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A novel Peptide-binding motifs inference approach to understand deoxynivalenol molecular toxicity.

Hassan YI, Watts C, Li XZ, Zhou T - Toxins (Basel) (2015)

Bottom Line: Deoxynivalenol (DON) is a type B trichothecene mycotoxin that is commonly detected in cereals and grains world-wide.The low-tolerated levels of this mycotoxin, especially in mono-gastric animals, reflect its bio-potency.The toxicity of DON is conventionally attributed to its ability to inhibit ribosomal protein biosynthesis, but recent advances in molecular tools have elucidated novel mechanisms that further explain DON's toxicological profile, complementing the diverse symptoms associated with its exposure.

View Article: PubMed Central - PubMed

Affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, Canada. yousef.hassan@agr.gc.ca.

ABSTRACT
Deoxynivalenol (DON) is a type B trichothecene mycotoxin that is commonly detected in cereals and grains world-wide. The low-tolerated levels of this mycotoxin, especially in mono-gastric animals, reflect its bio-potency. The toxicity of DON is conventionally attributed to its ability to inhibit ribosomal protein biosynthesis, but recent advances in molecular tools have elucidated novel mechanisms that further explain DON's toxicological profile, complementing the diverse symptoms associated with its exposure. This article summarizes the recent findings related to novel mechanisms of DON toxicity as well as how structural modifications to DON alter its potency. In addition, it explores feasible ways of expanding our understating of DON-cellular targets and their roles in DON toxicity, clearance, and detoxification through the utilization of computational biology approaches.

No MeSH data available.


Related in: MedlinePlus

Type B trichothecenes are characterized by a carbonyl group at C-8. In comparison, type A trichothecene mycotoxins may have an –H, –OH, or –OAcyl group at C-8, while type D lack functional groups at C-8 and possess a complex linkage from C-4 to C-15.
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toxins-07-01989-f002: Type B trichothecenes are characterized by a carbonyl group at C-8. In comparison, type A trichothecene mycotoxins may have an –H, –OH, or –OAcyl group at C-8, while type D lack functional groups at C-8 and possess a complex linkage from C-4 to C-15.

Mentions: Finally, and in regards to the ectodomain shedding of TNF receptor 1, which DON was reported to elicit; 3ADON was found also to possess the same capability; although, this response was associated with much higher 3ADON levels (1 μM for DON in comparison to greater than 10 μM for 3ADON) [31]. It should be noted that neither type A (e.g., T-2 toxin) nor type D (e.g., verrucarin A) trichothecenes that were tested in this study were able to cause similar inhibition, suggesting that the C-8 carbonyl group which differentiates type B trichothecenes (Figure 2), such as DON and 3ADON, from other sub-groups may be important for this specific MAPK pathway [31].


A novel Peptide-binding motifs inference approach to understand deoxynivalenol molecular toxicity.

Hassan YI, Watts C, Li XZ, Zhou T - Toxins (Basel) (2015)

Type B trichothecenes are characterized by a carbonyl group at C-8. In comparison, type A trichothecene mycotoxins may have an –H, –OH, or –OAcyl group at C-8, while type D lack functional groups at C-8 and possess a complex linkage from C-4 to C-15.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488686&req=5

toxins-07-01989-f002: Type B trichothecenes are characterized by a carbonyl group at C-8. In comparison, type A trichothecene mycotoxins may have an –H, –OH, or –OAcyl group at C-8, while type D lack functional groups at C-8 and possess a complex linkage from C-4 to C-15.
Mentions: Finally, and in regards to the ectodomain shedding of TNF receptor 1, which DON was reported to elicit; 3ADON was found also to possess the same capability; although, this response was associated with much higher 3ADON levels (1 μM for DON in comparison to greater than 10 μM for 3ADON) [31]. It should be noted that neither type A (e.g., T-2 toxin) nor type D (e.g., verrucarin A) trichothecenes that were tested in this study were able to cause similar inhibition, suggesting that the C-8 carbonyl group which differentiates type B trichothecenes (Figure 2), such as DON and 3ADON, from other sub-groups may be important for this specific MAPK pathway [31].

Bottom Line: Deoxynivalenol (DON) is a type B trichothecene mycotoxin that is commonly detected in cereals and grains world-wide.The low-tolerated levels of this mycotoxin, especially in mono-gastric animals, reflect its bio-potency.The toxicity of DON is conventionally attributed to its ability to inhibit ribosomal protein biosynthesis, but recent advances in molecular tools have elucidated novel mechanisms that further explain DON's toxicological profile, complementing the diverse symptoms associated with its exposure.

View Article: PubMed Central - PubMed

Affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, Canada. yousef.hassan@agr.gc.ca.

ABSTRACT
Deoxynivalenol (DON) is a type B trichothecene mycotoxin that is commonly detected in cereals and grains world-wide. The low-tolerated levels of this mycotoxin, especially in mono-gastric animals, reflect its bio-potency. The toxicity of DON is conventionally attributed to its ability to inhibit ribosomal protein biosynthesis, but recent advances in molecular tools have elucidated novel mechanisms that further explain DON's toxicological profile, complementing the diverse symptoms associated with its exposure. This article summarizes the recent findings related to novel mechanisms of DON toxicity as well as how structural modifications to DON alter its potency. In addition, it explores feasible ways of expanding our understating of DON-cellular targets and their roles in DON toxicity, clearance, and detoxification through the utilization of computational biology approaches.

No MeSH data available.


Related in: MedlinePlus