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Maternal Serum Meteorin Levels and the Risk of Preeclampsia.

Garcés MF, Sanchez E, Cardona LF, Simanca EL, González I, Leal LG, Mora JA, Bedoya A, Alzate JP, Sánchez ÁY, Eslava-Schmalbach JH, Franco-Vega R, Parra MO, Ruíz-Parra AI, Diéguez C, Nogueiras R, Caminos JE - PLoS ONE (2015)

Bottom Line: In healthy pregnant women, serum METRN levels were significantly elevated in early pregnancy compared to middle and late pregnancy.METRN levels are significantly lower only in early pregnancy in preeclamptic women when compared to healthy pregnant women.Decision trees that did not include METRN levels in the first trimester had a reduced sensitivity of 56% in the detection of preeclamptic women, compared to a sensitivity of 69% when METRN was included.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.

ABSTRACT

Background: Meteorin (METRN) is a recently described neutrophic factor with angiogenic properties. This is a nested case-control study in a longitudinal cohort study that describes the serum profile of METRN during different periods of gestation in healthy and preeclamptic pregnant women. Moreover, we explore the possible application of METRN as a biomarker.

Methods and findings: Serum METRN was measured by ELISA in a longitudinal prospective cohort study in 37 healthy pregnant women, 16 mild preeclamptic women, and 20 healthy non-pregnant women during the menstrual cycle with the aim of assessing serum METRN levels and its correlations with other metabolic parameters. Immunostaining for METRN protein was performed in placenta. A multivariate logistic regression model was proposed and a classifier model was formulated for predicting preeclampsia in early and middle pregnancy. The performance in classification was evaluated using measures such as sensitivity, specificity, and the receiver operating characteristic (ROC) curve. In healthy pregnant women, serum METRN levels were significantly elevated in early pregnancy compared to middle and late pregnancy. METRN levels are significantly lower only in early pregnancy in preeclamptic women when compared to healthy pregnant women. Decision trees that did not include METRN levels in the first trimester had a reduced sensitivity of 56% in the detection of preeclamptic women, compared to a sensitivity of 69% when METRN was included.

Conclusions: The joint measurements of circulating METRN levels in the first trimester and systolic blood pressure and weight in the second trimester significantly increase the probabilities of predicting preeclampsia.

No MeSH data available.


Related in: MedlinePlus

Serum METRN levels in the three trimesters of pregnancy and in a group of eumenorrheic woman.The highest levels of METRN are observed in early pregnancy (EP) and then decline with advancing gestation in the subsequent periods, in middle pregnancy (MP), and late pregnancy (LP), with this reduction in serum METRN being statistically significant (p <0.01). Moreover, significant differences were observed when comparing serum METRN in the groups of eumenorrheic women (EW) and EP (p <0.001).
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pone.0131013.g002: Serum METRN levels in the three trimesters of pregnancy and in a group of eumenorrheic woman.The highest levels of METRN are observed in early pregnancy (EP) and then decline with advancing gestation in the subsequent periods, in middle pregnancy (MP), and late pregnancy (LP), with this reduction in serum METRN being statistically significant (p <0.01). Moreover, significant differences were observed when comparing serum METRN in the groups of eumenorrheic women (EW) and EP (p <0.001).

Mentions: Serum METRN levels were significantly higher in the first stage of gestation when compared to healthy non—pregnant women (Fig 2 and Fig C in S1 Fig). Circulating METRN levels were also significantly higher in the first trimester in comparison to the second and third trimesters of pregnancy (p <0.01) (Fig 2 and Table 1). Additionally, METRN levels in middle and late pregnancy were similar to the ones obtained in non-pregnant women (Fig 2). No statistically significant associations were observed between METRN concentrations in early pregnancy (EP) compared to middle (r = -0.043, P = 0.804) (MP) and late pregnancy (r = -0.266, P = 0.122) (LP) (Figs A and B in S1 Fig, respectively). In these figures, most of the patients are under the solid line (y = x), endorsing the conclusion that MERTN levels tend to be higher in EP than in MP or LP. Additionally, a dot plot for EP serum METRN concentration in normal pregnancy and eumenorrheic women (EW) is shown in Fig C in S1 Fig. The bar means values are also shown. As stated before, there is a significant difference between the groups (P<0.001).


Maternal Serum Meteorin Levels and the Risk of Preeclampsia.

Garcés MF, Sanchez E, Cardona LF, Simanca EL, González I, Leal LG, Mora JA, Bedoya A, Alzate JP, Sánchez ÁY, Eslava-Schmalbach JH, Franco-Vega R, Parra MO, Ruíz-Parra AI, Diéguez C, Nogueiras R, Caminos JE - PLoS ONE (2015)

Serum METRN levels in the three trimesters of pregnancy and in a group of eumenorrheic woman.The highest levels of METRN are observed in early pregnancy (EP) and then decline with advancing gestation in the subsequent periods, in middle pregnancy (MP), and late pregnancy (LP), with this reduction in serum METRN being statistically significant (p <0.01). Moreover, significant differences were observed when comparing serum METRN in the groups of eumenorrheic women (EW) and EP (p <0.001).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4487999&req=5

pone.0131013.g002: Serum METRN levels in the three trimesters of pregnancy and in a group of eumenorrheic woman.The highest levels of METRN are observed in early pregnancy (EP) and then decline with advancing gestation in the subsequent periods, in middle pregnancy (MP), and late pregnancy (LP), with this reduction in serum METRN being statistically significant (p <0.01). Moreover, significant differences were observed when comparing serum METRN in the groups of eumenorrheic women (EW) and EP (p <0.001).
Mentions: Serum METRN levels were significantly higher in the first stage of gestation when compared to healthy non—pregnant women (Fig 2 and Fig C in S1 Fig). Circulating METRN levels were also significantly higher in the first trimester in comparison to the second and third trimesters of pregnancy (p <0.01) (Fig 2 and Table 1). Additionally, METRN levels in middle and late pregnancy were similar to the ones obtained in non-pregnant women (Fig 2). No statistically significant associations were observed between METRN concentrations in early pregnancy (EP) compared to middle (r = -0.043, P = 0.804) (MP) and late pregnancy (r = -0.266, P = 0.122) (LP) (Figs A and B in S1 Fig, respectively). In these figures, most of the patients are under the solid line (y = x), endorsing the conclusion that MERTN levels tend to be higher in EP than in MP or LP. Additionally, a dot plot for EP serum METRN concentration in normal pregnancy and eumenorrheic women (EW) is shown in Fig C in S1 Fig. The bar means values are also shown. As stated before, there is a significant difference between the groups (P<0.001).

Bottom Line: In healthy pregnant women, serum METRN levels were significantly elevated in early pregnancy compared to middle and late pregnancy.METRN levels are significantly lower only in early pregnancy in preeclamptic women when compared to healthy pregnant women.Decision trees that did not include METRN levels in the first trimester had a reduced sensitivity of 56% in the detection of preeclamptic women, compared to a sensitivity of 69% when METRN was included.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.

ABSTRACT

Background: Meteorin (METRN) is a recently described neutrophic factor with angiogenic properties. This is a nested case-control study in a longitudinal cohort study that describes the serum profile of METRN during different periods of gestation in healthy and preeclamptic pregnant women. Moreover, we explore the possible application of METRN as a biomarker.

Methods and findings: Serum METRN was measured by ELISA in a longitudinal prospective cohort study in 37 healthy pregnant women, 16 mild preeclamptic women, and 20 healthy non-pregnant women during the menstrual cycle with the aim of assessing serum METRN levels and its correlations with other metabolic parameters. Immunostaining for METRN protein was performed in placenta. A multivariate logistic regression model was proposed and a classifier model was formulated for predicting preeclampsia in early and middle pregnancy. The performance in classification was evaluated using measures such as sensitivity, specificity, and the receiver operating characteristic (ROC) curve. In healthy pregnant women, serum METRN levels were significantly elevated in early pregnancy compared to middle and late pregnancy. METRN levels are significantly lower only in early pregnancy in preeclamptic women when compared to healthy pregnant women. Decision trees that did not include METRN levels in the first trimester had a reduced sensitivity of 56% in the detection of preeclamptic women, compared to a sensitivity of 69% when METRN was included.

Conclusions: The joint measurements of circulating METRN levels in the first trimester and systolic blood pressure and weight in the second trimester significantly increase the probabilities of predicting preeclampsia.

No MeSH data available.


Related in: MedlinePlus