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Effect of the Y chromosome on testis weight in mice.

Satou K, Suto J - J. Vet. Med. Sci. (2015)

Bottom Line: We obtained the following results: (1) Mice with the Mus musculus domesticus-type Y chromosome had significantly heavier testis than those with the M. m. musculus-type Y chromosome. (2) Variations in Usp9y and the number of CAG repeats in Sry were significantly associated with testes weight.The A(y) allele was correlated with a reduced testis weight, and the extent of this reduction was significantly associated with a CAG repeat number polymorphism in Sry.These results suggest that Y chromosome genes not only influence testis weight but also modify the effect of the A(y) allele in mediating this phenomenon.

View Article: PubMed Central - PubMed

Affiliation: Center for Animal Disease Control and Prevention, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan.

ABSTRACT
We investigated the effect of the Y chromosome on testis weight in (B6.Cg-A(y) × Y-consomic mouse strain) F1 male mice. We obtained the following results: (1) Mice with the Mus musculus domesticus-type Y chromosome had significantly heavier testis than those with the M. m. musculus-type Y chromosome. (2) Variations in Usp9y and the number of CAG repeats in Sry were significantly associated with testes weight. The A(y) allele was correlated with a reduced testis weight, and the extent of this reduction was significantly associated with a CAG repeat number polymorphism in Sry. These results suggest that Y chromosome genes not only influence testis weight but also modify the effect of the A(y) allele in mediating this phenomenon.

No MeSH data available.


Related in: MedlinePlus

Distribution of mean Tw ratio with SE in F1-Y strains. Each strain symbol onthe y-axis represents the kind of Y-chromosome donor strain; for example, “C3H”represents F1-Y mice carrying the Y chromosome of C3H strain. Strain symbolswere sorted in descending order according to the mean Tw ratio. Statistical comparisonswere made with the Tukey-Kramer HSD tests. Values with different superscripts differsignificantly.
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fig_002: Distribution of mean Tw ratio with SE in F1-Y strains. Each strain symbol onthe y-axis represents the kind of Y-chromosome donor strain; for example, “C3H”represents F1-Y mice carrying the Y chromosome of C3H strain. Strain symbolswere sorted in descending order according to the mean Tw ratio. Statistical comparisonswere made with the Tukey-Kramer HSD tests. Values with different superscripts differsignificantly.

Mentions: When the F1-A strains were sorted in descending order with regard to their testisweight, the testis weight of the F1-Y strains was not necessarily sorted indescending order (Fig. 1). That is, the effect ofthe Ay allele in reducing testis weight differed depending on Ychromosome type. Because there was variation in the Tw ratio among Y-consomic strains based onthe Tukey–Kramer HSD test (Fig. 2Fig. 2.


Effect of the Y chromosome on testis weight in mice.

Satou K, Suto J - J. Vet. Med. Sci. (2015)

Distribution of mean Tw ratio with SE in F1-Y strains. Each strain symbol onthe y-axis represents the kind of Y-chromosome donor strain; for example, “C3H”represents F1-Y mice carrying the Y chromosome of C3H strain. Strain symbolswere sorted in descending order according to the mean Tw ratio. Statistical comparisonswere made with the Tukey-Kramer HSD tests. Values with different superscripts differsignificantly.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488418&req=5

fig_002: Distribution of mean Tw ratio with SE in F1-Y strains. Each strain symbol onthe y-axis represents the kind of Y-chromosome donor strain; for example, “C3H”represents F1-Y mice carrying the Y chromosome of C3H strain. Strain symbolswere sorted in descending order according to the mean Tw ratio. Statistical comparisonswere made with the Tukey-Kramer HSD tests. Values with different superscripts differsignificantly.
Mentions: When the F1-A strains were sorted in descending order with regard to their testisweight, the testis weight of the F1-Y strains was not necessarily sorted indescending order (Fig. 1). That is, the effect ofthe Ay allele in reducing testis weight differed depending on Ychromosome type. Because there was variation in the Tw ratio among Y-consomic strains based onthe Tukey–Kramer HSD test (Fig. 2Fig. 2.

Bottom Line: We obtained the following results: (1) Mice with the Mus musculus domesticus-type Y chromosome had significantly heavier testis than those with the M. m. musculus-type Y chromosome. (2) Variations in Usp9y and the number of CAG repeats in Sry were significantly associated with testes weight.The A(y) allele was correlated with a reduced testis weight, and the extent of this reduction was significantly associated with a CAG repeat number polymorphism in Sry.These results suggest that Y chromosome genes not only influence testis weight but also modify the effect of the A(y) allele in mediating this phenomenon.

View Article: PubMed Central - PubMed

Affiliation: Center for Animal Disease Control and Prevention, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan.

ABSTRACT
We investigated the effect of the Y chromosome on testis weight in (B6.Cg-A(y) × Y-consomic mouse strain) F1 male mice. We obtained the following results: (1) Mice with the Mus musculus domesticus-type Y chromosome had significantly heavier testis than those with the M. m. musculus-type Y chromosome. (2) Variations in Usp9y and the number of CAG repeats in Sry were significantly associated with testes weight. The A(y) allele was correlated with a reduced testis weight, and the extent of this reduction was significantly associated with a CAG repeat number polymorphism in Sry. These results suggest that Y chromosome genes not only influence testis weight but also modify the effect of the A(y) allele in mediating this phenomenon.

No MeSH data available.


Related in: MedlinePlus