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Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender.

Maury J, Gouzi F, De Rigal P, Heraud N, Pincemail J, Molinari N, Pomiès P, Laoudj-Chenivesse D, Mercier J, Préfaut C, Hayot M - Oxid Med Cell Longev (2015)

Bottom Line: However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation.The main systemic antioxidant deficits in these patients concerned vitamins and trace elements.Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity.

View Article: PubMed Central - PubMed

Affiliation: PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France ; University of Montpellier, 34295 Montpellier, France ; Clinique du Souffle "La Solane", Fontalvie Group, 66340 Osséja, France.

ABSTRACT
Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation. This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles. We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP) levels in 54 stable COPD patients referred for a rehabilitation program. The main systemic antioxidant deficits in these patients concerned vitamins and trace elements. Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them. Interestingly, two patient profiles (clusters 3 and 4) had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx. Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity. Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.

No MeSH data available.


Related in: MedlinePlus

Relationships between systemic lipid peroxidation and (a) muscle mass index (kg/m2) and (b) 6-MWD (% pred.). (a) Systemic lipid peroxidation, expressed in μmol/L, was significantly and negatively correlated with muscle mass index (r = −0.38; p < 0.01) in 54 COPD patients. (b) Systemic lipid peroxidation, expressed in μmol/L, was significantly and negatively correlated with 6-MWD (r = 0.29; p < 0.05) in 54 COPD patients.
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fig5: Relationships between systemic lipid peroxidation and (a) muscle mass index (kg/m2) and (b) 6-MWD (% pred.). (a) Systemic lipid peroxidation, expressed in μmol/L, was significantly and negatively correlated with muscle mass index (r = −0.38; p < 0.01) in 54 COPD patients. (b) Systemic lipid peroxidation, expressed in μmol/L, was significantly and negatively correlated with 6-MWD (r = 0.29; p < 0.05) in 54 COPD patients.

Mentions: When the systemic OS markers were considered separately, univariate analysis revealed a significant and negative correlation between the copper/zinc ratio and the muscle mass index (p < 0.05; r = −0.49). Similarly, systemic lipid peroxidation was significantly and negatively correlated with the muscle mass index (p < 0.01; r = −0.38; Figure 5(a)) and the 6-MWD in % predicted (p < 0.05; r = −0.29; Figure 5(b)).


Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender.

Maury J, Gouzi F, De Rigal P, Heraud N, Pincemail J, Molinari N, Pomiès P, Laoudj-Chenivesse D, Mercier J, Préfaut C, Hayot M - Oxid Med Cell Longev (2015)

Relationships between systemic lipid peroxidation and (a) muscle mass index (kg/m2) and (b) 6-MWD (% pred.). (a) Systemic lipid peroxidation, expressed in μmol/L, was significantly and negatively correlated with muscle mass index (r = −0.38; p < 0.01) in 54 COPD patients. (b) Systemic lipid peroxidation, expressed in μmol/L, was significantly and negatively correlated with 6-MWD (r = 0.29; p < 0.05) in 54 COPD patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4488160&req=5

fig5: Relationships between systemic lipid peroxidation and (a) muscle mass index (kg/m2) and (b) 6-MWD (% pred.). (a) Systemic lipid peroxidation, expressed in μmol/L, was significantly and negatively correlated with muscle mass index (r = −0.38; p < 0.01) in 54 COPD patients. (b) Systemic lipid peroxidation, expressed in μmol/L, was significantly and negatively correlated with 6-MWD (r = 0.29; p < 0.05) in 54 COPD patients.
Mentions: When the systemic OS markers were considered separately, univariate analysis revealed a significant and negative correlation between the copper/zinc ratio and the muscle mass index (p < 0.05; r = −0.49). Similarly, systemic lipid peroxidation was significantly and negatively correlated with the muscle mass index (p < 0.01; r = −0.38; Figure 5(a)) and the 6-MWD in % predicted (p < 0.05; r = −0.29; Figure 5(b)).

Bottom Line: However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation.The main systemic antioxidant deficits in these patients concerned vitamins and trace elements.Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity.

View Article: PubMed Central - PubMed

Affiliation: PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France ; University of Montpellier, 34295 Montpellier, France ; Clinique du Souffle "La Solane", Fontalvie Group, 66340 Osséja, France.

ABSTRACT
Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation. This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles. We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP) levels in 54 stable COPD patients referred for a rehabilitation program. The main systemic antioxidant deficits in these patients concerned vitamins and trace elements. Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them. Interestingly, two patient profiles (clusters 3 and 4) had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx. Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity. Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.

No MeSH data available.


Related in: MedlinePlus