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Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender.

Maury J, Gouzi F, De Rigal P, Heraud N, Pincemail J, Molinari N, Pomiès P, Laoudj-Chenivesse D, Mercier J, Préfaut C, Hayot M - Oxid Med Cell Longev (2015)

Bottom Line: However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation.The main systemic antioxidant deficits in these patients concerned vitamins and trace elements.Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity.

View Article: PubMed Central - PubMed

Affiliation: PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France ; University of Montpellier, 34295 Montpellier, France ; Clinique du Souffle "La Solane", Fontalvie Group, 66340 Osséja, France.

ABSTRACT
Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation. This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles. We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP) levels in 54 stable COPD patients referred for a rehabilitation program. The main systemic antioxidant deficits in these patients concerned vitamins and trace elements. Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them. Interestingly, two patient profiles (clusters 3 and 4) had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx. Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity. Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.

No MeSH data available.


Related in: MedlinePlus

Quality of micronutrient intake in 40 COPD patients. For each micronutrient, results showed the proportion of patients with COPD with dietary intake above (grey part) or below (dark part) recommendations. Recommended daily intake (RDI) was defined in function of gender.
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fig3: Quality of micronutrient intake in 40 COPD patients. For each micronutrient, results showed the proportion of patients with COPD with dietary intake above (grey part) or below (dark part) recommendations. Recommended daily intake (RDI) was defined in function of gender.

Mentions: Our data also revealed a substantial imbalance in dietary intake, in particular with regard to micronutrients, although we observed no significant correlation with systemic antioxidant levels. Intake of vitamin C and E was below the RDI in 70% and 92% of COPD patients, respectively (Figure 3). Regarding trace element consumption, absolute intake was below the RDI for zinc and copper in 68% and 27% of COPD patients, respectively, while selenium intake was normal (Figure 3).


Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender.

Maury J, Gouzi F, De Rigal P, Heraud N, Pincemail J, Molinari N, Pomiès P, Laoudj-Chenivesse D, Mercier J, Préfaut C, Hayot M - Oxid Med Cell Longev (2015)

Quality of micronutrient intake in 40 COPD patients. For each micronutrient, results showed the proportion of patients with COPD with dietary intake above (grey part) or below (dark part) recommendations. Recommended daily intake (RDI) was defined in function of gender.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4488160&req=5

fig3: Quality of micronutrient intake in 40 COPD patients. For each micronutrient, results showed the proportion of patients with COPD with dietary intake above (grey part) or below (dark part) recommendations. Recommended daily intake (RDI) was defined in function of gender.
Mentions: Our data also revealed a substantial imbalance in dietary intake, in particular with regard to micronutrients, although we observed no significant correlation with systemic antioxidant levels. Intake of vitamin C and E was below the RDI in 70% and 92% of COPD patients, respectively (Figure 3). Regarding trace element consumption, absolute intake was below the RDI for zinc and copper in 68% and 27% of COPD patients, respectively, while selenium intake was normal (Figure 3).

Bottom Line: However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation.The main systemic antioxidant deficits in these patients concerned vitamins and trace elements.Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity.

View Article: PubMed Central - PubMed

Affiliation: PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France ; University of Montpellier, 34295 Montpellier, France ; Clinique du Souffle "La Solane", Fontalvie Group, 66340 Osséja, France.

ABSTRACT
Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation. This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles. We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP) levels in 54 stable COPD patients referred for a rehabilitation program. The main systemic antioxidant deficits in these patients concerned vitamins and trace elements. Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them. Interestingly, two patient profiles (clusters 3 and 4) had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx. Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity. Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.

No MeSH data available.


Related in: MedlinePlus