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Hydration Status Is Associated with Aortic Stiffness, but Not with Peripheral Arterial Stiffness, in Chronically Hemodialysed Patients.

Bia D, Galli C, Valtuille R, Zócalo Y, Wray SA, Armentano RL, Cabrera Fischer EI - Int J Nephrol (2015)

Bottom Line: Methods.Results.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Physiology Department, School of Medicine, CUiiDARTE, Republic University, 11800 Montevideo, Uruguay.

ABSTRACT
Background. Adequate fluid management could be essential to minimize high arterial stiffness observed in chronically hemodialyzed patients (CHP). Aim. To determine the association between body fluid status and central and peripheral arterial stiffness levels. Methods. Arterial stiffness was assessed in 65 CHP by measuring the pulse wave velocity (PWV) in a central arterial pathway (carotid-femoral) and in a peripheral pathway (carotid-brachial). A blood pressure-independent regional arterial stiffness index was calculated using PWV. Volume status was assessed by whole-body multiple-frequency bioimpedance. Patients were first observed as an entire group and then divided into three different fluid status-related groups: normal, overhydration, and dehydration groups. Results. Only carotid-femoral stiffness was positively associated (P < 0.05) with the hydration status evaluated through extracellular/intracellular fluid, extracellular/Total Body Fluid, and absolute and relative overhydration. Conclusion. Volume status and overload are associated with central, but not peripheral, arterial stiffness levels with independence of the blood pressure level, in CHP.

No MeSH data available.


Related in: MedlinePlus

Pulse wave velocity (PWV) and hydration status evaluated through overhydration/Extracellular fluid ratio (OH/ECF) measured in relative values using multi-impedancimetric technique. The carotid-femoral PWV-OH/ECF relationship shows a significant relationship (P < 0.05), as does the stiffness index (β)-OH/ECF relationship (P < 0.005).
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Related In: Results  -  Collection


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fig4: Pulse wave velocity (PWV) and hydration status evaluated through overhydration/Extracellular fluid ratio (OH/ECF) measured in relative values using multi-impedancimetric technique. The carotid-femoral PWV-OH/ECF relationship shows a significant relationship (P < 0.05), as does the stiffness index (β)-OH/ECF relationship (P < 0.005).

Mentions: Overhydration (OH) measured in absolute units (liters) showed a low (but significant) correlation (P < 0.05) with the right and left carotid-femoral PWV (Figure 3(a)). This positive relationship was not confirmed when β value was used, not in the right carotid-femoral pathway, or in the left one. Additionally, the right and left carotid-humeral PWV did not show correlation with OH. Finally, when OH was quantified in relative terms (%), the right and left arterial stiffness OH/ECF relationship, analyzed in the carotid-femoral and carotid-brachial pathway, showed similar results that those obtained using absolute values (see Figure 4).


Hydration Status Is Associated with Aortic Stiffness, but Not with Peripheral Arterial Stiffness, in Chronically Hemodialysed Patients.

Bia D, Galli C, Valtuille R, Zócalo Y, Wray SA, Armentano RL, Cabrera Fischer EI - Int J Nephrol (2015)

Pulse wave velocity (PWV) and hydration status evaluated through overhydration/Extracellular fluid ratio (OH/ECF) measured in relative values using multi-impedancimetric technique. The carotid-femoral PWV-OH/ECF relationship shows a significant relationship (P < 0.05), as does the stiffness index (β)-OH/ECF relationship (P < 0.005).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4488172&req=5

fig4: Pulse wave velocity (PWV) and hydration status evaluated through overhydration/Extracellular fluid ratio (OH/ECF) measured in relative values using multi-impedancimetric technique. The carotid-femoral PWV-OH/ECF relationship shows a significant relationship (P < 0.05), as does the stiffness index (β)-OH/ECF relationship (P < 0.005).
Mentions: Overhydration (OH) measured in absolute units (liters) showed a low (but significant) correlation (P < 0.05) with the right and left carotid-femoral PWV (Figure 3(a)). This positive relationship was not confirmed when β value was used, not in the right carotid-femoral pathway, or in the left one. Additionally, the right and left carotid-humeral PWV did not show correlation with OH. Finally, when OH was quantified in relative terms (%), the right and left arterial stiffness OH/ECF relationship, analyzed in the carotid-femoral and carotid-brachial pathway, showed similar results that those obtained using absolute values (see Figure 4).

Bottom Line: Methods.Results.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Physiology Department, School of Medicine, CUiiDARTE, Republic University, 11800 Montevideo, Uruguay.

ABSTRACT
Background. Adequate fluid management could be essential to minimize high arterial stiffness observed in chronically hemodialyzed patients (CHP). Aim. To determine the association between body fluid status and central and peripheral arterial stiffness levels. Methods. Arterial stiffness was assessed in 65 CHP by measuring the pulse wave velocity (PWV) in a central arterial pathway (carotid-femoral) and in a peripheral pathway (carotid-brachial). A blood pressure-independent regional arterial stiffness index was calculated using PWV. Volume status was assessed by whole-body multiple-frequency bioimpedance. Patients were first observed as an entire group and then divided into three different fluid status-related groups: normal, overhydration, and dehydration groups. Results. Only carotid-femoral stiffness was positively associated (P < 0.05) with the hydration status evaluated through extracellular/intracellular fluid, extracellular/Total Body Fluid, and absolute and relative overhydration. Conclusion. Volume status and overload are associated with central, but not peripheral, arterial stiffness levels with independence of the blood pressure level, in CHP.

No MeSH data available.


Related in: MedlinePlus