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Efficacy of Acupuncture in Children with Nocturnal Enuresis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Lv ZT, Song W, Wu J, Yang J, Wang T, Wu CH, Gao F, Yuan XC, Liu JH, Li M - Evid Based Complement Alternat Med (2015)

Bottom Line: The results of meta-analysis showed that acupuncture therapy was more effective for clinical efficacy when compared with placebo or pharmacological treatment.Conclusion.Rigorous high quality RCTs are urgently needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

ABSTRACT
Background. Nocturnal enuresis (NE) is recognized as a widespread health problem in young children and adolescents. Clinical researches about acupuncture therapy for nocturnal enuresis are increasing, while systematic reviews assessing the efficacy of acupuncture therapy are still lacking. Objective. This study aims to assess the effectiveness of acupuncture therapy for nocturnal enuresis. Materials and Methods. A comprehensive literature search of 8 databases was performed up to June 2014; randomized controlled trials which compared acupuncture therapy and placebo treatment or pharmacological therapy were identified. A meta-analysis was conducted. Results. This review included 21 RCTs and a total of 1590 subjects. The overall methodological qualities were low. The results of meta-analysis showed that acupuncture therapy was more effective for clinical efficacy when compared with placebo or pharmacological treatment. Adverse events associated with acupuncture therapy were not documented. Conclusion. Based on the findings of this study, we cautiously suggest that acupuncture therapy could improve the clinical efficacy. However, the beneficial effect of acupuncture might be overstated due to low methodological qualities. Rigorous high quality RCTs are urgently needed.

No MeSH data available.


Related in: MedlinePlus

Funnel plot of randomized controlled trials.
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Related In: Results  -  Collection


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fig5: Funnel plot of randomized controlled trials.

Mentions: We conducted a funnel plot analysis of the aforementioned 19 studies [6–9, 11–16, 18–26]. P value associated with Begg's test was 0.009 and P value associated with Egger's test was 0.002. The resulting graph was asymmetrical, suggesting the possibility of publication bias, which was in line with results of Begg's test and Egger's test (Figure 5). In addition, language bias may exist because most of included studies were published in Chinese.


Efficacy of Acupuncture in Children with Nocturnal Enuresis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Lv ZT, Song W, Wu J, Yang J, Wang T, Wu CH, Gao F, Yuan XC, Liu JH, Li M - Evid Based Complement Alternat Med (2015)

Funnel plot of randomized controlled trials.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4488007&req=5

fig5: Funnel plot of randomized controlled trials.
Mentions: We conducted a funnel plot analysis of the aforementioned 19 studies [6–9, 11–16, 18–26]. P value associated with Begg's test was 0.009 and P value associated with Egger's test was 0.002. The resulting graph was asymmetrical, suggesting the possibility of publication bias, which was in line with results of Begg's test and Egger's test (Figure 5). In addition, language bias may exist because most of included studies were published in Chinese.

Bottom Line: The results of meta-analysis showed that acupuncture therapy was more effective for clinical efficacy when compared with placebo or pharmacological treatment.Conclusion.Rigorous high quality RCTs are urgently needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

ABSTRACT
Background. Nocturnal enuresis (NE) is recognized as a widespread health problem in young children and adolescents. Clinical researches about acupuncture therapy for nocturnal enuresis are increasing, while systematic reviews assessing the efficacy of acupuncture therapy are still lacking. Objective. This study aims to assess the effectiveness of acupuncture therapy for nocturnal enuresis. Materials and Methods. A comprehensive literature search of 8 databases was performed up to June 2014; randomized controlled trials which compared acupuncture therapy and placebo treatment or pharmacological therapy were identified. A meta-analysis was conducted. Results. This review included 21 RCTs and a total of 1590 subjects. The overall methodological qualities were low. The results of meta-analysis showed that acupuncture therapy was more effective for clinical efficacy when compared with placebo or pharmacological treatment. Adverse events associated with acupuncture therapy were not documented. Conclusion. Based on the findings of this study, we cautiously suggest that acupuncture therapy could improve the clinical efficacy. However, the beneficial effect of acupuncture might be overstated due to low methodological qualities. Rigorous high quality RCTs are urgently needed.

No MeSH data available.


Related in: MedlinePlus