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Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence.

Yen CH, Yeh YW, Liang CS, Ho PS, Kuo SC, Huang CC, Chen CY, Shih MC, Ma KH, Peng GS, Lu RB, Huang SY - PLoS ONE (2015)

Bottom Line: Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001).Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile.Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

ABSTRACT
Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.

No MeSH data available.


Related in: MedlinePlus

Graph showing correlation of striatal specific uptake ratio of [99mTc] TRODAT-1 with perseverative errors and total errors.Significant association between these parameters existed healthy controls.
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pone.0131017.g003: Graph showing correlation of striatal specific uptake ratio of [99mTc] TRODAT-1 with perseverative errors and total errors.Significant association between these parameters existed healthy controls.

Mentions: The association between striatal SUR and WCST parameters among healthy controls revealed that total correct (rho = -0.732, p < 0.001), total errors (rho = -0.714, p < 0.001), and perseverative errors (rho = -0.665, p < 0.001) reached statistical significance, and a marginal association was observed for non-perseverative errors (rho = -0.596, p = 0.003). Patients with AD had a marginally significant association between striatal SUR and total errors (rho = -0.445, p = 0.023), perseverative errors (rho = -0.416, p = 0.035), and categories completed (rho = -0.392, p = 0.048). However, these results did not meet the significance threshold after adjusting for multiple comparisons (Conservative P value would be 0.05/36 = 0.0014) (Table 3). Fig 3 presents the significant associations found between striatal SUR and total and perseverative errors among healthy controls.


Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence.

Yen CH, Yeh YW, Liang CS, Ho PS, Kuo SC, Huang CC, Chen CY, Shih MC, Ma KH, Peng GS, Lu RB, Huang SY - PLoS ONE (2015)

Graph showing correlation of striatal specific uptake ratio of [99mTc] TRODAT-1 with perseverative errors and total errors.Significant association between these parameters existed healthy controls.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4487997&req=5

pone.0131017.g003: Graph showing correlation of striatal specific uptake ratio of [99mTc] TRODAT-1 with perseverative errors and total errors.Significant association between these parameters existed healthy controls.
Mentions: The association between striatal SUR and WCST parameters among healthy controls revealed that total correct (rho = -0.732, p < 0.001), total errors (rho = -0.714, p < 0.001), and perseverative errors (rho = -0.665, p < 0.001) reached statistical significance, and a marginal association was observed for non-perseverative errors (rho = -0.596, p = 0.003). Patients with AD had a marginally significant association between striatal SUR and total errors (rho = -0.445, p = 0.023), perseverative errors (rho = -0.416, p = 0.035), and categories completed (rho = -0.392, p = 0.048). However, these results did not meet the significance threshold after adjusting for multiple comparisons (Conservative P value would be 0.05/36 = 0.0014) (Table 3). Fig 3 presents the significant associations found between striatal SUR and total and perseverative errors among healthy controls.

Bottom Line: Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001).Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile.Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

ABSTRACT
Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.

No MeSH data available.


Related in: MedlinePlus