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Sensory Deprivation during Early Postnatal Period Alters the Density of Interneurons in the Mouse Prefrontal Cortex.

Ueno H, Suemitsu S, Matsumoto Y, Okamoto M - Neural Plast. (2015)

Bottom Line: We determined the effects of sensory deprivation from birth to postnatal day 28 (P28) or P58 on the density of parvalbumin (PV), calbindin (CB), and calretinin (CR) neurons in the prelimbic, infralimbic, and dorsal anterior cingulate cortices.The density of PV and CB neurons was significantly increased in layer 5/6 (L5/6).These results suggest that long-term sensory deprivation causes the changes of intracortical inhibitory networks in the PFC and the changes of inhibitory networks in the PFC may contribute to cross-modal plasticity.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan ; Department of Medical Technology, Kawasaki College of Allied Health Professions, Okayama 701-0194, Japan.

ABSTRACT
Early loss of one sensory system can cause improved function of other sensory systems. However, both the time course and neuronal mechanism of cross-modal plasticity remain elusive. Recent study using functional MRI in humans suggests a role of the prefrontal cortex (PFC) in cross-modal plasticity. Since this phenomenon is assumed to be associated with altered GABAergic inhibition in the PFC, we have tested the hypothesis that early postnatal sensory deprivation causes the changes of inhibitory neuronal circuit in different regions of the PFC of the mice. We determined the effects of sensory deprivation from birth to postnatal day 28 (P28) or P58 on the density of parvalbumin (PV), calbindin (CB), and calretinin (CR) neurons in the prelimbic, infralimbic, and dorsal anterior cingulate cortices. The density of PV and CB neurons was significantly increased in layer 5/6 (L5/6). Moreover, the density of CR neurons was higher in L2/3 in sensory deprived mice compared to intact mice. These changes were more prominent at P56 than at P28. These results suggest that long-term sensory deprivation causes the changes of intracortical inhibitory networks in the PFC and the changes of inhibitory networks in the PFC may contribute to cross-modal plasticity.

No MeSH data available.


Sensory deprivation changes PV neuron density in the PFC. The density of PV neurons in the PL (a, b), IL (c, d), and dAC (e, f). PV neuron density at P28 (a, c, e) and P58 (b, d, f) in each area are shown. (a)-(b) The density of PV neurons was increased in L5/6 by sensory deprivation at P56. (c)-(d) The density of PV neurons in L2/3 was decreased at P28 by sensory deprivation, but it was increased in L5/6 at P56. (e)-(f) The density of PV neurons in L5/6 was increased with sensory deprivation at both P28 and P56. Data are expressed as mean density S.E.M. (n = 6 per group). Abbreviations are the same as in Figure 4. ∗P < 0.05 compared with intact mice.
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fig4: Sensory deprivation changes PV neuron density in the PFC. The density of PV neurons in the PL (a, b), IL (c, d), and dAC (e, f). PV neuron density at P28 (a, c, e) and P58 (b, d, f) in each area are shown. (a)-(b) The density of PV neurons was increased in L5/6 by sensory deprivation at P56. (c)-(d) The density of PV neurons in L2/3 was decreased at P28 by sensory deprivation, but it was increased in L5/6 at P56. (e)-(f) The density of PV neurons in L5/6 was increased with sensory deprivation at both P28 and P56. Data are expressed as mean density S.E.M. (n = 6 per group). Abbreviations are the same as in Figure 4. ∗P < 0.05 compared with intact mice.

Mentions: There was no change in the density of PV neurons between intact mice and sensory deprived mice in the PL (Figure 4(a)). In L2/3 of the IL, whisker trimming, dark rearing, or dark rearing of whisker trimmed mice significantly decreased PV neuron density (Figure 4(c)). Moreover, whisker trimming significantly decreased PV neuron density in L5/6 of the IL (Figure 4(c)). Whisker trimming, dark rearing, or dark rearing of whisker trimmed mice significantly increased PV neuron density in L5/6 but not in L2/3 of the dAC (Figure 4(e)).


Sensory Deprivation during Early Postnatal Period Alters the Density of Interneurons in the Mouse Prefrontal Cortex.

Ueno H, Suemitsu S, Matsumoto Y, Okamoto M - Neural Plast. (2015)

Sensory deprivation changes PV neuron density in the PFC. The density of PV neurons in the PL (a, b), IL (c, d), and dAC (e, f). PV neuron density at P28 (a, c, e) and P58 (b, d, f) in each area are shown. (a)-(b) The density of PV neurons was increased in L5/6 by sensory deprivation at P56. (c)-(d) The density of PV neurons in L2/3 was decreased at P28 by sensory deprivation, but it was increased in L5/6 at P56. (e)-(f) The density of PV neurons in L5/6 was increased with sensory deprivation at both P28 and P56. Data are expressed as mean density S.E.M. (n = 6 per group). Abbreviations are the same as in Figure 4. ∗P < 0.05 compared with intact mice.
© Copyright Policy - open-access
Related In: Results  -  Collection

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fig4: Sensory deprivation changes PV neuron density in the PFC. The density of PV neurons in the PL (a, b), IL (c, d), and dAC (e, f). PV neuron density at P28 (a, c, e) and P58 (b, d, f) in each area are shown. (a)-(b) The density of PV neurons was increased in L5/6 by sensory deprivation at P56. (c)-(d) The density of PV neurons in L2/3 was decreased at P28 by sensory deprivation, but it was increased in L5/6 at P56. (e)-(f) The density of PV neurons in L5/6 was increased with sensory deprivation at both P28 and P56. Data are expressed as mean density S.E.M. (n = 6 per group). Abbreviations are the same as in Figure 4. ∗P < 0.05 compared with intact mice.
Mentions: There was no change in the density of PV neurons between intact mice and sensory deprived mice in the PL (Figure 4(a)). In L2/3 of the IL, whisker trimming, dark rearing, or dark rearing of whisker trimmed mice significantly decreased PV neuron density (Figure 4(c)). Moreover, whisker trimming significantly decreased PV neuron density in L5/6 of the IL (Figure 4(c)). Whisker trimming, dark rearing, or dark rearing of whisker trimmed mice significantly increased PV neuron density in L5/6 but not in L2/3 of the dAC (Figure 4(e)).

Bottom Line: We determined the effects of sensory deprivation from birth to postnatal day 28 (P28) or P58 on the density of parvalbumin (PV), calbindin (CB), and calretinin (CR) neurons in the prelimbic, infralimbic, and dorsal anterior cingulate cortices.The density of PV and CB neurons was significantly increased in layer 5/6 (L5/6).These results suggest that long-term sensory deprivation causes the changes of intracortical inhibitory networks in the PFC and the changes of inhibitory networks in the PFC may contribute to cross-modal plasticity.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan ; Department of Medical Technology, Kawasaki College of Allied Health Professions, Okayama 701-0194, Japan.

ABSTRACT
Early loss of one sensory system can cause improved function of other sensory systems. However, both the time course and neuronal mechanism of cross-modal plasticity remain elusive. Recent study using functional MRI in humans suggests a role of the prefrontal cortex (PFC) in cross-modal plasticity. Since this phenomenon is assumed to be associated with altered GABAergic inhibition in the PFC, we have tested the hypothesis that early postnatal sensory deprivation causes the changes of inhibitory neuronal circuit in different regions of the PFC of the mice. We determined the effects of sensory deprivation from birth to postnatal day 28 (P28) or P58 on the density of parvalbumin (PV), calbindin (CB), and calretinin (CR) neurons in the prelimbic, infralimbic, and dorsal anterior cingulate cortices. The density of PV and CB neurons was significantly increased in layer 5/6 (L5/6). Moreover, the density of CR neurons was higher in L2/3 in sensory deprived mice compared to intact mice. These changes were more prominent at P56 than at P28. These results suggest that long-term sensory deprivation causes the changes of intracortical inhibitory networks in the PFC and the changes of inhibitory networks in the PFC may contribute to cross-modal plasticity.

No MeSH data available.