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Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy.

Gnabre J, Bates R, Huang RC - J Tradit Complement Med (2015)

Bottom Line: Some of these activities, namely antiherpes, antioxidant, antifungal, and anti-inflammatory, were known a century ago.Molecular mechanisms underlying the antiviral and anticancer activities have been elucidated and involve the inhibition of SP1 dependent gene transcription.We introduce the concept of a cocktail of safe well-characterized natural products from the creosote bush that would represent a bridge between oriental herbal medicines and Western drug-based therapies.

View Article: PubMed Central - PubMed

Affiliation: Mal-4 Research Institute, Baltimore, MD, USA.

ABSTRACT
The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (Larrea tridentata), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern North America and the Amerindians from South America. The plant is rich in simple bisphenyl lignans and tricyclic lignans known as cyclolignans. These compounds are responsible for many of the pharmacological activities of extracts of the plants. Some of these activities, namely antiherpes, antioxidant, antifungal, and anti-inflammatory, were known a century ago. Only recently have further studies revealed other crucial activities of the same plant molecules as powerful agents against human immunodeficiency virus, human papillomavirus, cancer, neurodegenerative diseases, and symptoms of aging. Molecular mechanisms underlying the antiviral and anticancer activities have been elucidated and involve the inhibition of SP1 dependent gene transcription. This review summarizes the recent findings on creosote bush lignans. We introduce the concept of a cocktail of safe well-characterized natural products from the creosote bush that would represent a bridge between oriental herbal medicines and Western drug-based therapies.

No MeSH data available.


Related in: MedlinePlus

Important methylated lignans from creosote bush of medical relevance: Antiviral 3′-O-methyl nordihydroguaiaretic acid (Mal-4) and anticancer tetra-O-methylnordihydroquaiaretic acid (M4N). Other lignans isolated from the creosote bush also possess antiviral and anticancer activities.
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fig3: Important methylated lignans from creosote bush of medical relevance: Antiviral 3′-O-methyl nordihydroguaiaretic acid (Mal-4) and anticancer tetra-O-methylnordihydroquaiaretic acid (M4N). Other lignans isolated from the creosote bush also possess antiviral and anticancer activities.

Mentions: Methylated derivatives of NDGA, such as 3′-O-methyl-NDGA (Mal-4), and other lignans with various degrees of O-methylation, were first shown to possess activity against HIV in the mid-1990s.15 Mal-4 is a yellowish oil that is highly active and readily permeates cell membranes and viral coat layers. Likewise, the dimethoxy and trimethoxy derivatives are oily and active. These activities were also observed with O-methylated cyclolignans isolated from the same plant extract. Unlike NDGA, all these compounds were effective at inhibiting HIV replication in cell cultures (laboratory strains as well as primary isolates from AIDS patients).21 The cyclolignans 3′-demethoxyisoguaiacin and norisoguaiacin (Fig. 2B), also isolated from creosote bush, were significantly more active than all NDGA derivatives including Mal-4.15 However, these compounds occur in much smaller amounts in the extract compared to NDGA and its analogs. Full synthetic methylation of NDGA yielded the tetramethylated derivative terameprocol (M4N; Fig. 3B), which has advanced to clinical trials as an anticancer agent.22 M4N is an amorphous powder that naturally occurs in the plant, but in much lower concentration than NDGA and many NDGA derivatives.


Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy.

Gnabre J, Bates R, Huang RC - J Tradit Complement Med (2015)

Important methylated lignans from creosote bush of medical relevance: Antiviral 3′-O-methyl nordihydroguaiaretic acid (Mal-4) and anticancer tetra-O-methylnordihydroquaiaretic acid (M4N). Other lignans isolated from the creosote bush also possess antiviral and anticancer activities.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488564&req=5

fig3: Important methylated lignans from creosote bush of medical relevance: Antiviral 3′-O-methyl nordihydroguaiaretic acid (Mal-4) and anticancer tetra-O-methylnordihydroquaiaretic acid (M4N). Other lignans isolated from the creosote bush also possess antiviral and anticancer activities.
Mentions: Methylated derivatives of NDGA, such as 3′-O-methyl-NDGA (Mal-4), and other lignans with various degrees of O-methylation, were first shown to possess activity against HIV in the mid-1990s.15 Mal-4 is a yellowish oil that is highly active and readily permeates cell membranes and viral coat layers. Likewise, the dimethoxy and trimethoxy derivatives are oily and active. These activities were also observed with O-methylated cyclolignans isolated from the same plant extract. Unlike NDGA, all these compounds were effective at inhibiting HIV replication in cell cultures (laboratory strains as well as primary isolates from AIDS patients).21 The cyclolignans 3′-demethoxyisoguaiacin and norisoguaiacin (Fig. 2B), also isolated from creosote bush, were significantly more active than all NDGA derivatives including Mal-4.15 However, these compounds occur in much smaller amounts in the extract compared to NDGA and its analogs. Full synthetic methylation of NDGA yielded the tetramethylated derivative terameprocol (M4N; Fig. 3B), which has advanced to clinical trials as an anticancer agent.22 M4N is an amorphous powder that naturally occurs in the plant, but in much lower concentration than NDGA and many NDGA derivatives.

Bottom Line: Some of these activities, namely antiherpes, antioxidant, antifungal, and anti-inflammatory, were known a century ago.Molecular mechanisms underlying the antiviral and anticancer activities have been elucidated and involve the inhibition of SP1 dependent gene transcription.We introduce the concept of a cocktail of safe well-characterized natural products from the creosote bush that would represent a bridge between oriental herbal medicines and Western drug-based therapies.

View Article: PubMed Central - PubMed

Affiliation: Mal-4 Research Institute, Baltimore, MD, USA.

ABSTRACT
The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (Larrea tridentata), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern North America and the Amerindians from South America. The plant is rich in simple bisphenyl lignans and tricyclic lignans known as cyclolignans. These compounds are responsible for many of the pharmacological activities of extracts of the plants. Some of these activities, namely antiherpes, antioxidant, antifungal, and anti-inflammatory, were known a century ago. Only recently have further studies revealed other crucial activities of the same plant molecules as powerful agents against human immunodeficiency virus, human papillomavirus, cancer, neurodegenerative diseases, and symptoms of aging. Molecular mechanisms underlying the antiviral and anticancer activities have been elucidated and involve the inhibition of SP1 dependent gene transcription. This review summarizes the recent findings on creosote bush lignans. We introduce the concept of a cocktail of safe well-characterized natural products from the creosote bush that would represent a bridge between oriental herbal medicines and Western drug-based therapies.

No MeSH data available.


Related in: MedlinePlus