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Lymphangiosarcoma with bone formation of the auricle in a dog.

Mineshige T, Sugahara G, Ohmuro T, Kamiie J, Shirota K - J. Vet. Med. Sci. (2015)

Bottom Line: Immunohistochemically, neoplastic cells were positive for vimentin and negative for cytokeratin and factor VIII-related antigen.Basement membrane around the neoplastic lumens was positive for laminin in a linear or granular pattern.Histopathological features of this case were consistent with lymphangiosarcoma, and stromal ossification was characteristic.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.

ABSTRACT
A 12-year-old mixed-breed neutered female dog was referred with cutaneous tumors at the left auricle. Histologically, the cutaneous tumor located in the dermis comprised numerous clefts and cavernous channels lined by neoplastic endothelial cells with no erythrocytes. Bone tissue without direct contact with neoplastic cells was seen in the well-developed stromal connective tissue. The neoplastic endothelial cells exhibited mild to moderate atypia. Immunohistochemically, neoplastic cells were positive for vimentin and negative for cytokeratin and factor VIII-related antigen. Basement membrane around the neoplastic lumens was positive for laminin in a linear or granular pattern. Ultrastructural examination revealed discontinuous basement membrane beneath the tumor cells. Histopathological features of this case were consistent with lymphangiosarcoma, and stromal ossification was characteristic.

No MeSH data available.


Related in: MedlinePlus

Ultrastructural examination revealed empty clefts (asterisk) devoid of blood cells,lined by neoplastic cells with oval nuclei and a paranuclear zone rich in intermediatefilaments (white arrows). Basement membrane beneath the neoplastic cells was detected(black arrows), but it was partly unclear (arrowheads). Weibel-palade bodies were notpresent in the neoplastic cells. Bar=2 µm.
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fig_006: Ultrastructural examination revealed empty clefts (asterisk) devoid of blood cells,lined by neoplastic cells with oval nuclei and a paranuclear zone rich in intermediatefilaments (white arrows). Basement membrane beneath the neoplastic cells was detected(black arrows), but it was partly unclear (arrowheads). Weibel-palade bodies were notpresent in the neoplastic cells. Bar=2 µm.

Mentions: Ultrastructural examination revealed empty clefts devoid of blood cells and lined byneoplastic cells with oval nuclei and a paranuclear zone rich in intermediate filaments. Therewere no pericytes around the neoplastic vasculatures. Weibel-palade bodies were not found inthe neoplastic cells examined. Basement membrane was apparent, but partly unclear beneath thetumor cells, of which findings might be consistent with those in immunofluorescence forlaminin (Fig. 6Fig. 6.


Lymphangiosarcoma with bone formation of the auricle in a dog.

Mineshige T, Sugahara G, Ohmuro T, Kamiie J, Shirota K - J. Vet. Med. Sci. (2015)

Ultrastructural examination revealed empty clefts (asterisk) devoid of blood cells,lined by neoplastic cells with oval nuclei and a paranuclear zone rich in intermediatefilaments (white arrows). Basement membrane beneath the neoplastic cells was detected(black arrows), but it was partly unclear (arrowheads). Weibel-palade bodies were notpresent in the neoplastic cells. Bar=2 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488415&req=5

fig_006: Ultrastructural examination revealed empty clefts (asterisk) devoid of blood cells,lined by neoplastic cells with oval nuclei and a paranuclear zone rich in intermediatefilaments (white arrows). Basement membrane beneath the neoplastic cells was detected(black arrows), but it was partly unclear (arrowheads). Weibel-palade bodies were notpresent in the neoplastic cells. Bar=2 µm.
Mentions: Ultrastructural examination revealed empty clefts devoid of blood cells and lined byneoplastic cells with oval nuclei and a paranuclear zone rich in intermediate filaments. Therewere no pericytes around the neoplastic vasculatures. Weibel-palade bodies were not found inthe neoplastic cells examined. Basement membrane was apparent, but partly unclear beneath thetumor cells, of which findings might be consistent with those in immunofluorescence forlaminin (Fig. 6Fig. 6.

Bottom Line: Immunohistochemically, neoplastic cells were positive for vimentin and negative for cytokeratin and factor VIII-related antigen.Basement membrane around the neoplastic lumens was positive for laminin in a linear or granular pattern.Histopathological features of this case were consistent with lymphangiosarcoma, and stromal ossification was characteristic.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.

ABSTRACT
A 12-year-old mixed-breed neutered female dog was referred with cutaneous tumors at the left auricle. Histologically, the cutaneous tumor located in the dermis comprised numerous clefts and cavernous channels lined by neoplastic endothelial cells with no erythrocytes. Bone tissue without direct contact with neoplastic cells was seen in the well-developed stromal connective tissue. The neoplastic endothelial cells exhibited mild to moderate atypia. Immunohistochemically, neoplastic cells were positive for vimentin and negative for cytokeratin and factor VIII-related antigen. Basement membrane around the neoplastic lumens was positive for laminin in a linear or granular pattern. Ultrastructural examination revealed discontinuous basement membrane beneath the tumor cells. Histopathological features of this case were consistent with lymphangiosarcoma, and stromal ossification was characteristic.

No MeSH data available.


Related in: MedlinePlus