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Efficacy of Acupuncture in Children with Nocturnal Enuresis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Lv ZT, Song W, Wu J, Yang J, Wang T, Wu CH, Gao F, Yuan XC, Liu JH, Li M - Evid Based Complement Alternat Med (2015)

Bottom Line: The results of meta-analysis showed that acupuncture therapy was more effective for clinical efficacy when compared with placebo or pharmacological treatment.Conclusion.Rigorous high quality RCTs are urgently needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

ABSTRACT
Background. Nocturnal enuresis (NE) is recognized as a widespread health problem in young children and adolescents. Clinical researches about acupuncture therapy for nocturnal enuresis are increasing, while systematic reviews assessing the efficacy of acupuncture therapy are still lacking. Objective. This study aims to assess the effectiveness of acupuncture therapy for nocturnal enuresis. Materials and Methods. A comprehensive literature search of 8 databases was performed up to June 2014; randomized controlled trials which compared acupuncture therapy and placebo treatment or pharmacological therapy were identified. A meta-analysis was conducted. Results. This review included 21 RCTs and a total of 1590 subjects. The overall methodological qualities were low. The results of meta-analysis showed that acupuncture therapy was more effective for clinical efficacy when compared with placebo or pharmacological treatment. Adverse events associated with acupuncture therapy were not documented. Conclusion. Based on the findings of this study, we cautiously suggest that acupuncture therapy could improve the clinical efficacy. However, the beneficial effect of acupuncture might be overstated due to low methodological qualities. Rigorous high quality RCTs are urgently needed.

No MeSH data available.


Related in: MedlinePlus

Subgroup analysis: acupuncture therapy versus desmopressin.
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Related In: Results  -  Collection


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fig4: Subgroup analysis: acupuncture therapy versus desmopressin.

Mentions: A subgroup analysis was conducted to further evaluate the clinical effect of acupuncture therapy and identify the heterogeneity within western medicine group. The western medicine group was divided into four groups according to the medication types. Four studies used Meclofenoxate as control intervention [6, 9, 11, 22], three studies used desmopressin as medicine control [13, 16, 23], and the remaining two studies [8, 25] treated nocturnal children with imipramine hydrochloride and oxybutynin, respectively. The pooled data showed significant difference between acupuncture therapy and Meclofenoxate (OR = 2.81; 95% CI, 1.62–3.96; P < 0.0001), with no obvious heterogeneity (Figure 3). The pooled effects of three independent trials suggested that there was no significant difference between desmopressin and acupuncture in treating NE (OR = 1.57; 95% CI, 0.38–6.57; P = 0.54) (Figure 4). Since only one trial utilized imipramine hydrochloride as medicine control and only one trial utilized oxybutynin, results from these two studies are presented as narrative description. There was no significant difference between imipramine hydrochloride and acupuncture therapy (OR = 1.71; 95% CI, 0.65–4.51; P = 0.27). Compared with oxybutynin, acupuncture could not further improve the clinical effect (OR = 3.57; 95% CI, 0.53–2; P = 0.54).


Efficacy of Acupuncture in Children with Nocturnal Enuresis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Lv ZT, Song W, Wu J, Yang J, Wang T, Wu CH, Gao F, Yuan XC, Liu JH, Li M - Evid Based Complement Alternat Med (2015)

Subgroup analysis: acupuncture therapy versus desmopressin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4488007&req=5

fig4: Subgroup analysis: acupuncture therapy versus desmopressin.
Mentions: A subgroup analysis was conducted to further evaluate the clinical effect of acupuncture therapy and identify the heterogeneity within western medicine group. The western medicine group was divided into four groups according to the medication types. Four studies used Meclofenoxate as control intervention [6, 9, 11, 22], three studies used desmopressin as medicine control [13, 16, 23], and the remaining two studies [8, 25] treated nocturnal children with imipramine hydrochloride and oxybutynin, respectively. The pooled data showed significant difference between acupuncture therapy and Meclofenoxate (OR = 2.81; 95% CI, 1.62–3.96; P < 0.0001), with no obvious heterogeneity (Figure 3). The pooled effects of three independent trials suggested that there was no significant difference between desmopressin and acupuncture in treating NE (OR = 1.57; 95% CI, 0.38–6.57; P = 0.54) (Figure 4). Since only one trial utilized imipramine hydrochloride as medicine control and only one trial utilized oxybutynin, results from these two studies are presented as narrative description. There was no significant difference between imipramine hydrochloride and acupuncture therapy (OR = 1.71; 95% CI, 0.65–4.51; P = 0.27). Compared with oxybutynin, acupuncture could not further improve the clinical effect (OR = 3.57; 95% CI, 0.53–2; P = 0.54).

Bottom Line: The results of meta-analysis showed that acupuncture therapy was more effective for clinical efficacy when compared with placebo or pharmacological treatment.Conclusion.Rigorous high quality RCTs are urgently needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

ABSTRACT
Background. Nocturnal enuresis (NE) is recognized as a widespread health problem in young children and adolescents. Clinical researches about acupuncture therapy for nocturnal enuresis are increasing, while systematic reviews assessing the efficacy of acupuncture therapy are still lacking. Objective. This study aims to assess the effectiveness of acupuncture therapy for nocturnal enuresis. Materials and Methods. A comprehensive literature search of 8 databases was performed up to June 2014; randomized controlled trials which compared acupuncture therapy and placebo treatment or pharmacological therapy were identified. A meta-analysis was conducted. Results. This review included 21 RCTs and a total of 1590 subjects. The overall methodological qualities were low. The results of meta-analysis showed that acupuncture therapy was more effective for clinical efficacy when compared with placebo or pharmacological treatment. Adverse events associated with acupuncture therapy were not documented. Conclusion. Based on the findings of this study, we cautiously suggest that acupuncture therapy could improve the clinical efficacy. However, the beneficial effect of acupuncture might be overstated due to low methodological qualities. Rigorous high quality RCTs are urgently needed.

No MeSH data available.


Related in: MedlinePlus