of potentiating PON1 activity.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Farmacología y Fisiología, Facultad de Ciencias de la Salud y del Deporte, Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza, Huesca, E-22002, Spain. mlou@unizar.es.

ABSTRACT
The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases. Paraoxonase 1 (PON1) has been implicated in the development of those conditions, especially atherosclerosis. The present work describes a systematic review of current evidence supporting the influence of Mediterranean diet and its constituents on this enzyme. Despite the differential response of some genetic polymorphisms, the Mediterranean diet has been shown to exert a protective action on this enzyme. Extra virgin olive oil, the main source of fat, has been particularly effective in increasing PON1 activity, an action that could be due to low saturated fatty acid intake, oleic acid enrichment of phospholipids present in high-density lipoproteins that favor the activity, and increasing hepatic PON1 mRNA and protein expressions induced by minor components present in this oil. Other Mediterranean diet constituents, such as nuts, fruits and vegetables, have been effective in modulating the activity of the enzyme, pomegranate and its compounds being the best characterized items. Ongoing research on compounds isolated from all these natural products, mainly phenolic compounds and carotenoids, indicates that some of them are particularly effective, and this may enhance the use of nutraceuticals and functional foods capable of potentiating PON1 activity.

No MeSH data available.


Related in: MedlinePlus