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Seasonality of Pneumococcal Nasopharyngeal Carriage in Rural Gambia Determined within the Context of a Cluster Randomized Pneumococcal Vaccine Trial.

Bojang A, Jafali J, Egere UE, Hill PC, Antonio M, Jeffries D, Greenwood BM, Roca A - PLoS ONE (2015)

Bottom Line: Prevalence of pneumococcal nasopharyngeal carriage in the study subjects (median age 11 years) was 55.0%; this prevalence decreased linearly with increasing age (p = 0.001).Prevalence of carriage was significantly higher during the dry than the rainy season for any pneumococcal carriage [57.6% versus 47.8% (p<0.001)], pneumococcal vaccine serotype carriage [10.3% versus 6.5% (p< 0.001)] and non-vaccine serotype carriage [49.7% versus 42.7% (p<0.001)].Differences remained significant in the adjusted analysis.

View Article: PubMed Central - PubMed

Affiliation: Medical Research Council Unit, Fajara, The Gambia.

ABSTRACT

Background: We conducted an ancillary study among individuals who had participated in a PCV-7 trial in rural Gambia, to determine the influence of season on the prevalence of pneumococcal carriage.

Methods: 636 individuals above 30 months of age were followed from 4 to 20 months after vaccination with PCV-7 or meningococcal-conjugate-vaccine. Nasopharyngeal swabs were collected periodically between November 2006 and June 2008. Overall, 4,495 NPS were collected.

Results: Prevalence of pneumococcal nasopharyngeal carriage in the study subjects (median age 11 years) was 55.0%; this prevalence decreased linearly with increasing age (p = 0.001). Prevalence of carriage was significantly higher during the dry than the rainy season for any pneumococcal carriage [57.6% versus 47.8% (p<0.001)], pneumococcal vaccine serotype carriage [10.3% versus 6.5% (p< 0.001)] and non-vaccine serotype carriage [49.7% versus 42.7% (p<0.001)]. Differences remained significant in the adjusted analysis.

Conclusions: In areas of Africa with marked variation in rainfall, seasonality of pneumococcal carriage needs to be considered when interpreting carriage data.

No MeSH data available.


Prevalence of nasopharyngeal carriage in dry and rainy seasons in the study villages by age group for the different study endpoints.
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pone.0129649.g002: Prevalence of nasopharyngeal carriage in dry and rainy seasons in the study villages by age group for the different study endpoints.

Mentions: In the unadjusted analyses, prevalence of pneumococcal carriage was significantly higher during the dry season than during the rainy season for Any carriage [57.6% versus 47.8%, OR = 1.48 95%CI(1.30;1.69), p<0.001], for VT carriage [10.3% versus 6.5%, OR = 1.64 95%CI(1.27;2.12), p<0.001] and for NVT carriage [49.7% versus 42.7%, OR = 1.32 95%CI(1.16;1.51), p< 0.001]. The same trend of higher prevalence of pneumococcal carriage during the dry season was observed in all age groups (Fig 2 and Fig 3).


Seasonality of Pneumococcal Nasopharyngeal Carriage in Rural Gambia Determined within the Context of a Cluster Randomized Pneumococcal Vaccine Trial.

Bojang A, Jafali J, Egere UE, Hill PC, Antonio M, Jeffries D, Greenwood BM, Roca A - PLoS ONE (2015)

Prevalence of nasopharyngeal carriage in dry and rainy seasons in the study villages by age group for the different study endpoints.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488590&req=5

pone.0129649.g002: Prevalence of nasopharyngeal carriage in dry and rainy seasons in the study villages by age group for the different study endpoints.
Mentions: In the unadjusted analyses, prevalence of pneumococcal carriage was significantly higher during the dry season than during the rainy season for Any carriage [57.6% versus 47.8%, OR = 1.48 95%CI(1.30;1.69), p<0.001], for VT carriage [10.3% versus 6.5%, OR = 1.64 95%CI(1.27;2.12), p<0.001] and for NVT carriage [49.7% versus 42.7%, OR = 1.32 95%CI(1.16;1.51), p< 0.001]. The same trend of higher prevalence of pneumococcal carriage during the dry season was observed in all age groups (Fig 2 and Fig 3).

Bottom Line: Prevalence of pneumococcal nasopharyngeal carriage in the study subjects (median age 11 years) was 55.0%; this prevalence decreased linearly with increasing age (p = 0.001).Prevalence of carriage was significantly higher during the dry than the rainy season for any pneumococcal carriage [57.6% versus 47.8% (p<0.001)], pneumococcal vaccine serotype carriage [10.3% versus 6.5% (p< 0.001)] and non-vaccine serotype carriage [49.7% versus 42.7% (p<0.001)].Differences remained significant in the adjusted analysis.

View Article: PubMed Central - PubMed

Affiliation: Medical Research Council Unit, Fajara, The Gambia.

ABSTRACT

Background: We conducted an ancillary study among individuals who had participated in a PCV-7 trial in rural Gambia, to determine the influence of season on the prevalence of pneumococcal carriage.

Methods: 636 individuals above 30 months of age were followed from 4 to 20 months after vaccination with PCV-7 or meningococcal-conjugate-vaccine. Nasopharyngeal swabs were collected periodically between November 2006 and June 2008. Overall, 4,495 NPS were collected.

Results: Prevalence of pneumococcal nasopharyngeal carriage in the study subjects (median age 11 years) was 55.0%; this prevalence decreased linearly with increasing age (p = 0.001). Prevalence of carriage was significantly higher during the dry than the rainy season for any pneumococcal carriage [57.6% versus 47.8% (p<0.001)], pneumococcal vaccine serotype carriage [10.3% versus 6.5% (p< 0.001)] and non-vaccine serotype carriage [49.7% versus 42.7% (p<0.001)]. Differences remained significant in the adjusted analysis.

Conclusions: In areas of Africa with marked variation in rainfall, seasonality of pneumococcal carriage needs to be considered when interpreting carriage data.

No MeSH data available.