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Complete Surgical Resection of a Leiomyosarcoma Arising from the Inferior Vena Cava.

Sonoda H, Minamimura K, Endo Y, Irie S, Hirata T, Kobayashi T, Mafune K, Mori M - Case Rep Med (2015)

Bottom Line: The tumor was completely resected, accompanied by removal of the posterosuperior segment of the right hepatic lobe, right adrenal gland, and a portion of the inferior vena cava (IVC).The histopathologic diagnosis was leiomyosarcoma arising from the IVC.We present a rare case of a successfully managed leiomyosarcoma of the IVC.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastrointestinal Surgery, Mitsui Memorial Hospital, Kanda-Izumi-cho 1, Chiyoda-ku, Tokyo 101-8643, Japan.

ABSTRACT
A 76-year-old Japanese man was referred to our hospital with chief complaint of right hypochondoralgia. Abdominal ultrasound showed a retroperitoneal tumor in the suprarenal region of the right kidney. Computed tomography revealed an enhanced lobular tumor with irregular, circumscribed, and indistinct border. Ultrasound-guided biopsy was performed. The tumor consisted of spindle-shaped cells with a giant nucleus and multinuclear cells. The diagnosis was leiomyosarcoma by immunohistochemical staining. The patient underwent surgery accessed by a right eighth intercostal thoracoabdominal incision. The tumor was completely resected, accompanied by removal of the posterosuperior segment of the right hepatic lobe, right adrenal gland, and a portion of the inferior vena cava (IVC). The histopathologic diagnosis was leiomyosarcoma arising from the IVC. We present a rare case of a successfully managed leiomyosarcoma of the IVC. This case suggests the importance of curative surgical resection of the tumor due to low efficacy of adjuvant chemotherapy for leiomyosarcoma.

No MeSH data available.


Related in: MedlinePlus

In the histopathologic diagnosis, Elastica van Gieson staining showed that the tumor arose from the vascular smooth muscle cells (white arrows).
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fig6: In the histopathologic diagnosis, Elastica van Gieson staining showed that the tumor arose from the vascular smooth muscle cells (white arrows).

Mentions: The tumor was white, lobular, and solid (Figure 4(b)). The size of the tumor was 50 × 45 × 40 mm. The resection margins were tumor-free, so R0 resection was performed. The tumor consisted of eosinophilic spindle-shaped cells and had coagulative necrosis and hyaline degeneration. The 3 mitoses were counted per 10 HPF, and the tumor was grade 2 in the FNCLCC grading system [3]. In immunohistostaining, the tumor showed the same pattern as the biopsy material (Figure 5). Based on the immunohistochemical findings, together with the imaging studies, the final diagnosis was primary vascular leiomyosarcoma arising from the IVC (Figure 6). The postoperative course was uneventful, and the patient was free from recurrence 5 years after the surgery.


Complete Surgical Resection of a Leiomyosarcoma Arising from the Inferior Vena Cava.

Sonoda H, Minamimura K, Endo Y, Irie S, Hirata T, Kobayashi T, Mafune K, Mori M - Case Rep Med (2015)

In the histopathologic diagnosis, Elastica van Gieson staining showed that the tumor arose from the vascular smooth muscle cells (white arrows).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488522&req=5

fig6: In the histopathologic diagnosis, Elastica van Gieson staining showed that the tumor arose from the vascular smooth muscle cells (white arrows).
Mentions: The tumor was white, lobular, and solid (Figure 4(b)). The size of the tumor was 50 × 45 × 40 mm. The resection margins were tumor-free, so R0 resection was performed. The tumor consisted of eosinophilic spindle-shaped cells and had coagulative necrosis and hyaline degeneration. The 3 mitoses were counted per 10 HPF, and the tumor was grade 2 in the FNCLCC grading system [3]. In immunohistostaining, the tumor showed the same pattern as the biopsy material (Figure 5). Based on the immunohistochemical findings, together with the imaging studies, the final diagnosis was primary vascular leiomyosarcoma arising from the IVC (Figure 6). The postoperative course was uneventful, and the patient was free from recurrence 5 years after the surgery.

Bottom Line: The tumor was completely resected, accompanied by removal of the posterosuperior segment of the right hepatic lobe, right adrenal gland, and a portion of the inferior vena cava (IVC).The histopathologic diagnosis was leiomyosarcoma arising from the IVC.We present a rare case of a successfully managed leiomyosarcoma of the IVC.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastrointestinal Surgery, Mitsui Memorial Hospital, Kanda-Izumi-cho 1, Chiyoda-ku, Tokyo 101-8643, Japan.

ABSTRACT
A 76-year-old Japanese man was referred to our hospital with chief complaint of right hypochondoralgia. Abdominal ultrasound showed a retroperitoneal tumor in the suprarenal region of the right kidney. Computed tomography revealed an enhanced lobular tumor with irregular, circumscribed, and indistinct border. Ultrasound-guided biopsy was performed. The tumor consisted of spindle-shaped cells with a giant nucleus and multinuclear cells. The diagnosis was leiomyosarcoma by immunohistochemical staining. The patient underwent surgery accessed by a right eighth intercostal thoracoabdominal incision. The tumor was completely resected, accompanied by removal of the posterosuperior segment of the right hepatic lobe, right adrenal gland, and a portion of the inferior vena cava (IVC). The histopathologic diagnosis was leiomyosarcoma arising from the IVC. We present a rare case of a successfully managed leiomyosarcoma of the IVC. This case suggests the importance of curative surgical resection of the tumor due to low efficacy of adjuvant chemotherapy for leiomyosarcoma.

No MeSH data available.


Related in: MedlinePlus