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Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia.

Kanemoto H, Morikawa R, Chambers JK, Kasahara K, Hanafusa Y, Uchida K, Ohno K, Nakayama H - J. Vet. Med. Sci. (2015)

Bottom Line: Histopathological examination revealed severe diffuse interstitial pneumonia with Pneumocystis carinii infection.Severe lymphoid depletion was observed in the spleen and other organs with lymphoid follicles consisted mainly of CD3-positive T cells and few cells of B-cell lineage.B-cell hypoplasia with subsequent antibody deficiency was suspected.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.

ABSTRACT
A Pomeranian dog, 1 year- and 8 month-old neutered female, was presented with persistent respiratory distress and recurrent generalized demodicosis. Physical examination revealed cyanosis, rough respiratory sounds, multifocal alopecia and dermal erosions on the dorsal side of the forelimbs, perineal area and skin around the eyes. A severe diffuse interstitial lung pattern was observed on thoracic radiographs. The blood examination revealed neutrophilia and hypoglobulinemia. Serum immunoglobulin concentrations of IgG and IgA were low. Histopathological examination revealed severe diffuse interstitial pneumonia with Pneumocystis carinii infection. Severe lymphoid depletion was observed in the spleen and other organs with lymphoid follicles consisted mainly of CD3-positive T cells and few cells of B-cell lineage. B-cell hypoplasia with subsequent antibody deficiency was suspected.

No MeSH data available.


Related in: MedlinePlus

Hematoxylin and eosin (A), periodic-acid Schiff (B), Grocott (C), anti-CD3 (D),anti-CD20 (E) and anti-Iba-1 (F) immunostaining of the lung. Bar=100 mm. On Hematoxylinand eosin staining, foamy macrophages and small yeast-like organisms filled alveoli andbronchial space with interstitial infiltration of lymphocytes and mild fibrosis. Theorganisms were positive for periodic-acid Schiff (B) and Grocott (C) stains. Almost allof the infiltrated lymphocytes were positive for anti-CD3 immunostaining (D), and CD20positive cell was hardly detected (E). Iba-1 positive macrophages were abundant (F).
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fig_001: Hematoxylin and eosin (A), periodic-acid Schiff (B), Grocott (C), anti-CD3 (D),anti-CD20 (E) and anti-Iba-1 (F) immunostaining of the lung. Bar=100 mm. On Hematoxylinand eosin staining, foamy macrophages and small yeast-like organisms filled alveoli andbronchial space with interstitial infiltration of lymphocytes and mild fibrosis. Theorganisms were positive for periodic-acid Schiff (B) and Grocott (C) stains. Almost allof the infiltrated lymphocytes were positive for anti-CD3 immunostaining (D), and CD20positive cell was hardly detected (E). Iba-1 positive macrophages were abundant (F).

Mentions: At necropsy, the lungs were consolidated and weighed 96 g (patient’s body weight, 2.4 kg)with diffuse congestion in all lobes. The superficial lymph nodes (superficial cervical,axillary and inguinal lymph nodes) were atrophic and difficult to detect. Histopathologicalexamination revealed interstitial pneumonia characterized by moderate infiltration oflymphocytes, diffuse mild fibrosis and congestion in the alveolar wall. Foamy macrophages andsmall yeast-like organisms filled the alveolar and bronchial spaces. The organisms werepositive for periodic acid-Schiff (PAS) and Grocott’s methanamine silver (GMS) stains (Fig. 1A–1CFig. 1.


Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia.

Kanemoto H, Morikawa R, Chambers JK, Kasahara K, Hanafusa Y, Uchida K, Ohno K, Nakayama H - J. Vet. Med. Sci. (2015)

Hematoxylin and eosin (A), periodic-acid Schiff (B), Grocott (C), anti-CD3 (D),anti-CD20 (E) and anti-Iba-1 (F) immunostaining of the lung. Bar=100 mm. On Hematoxylinand eosin staining, foamy macrophages and small yeast-like organisms filled alveoli andbronchial space with interstitial infiltration of lymphocytes and mild fibrosis. Theorganisms were positive for periodic-acid Schiff (B) and Grocott (C) stains. Almost allof the infiltrated lymphocytes were positive for anti-CD3 immunostaining (D), and CD20positive cell was hardly detected (E). Iba-1 positive macrophages were abundant (F).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488410&req=5

fig_001: Hematoxylin and eosin (A), periodic-acid Schiff (B), Grocott (C), anti-CD3 (D),anti-CD20 (E) and anti-Iba-1 (F) immunostaining of the lung. Bar=100 mm. On Hematoxylinand eosin staining, foamy macrophages and small yeast-like organisms filled alveoli andbronchial space with interstitial infiltration of lymphocytes and mild fibrosis. Theorganisms were positive for periodic-acid Schiff (B) and Grocott (C) stains. Almost allof the infiltrated lymphocytes were positive for anti-CD3 immunostaining (D), and CD20positive cell was hardly detected (E). Iba-1 positive macrophages were abundant (F).
Mentions: At necropsy, the lungs were consolidated and weighed 96 g (patient’s body weight, 2.4 kg)with diffuse congestion in all lobes. The superficial lymph nodes (superficial cervical,axillary and inguinal lymph nodes) were atrophic and difficult to detect. Histopathologicalexamination revealed interstitial pneumonia characterized by moderate infiltration oflymphocytes, diffuse mild fibrosis and congestion in the alveolar wall. Foamy macrophages andsmall yeast-like organisms filled the alveolar and bronchial spaces. The organisms werepositive for periodic acid-Schiff (PAS) and Grocott’s methanamine silver (GMS) stains (Fig. 1A–1CFig. 1.

Bottom Line: Histopathological examination revealed severe diffuse interstitial pneumonia with Pneumocystis carinii infection.Severe lymphoid depletion was observed in the spleen and other organs with lymphoid follicles consisted mainly of CD3-positive T cells and few cells of B-cell lineage.B-cell hypoplasia with subsequent antibody deficiency was suspected.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.

ABSTRACT
A Pomeranian dog, 1 year- and 8 month-old neutered female, was presented with persistent respiratory distress and recurrent generalized demodicosis. Physical examination revealed cyanosis, rough respiratory sounds, multifocal alopecia and dermal erosions on the dorsal side of the forelimbs, perineal area and skin around the eyes. A severe diffuse interstitial lung pattern was observed on thoracic radiographs. The blood examination revealed neutrophilia and hypoglobulinemia. Serum immunoglobulin concentrations of IgG and IgA were low. Histopathological examination revealed severe diffuse interstitial pneumonia with Pneumocystis carinii infection. Severe lymphoid depletion was observed in the spleen and other organs with lymphoid follicles consisted mainly of CD3-positive T cells and few cells of B-cell lineage. B-cell hypoplasia with subsequent antibody deficiency was suspected.

No MeSH data available.


Related in: MedlinePlus