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Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence.

Yen CH, Yeh YW, Liang CS, Ho PS, Kuo SC, Huang CC, Chen CY, Shih MC, Ma KH, Peng GS, Lu RB, Huang SY - PLoS ONE (2015)

Bottom Line: Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001).Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile.Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

ABSTRACT
Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.

No MeSH data available.


Related in: MedlinePlus

Graph showing correlation of striatal specific uptake ratio of [99mTc]TRODAT-1with harm avoidance.Significant association between harm avoidance and SUR over total caudate(ρ = 0.527, p = 0.06) and total striatum (ρ = 0.475, p = 0.014) existed in pure alcohol-dependent individuals. The coefficient of determination (r2) is 28.4% for the alcohol dependent group (n = 26) between harm avoidance and total striatum SUR.
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pone.0131017.g004: Graph showing correlation of striatal specific uptake ratio of [99mTc]TRODAT-1with harm avoidance.Significant association between harm avoidance and SUR over total caudate(ρ = 0.527, p = 0.06) and total striatum (ρ = 0.475, p = 0.014) existed in pure alcohol-dependent individuals. The coefficient of determination (r2) is 28.4% for the alcohol dependent group (n = 26) between harm avoidance and total striatum SUR.

Mentions: Patients with AD demonstrated marginal differences from controls on novelty seeking (z = -1.723, p = 0.085) and harm avoidance (z = -1.973, p = 0.049) (Table 1). A significant positive correlation between harm avoidance and DAT availability was found in the patient group (rho = 0.475, p = 0.014 for striatum; rho = 0.474, p = 0.014 for the putamen; and rho = 0.527, p = 0.006 for the caudate, Conservative p value would be 0.05/3 = 0.017 after Bonferroni correction) (Fig 4), but not in the healthy control group (p > 0.05). The novelty seeking scale did not significantly correlate with DAT availability for either group in the brain regions studied.


Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence.

Yen CH, Yeh YW, Liang CS, Ho PS, Kuo SC, Huang CC, Chen CY, Shih MC, Ma KH, Peng GS, Lu RB, Huang SY - PLoS ONE (2015)

Graph showing correlation of striatal specific uptake ratio of [99mTc]TRODAT-1with harm avoidance.Significant association between harm avoidance and SUR over total caudate(ρ = 0.527, p = 0.06) and total striatum (ρ = 0.475, p = 0.014) existed in pure alcohol-dependent individuals. The coefficient of determination (r2) is 28.4% for the alcohol dependent group (n = 26) between harm avoidance and total striatum SUR.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4487997&req=5

pone.0131017.g004: Graph showing correlation of striatal specific uptake ratio of [99mTc]TRODAT-1with harm avoidance.Significant association between harm avoidance and SUR over total caudate(ρ = 0.527, p = 0.06) and total striatum (ρ = 0.475, p = 0.014) existed in pure alcohol-dependent individuals. The coefficient of determination (r2) is 28.4% for the alcohol dependent group (n = 26) between harm avoidance and total striatum SUR.
Mentions: Patients with AD demonstrated marginal differences from controls on novelty seeking (z = -1.723, p = 0.085) and harm avoidance (z = -1.973, p = 0.049) (Table 1). A significant positive correlation between harm avoidance and DAT availability was found in the patient group (rho = 0.475, p = 0.014 for striatum; rho = 0.474, p = 0.014 for the putamen; and rho = 0.527, p = 0.006 for the caudate, Conservative p value would be 0.05/3 = 0.017 after Bonferroni correction) (Fig 4), but not in the healthy control group (p > 0.05). The novelty seeking scale did not significantly correlate with DAT availability for either group in the brain regions studied.

Bottom Line: Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001).Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile.Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

ABSTRACT
Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.

No MeSH data available.


Related in: MedlinePlus