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A Case of Spontaneous Tumor Lysis Syndrome in a Patient with Ovarian Cancer.

Okamoto K, Kinoshita T, Shimizu M, Okura I, Kawada A, Mizobuchi K, Ando M - Case Rep Obstet Gynecol (2015)

Bottom Line: We present the novel case of a 62-year-old woman with an ovarian tumor who spontaneously developed TLS.Surgical reduction of the tumor mass vastly improved her condition.As TLS is life-threatening, successful treatments must be seriously considered.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Kagawa Rosai Hospital, 3-3-1 Zyotocho, Marugame-shi, Kagawa-ken 763-8502, Japan.

ABSTRACT
Tumor lysis syndrome (TLS) is a potentially life-threating complication of tumors or chemotherapy treatment. TLS commonly occurs in hematological malignancies, but it is very rare in patients with a solid tumor. In cases of solid tumors, TLS usually occurs spontaneously and after the initiation of anticancer therapy, and it has a high mortality rate. We present the novel case of a 62-year-old woman with an ovarian tumor who spontaneously developed TLS. Surgical reduction of the tumor mass vastly improved her condition. She showed no sign of tumor recurrence 8 months after treatment. As TLS is life-threatening, successful treatments must be seriously considered.

No MeSH data available.


Related in: MedlinePlus

Operative findings. (a) The right ovary is markedly enlarged and contains a carcinoma. (b) The large ovarian tumor is removed via a vertical midline incision after abdominal drainage is performed. (c) The excised tumor mass is 20 cm in diameter. The uterus and left ovary are macroscopically normal. (d) The tumor mass contains septations and papillary solid lesions.
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fig2: Operative findings. (a) The right ovary is markedly enlarged and contains a carcinoma. (b) The large ovarian tumor is removed via a vertical midline incision after abdominal drainage is performed. (c) The excised tumor mass is 20 cm in diameter. The uterus and left ovary are macroscopically normal. (d) The tumor mass contains septations and papillary solid lesions.

Mentions: Following admission, the patient had anuria that responded poorly to aggressive fluid administration. We thought that her presentation could not be explained only by fluid shifts. Two days after admission, laboratory data indicated that her condition had worsened. Her respiratory status declined, and she was placed on a respirator. She also received a vasopressor to maintain her blood pressure. We decided to surgically reduce the amount of the tumor mass and to drain her abdomen in order to improve her condition. Abdominal bilateral salpingo-oophorectomy, hysterectomy, and abdominal drainage were performed (Figure 2).


A Case of Spontaneous Tumor Lysis Syndrome in a Patient with Ovarian Cancer.

Okamoto K, Kinoshita T, Shimizu M, Okura I, Kawada A, Mizobuchi K, Ando M - Case Rep Obstet Gynecol (2015)

Operative findings. (a) The right ovary is markedly enlarged and contains a carcinoma. (b) The large ovarian tumor is removed via a vertical midline incision after abdominal drainage is performed. (c) The excised tumor mass is 20 cm in diameter. The uterus and left ovary are macroscopically normal. (d) The tumor mass contains septations and papillary solid lesions.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4487917&req=5

fig2: Operative findings. (a) The right ovary is markedly enlarged and contains a carcinoma. (b) The large ovarian tumor is removed via a vertical midline incision after abdominal drainage is performed. (c) The excised tumor mass is 20 cm in diameter. The uterus and left ovary are macroscopically normal. (d) The tumor mass contains septations and papillary solid lesions.
Mentions: Following admission, the patient had anuria that responded poorly to aggressive fluid administration. We thought that her presentation could not be explained only by fluid shifts. Two days after admission, laboratory data indicated that her condition had worsened. Her respiratory status declined, and she was placed on a respirator. She also received a vasopressor to maintain her blood pressure. We decided to surgically reduce the amount of the tumor mass and to drain her abdomen in order to improve her condition. Abdominal bilateral salpingo-oophorectomy, hysterectomy, and abdominal drainage were performed (Figure 2).

Bottom Line: We present the novel case of a 62-year-old woman with an ovarian tumor who spontaneously developed TLS.Surgical reduction of the tumor mass vastly improved her condition.As TLS is life-threatening, successful treatments must be seriously considered.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Kagawa Rosai Hospital, 3-3-1 Zyotocho, Marugame-shi, Kagawa-ken 763-8502, Japan.

ABSTRACT
Tumor lysis syndrome (TLS) is a potentially life-threating complication of tumors or chemotherapy treatment. TLS commonly occurs in hematological malignancies, but it is very rare in patients with a solid tumor. In cases of solid tumors, TLS usually occurs spontaneously and after the initiation of anticancer therapy, and it has a high mortality rate. We present the novel case of a 62-year-old woman with an ovarian tumor who spontaneously developed TLS. Surgical reduction of the tumor mass vastly improved her condition. She showed no sign of tumor recurrence 8 months after treatment. As TLS is life-threatening, successful treatments must be seriously considered.

No MeSH data available.


Related in: MedlinePlus