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Development of myenteric plexus in human foetuses: a quantitative study.

Singh S, Shariff A, Roy T, Das T, Rani N - Anat Cell Biol (2015)

Bottom Line: This study revealed that the maturational event increases after 17WG and extensive innervations is established at 23WG.During prenatal life there is an increase in the neuronal cell size from 14-23WG signifying maturational process.Such studies are essential for clinicians and surgeons to correlate the normal and pathologic development of the enteric nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

ABSTRACT
Maturation of neurons of the myenteric plexus (MP) of human fetal sigmoid colon was studied at various weeks of gestation (WG). There is abundant literature on the development of MP in various segments of the gut but there are fewer reports on the development of MP in human sigmoid colon which is a site of various disorders. Sigmoid colonic segments from 12 aborted foetuses aged 14-23WG were processed for NADPH histochemistry. Stereologic evaluation of the neuronal cell profiles, numerical density, number of neurons per ganglion and myenteric fraction was conducted using using imageJ software. According to gestational age, foetuses were assigned into two groups (group 1 [n=7], less than <17WG and group 2 [n=5], more than >17WG). The overall size of neuronal cell profiles in the MP was significantly increased (P<0.05). The numerical density of neurons decreased in group 2 in comparison to group 1, the number of neurons per ganglion and myenteric fraction were increased in group 2 but all these were not statistically significant. This study revealed that the maturational event increases after 17WG and extensive innervations is established at 23WG. During prenatal life there is an increase in the neuronal cell size from 14-23WG signifying maturational process. Such studies are essential for clinicians and surgeons to correlate the normal and pathologic development of the enteric nervous system.

No MeSH data available.


Related in: MedlinePlus

All the parameters (area, perimeter and ferret diameter) which were taken to assess the overall size of the neuronal cell in the myenteric plexus were significantly increased (P=0.02). WG, weeks of gestation; group 1, <17WG; group 2, >17WG. *Statistically significant.
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Figure 3: All the parameters (area, perimeter and ferret diameter) which were taken to assess the overall size of the neuronal cell in the myenteric plexus were significantly increased (P=0.02). WG, weeks of gestation; group 1, <17WG; group 2, >17WG. *Statistically significant.

Mentions: The morphometric data of the nitrergic neuronal cell profiles in both the groups were compared. It included the following parameters: mean area, perimeter, and feret diameter of the diaphorase positive neuronal cells. The average area of neuronal cells in group 1 was 57.31±4.66 µm2 and in group 2 it was 109.85±23.14 µm2 respectively. The perimeter of the neuronal cells in group 1 was 30.31±1.43 µm, and in the group 2 it was 41±3.73 µm respectively. The maximum diameter or feret diameter in group 1 was 11.81±0.62 µm and in group 2 it was 15.80±1.30 µm. Thus, all the parameters which were taken to assess the overall size of the neuronal cell in the MP were significantly increased (P=0.024) (Table 1, Fig. 3).


Development of myenteric plexus in human foetuses: a quantitative study.

Singh S, Shariff A, Roy T, Das T, Rani N - Anat Cell Biol (2015)

All the parameters (area, perimeter and ferret diameter) which were taken to assess the overall size of the neuronal cell in the myenteric plexus were significantly increased (P=0.02). WG, weeks of gestation; group 1, <17WG; group 2, >17WG. *Statistically significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488640&req=5

Figure 3: All the parameters (area, perimeter and ferret diameter) which were taken to assess the overall size of the neuronal cell in the myenteric plexus were significantly increased (P=0.02). WG, weeks of gestation; group 1, <17WG; group 2, >17WG. *Statistically significant.
Mentions: The morphometric data of the nitrergic neuronal cell profiles in both the groups were compared. It included the following parameters: mean area, perimeter, and feret diameter of the diaphorase positive neuronal cells. The average area of neuronal cells in group 1 was 57.31±4.66 µm2 and in group 2 it was 109.85±23.14 µm2 respectively. The perimeter of the neuronal cells in group 1 was 30.31±1.43 µm, and in the group 2 it was 41±3.73 µm respectively. The maximum diameter or feret diameter in group 1 was 11.81±0.62 µm and in group 2 it was 15.80±1.30 µm. Thus, all the parameters which were taken to assess the overall size of the neuronal cell in the MP were significantly increased (P=0.024) (Table 1, Fig. 3).

Bottom Line: This study revealed that the maturational event increases after 17WG and extensive innervations is established at 23WG.During prenatal life there is an increase in the neuronal cell size from 14-23WG signifying maturational process.Such studies are essential for clinicians and surgeons to correlate the normal and pathologic development of the enteric nervous system.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

ABSTRACT
Maturation of neurons of the myenteric plexus (MP) of human fetal sigmoid colon was studied at various weeks of gestation (WG). There is abundant literature on the development of MP in various segments of the gut but there are fewer reports on the development of MP in human sigmoid colon which is a site of various disorders. Sigmoid colonic segments from 12 aborted foetuses aged 14-23WG were processed for NADPH histochemistry. Stereologic evaluation of the neuronal cell profiles, numerical density, number of neurons per ganglion and myenteric fraction was conducted using using imageJ software. According to gestational age, foetuses were assigned into two groups (group 1 [n=7], less than <17WG and group 2 [n=5], more than >17WG). The overall size of neuronal cell profiles in the MP was significantly increased (P<0.05). The numerical density of neurons decreased in group 2 in comparison to group 1, the number of neurons per ganglion and myenteric fraction were increased in group 2 but all these were not statistically significant. This study revealed that the maturational event increases after 17WG and extensive innervations is established at 23WG. During prenatal life there is an increase in the neuronal cell size from 14-23WG signifying maturational process. Such studies are essential for clinicians and surgeons to correlate the normal and pathologic development of the enteric nervous system.

No MeSH data available.


Related in: MedlinePlus