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Organ-Protective Effects of Red Wine Extract, Resveratrol, in Oxidative Stress-Mediated Reperfusion Injury.

Liu FC, Tsai HI, Yu HP - Oxid Med Cell Longev (2015)

Bottom Line: Resveratrol, a polyphenol extracted from red wine, possesses potential antioxidative and anti-inflammatory effects, including the reduction of free radicals and proinflammatory mediators overproduction, the alteration of the expression of adhesion molecules, and the inhibition of neutrophil function.Such protective phenomenon is reported to be implicated in decreasing the formation and reaction of reactive oxygen species and pro-nflammatory cytokines, as well as the mediation of a variety of intracellular signaling pathways, including the nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, deacetylase sirtuin 1, mitogen-activated protein kinase, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, hemeoxygenase-1, and estrogen receptor-related pathways.The resveratrol is an effective reactive oxygen species scavenger that exhibits an antioxidative property.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, Taiwan ; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

ABSTRACT
Resveratrol, a polyphenol extracted from red wine, possesses potential antioxidative and anti-inflammatory effects, including the reduction of free radicals and proinflammatory mediators overproduction, the alteration of the expression of adhesion molecules, and the inhibition of neutrophil function. A growing body of evidence indicates that resveratrol plays an important role in reducing organ damage following ischemia- and hemorrhage-induced reperfusion injury. Such protective phenomenon is reported to be implicated in decreasing the formation and reaction of reactive oxygen species and pro-nflammatory cytokines, as well as the mediation of a variety of intracellular signaling pathways, including the nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, deacetylase sirtuin 1, mitogen-activated protein kinase, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, hemeoxygenase-1, and estrogen receptor-related pathways. Reperfusion injury is a complex pathophysiological process that involves multiple factors and pathways. The resveratrol is an effective reactive oxygen species scavenger that exhibits an antioxidative property. In this review, the organ-protective effects of resveratrol in oxidative stress-related reperfusion injury will be discussed.

No MeSH data available.


Related in: MedlinePlus

The mechanisms and pathways of resveratrol in oxidative stress-mediated ischemia-reperfusion injury. The protective benefits of resveratrol involved are its scavenging, antioxidant, and anti-inflammatory effect and the signaling mechanisms mediated may be via a variety of intracellular signaling pathways, including upregulation of ER-related MAPK/HO-1 and Sirt1/PGC-1α pathway and inhibition of the TLR4 and NF-κB dependent pathway. ROS, reactive oxygen species; ER, estrogen receptor; HO-1, hemeoxygenase 1; SIRT1, sirtuin 1; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; TLR4, Toll-like receptor 4; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha; NF-κB, nuclear factor-kappa B; JNK, c-Jun N-terminal kinase; p38 MAPK, p38 mitogen-activated protein kinase; MMP-9, metallopeptidase 9; SOD, superoxide dismutase; CAT, catalase; GSH, glutathione; GSH-Px, glutathione peroxidase (GSH-Px); NOX, NADPH oxidase; XO, xanthine oxidase; O2−, superoxide anions; HO−, hydroxyl free radicals; H2O2, hydrogen peroxide; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; IL-10, interleukin 10; ICAM-1, intercellular adhesion molecule 1; MPO, myeloperoxidase.
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fig1: The mechanisms and pathways of resveratrol in oxidative stress-mediated ischemia-reperfusion injury. The protective benefits of resveratrol involved are its scavenging, antioxidant, and anti-inflammatory effect and the signaling mechanisms mediated may be via a variety of intracellular signaling pathways, including upregulation of ER-related MAPK/HO-1 and Sirt1/PGC-1α pathway and inhibition of the TLR4 and NF-κB dependent pathway. ROS, reactive oxygen species; ER, estrogen receptor; HO-1, hemeoxygenase 1; SIRT1, sirtuin 1; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; TLR4, Toll-like receptor 4; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha; NF-κB, nuclear factor-kappa B; JNK, c-Jun N-terminal kinase; p38 MAPK, p38 mitogen-activated protein kinase; MMP-9, metallopeptidase 9; SOD, superoxide dismutase; CAT, catalase; GSH, glutathione; GSH-Px, glutathione peroxidase (GSH-Px); NOX, NADPH oxidase; XO, xanthine oxidase; O2−, superoxide anions; HO−, hydroxyl free radicals; H2O2, hydrogen peroxide; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; IL-10, interleukin 10; ICAM-1, intercellular adhesion molecule 1; MPO, myeloperoxidase.

Mentions: Resveratrol has been indicated to have many beneficial effects in various studies and experimental conditions. There is increasing evidence suggesting that resveratrol protects organ function after ischemia or shock-like reperfusion injury. Resveratrol can attenuate organs reperfusion injury through multiple pathways. However, the protective benefits of resveratrol may not simply be attributed by its scavenging, antioxidative, or anti-inflammatory effect. It is implicated that resveratrol is also mediated in part via a variety of intracellular signaling pathways including the regulation of the NOS, HO-1, SIRT1, ER, MAPK, PGC-1α, TLR4, and NF-κB (Figure 1). This complex network needs additional elucidation, more experimental studies, and clinical trials. Resveratrol might be a preventive and therapeutic agent to protect reperfusion-induced organ injury in future clinical treatment.


Organ-Protective Effects of Red Wine Extract, Resveratrol, in Oxidative Stress-Mediated Reperfusion Injury.

Liu FC, Tsai HI, Yu HP - Oxid Med Cell Longev (2015)

The mechanisms and pathways of resveratrol in oxidative stress-mediated ischemia-reperfusion injury. The protective benefits of resveratrol involved are its scavenging, antioxidant, and anti-inflammatory effect and the signaling mechanisms mediated may be via a variety of intracellular signaling pathways, including upregulation of ER-related MAPK/HO-1 and Sirt1/PGC-1α pathway and inhibition of the TLR4 and NF-κB dependent pathway. ROS, reactive oxygen species; ER, estrogen receptor; HO-1, hemeoxygenase 1; SIRT1, sirtuin 1; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; TLR4, Toll-like receptor 4; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha; NF-κB, nuclear factor-kappa B; JNK, c-Jun N-terminal kinase; p38 MAPK, p38 mitogen-activated protein kinase; MMP-9, metallopeptidase 9; SOD, superoxide dismutase; CAT, catalase; GSH, glutathione; GSH-Px, glutathione peroxidase (GSH-Px); NOX, NADPH oxidase; XO, xanthine oxidase; O2−, superoxide anions; HO−, hydroxyl free radicals; H2O2, hydrogen peroxide; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; IL-10, interleukin 10; ICAM-1, intercellular adhesion molecule 1; MPO, myeloperoxidase.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4487914&req=5

fig1: The mechanisms and pathways of resveratrol in oxidative stress-mediated ischemia-reperfusion injury. The protective benefits of resveratrol involved are its scavenging, antioxidant, and anti-inflammatory effect and the signaling mechanisms mediated may be via a variety of intracellular signaling pathways, including upregulation of ER-related MAPK/HO-1 and Sirt1/PGC-1α pathway and inhibition of the TLR4 and NF-κB dependent pathway. ROS, reactive oxygen species; ER, estrogen receptor; HO-1, hemeoxygenase 1; SIRT1, sirtuin 1; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; TLR4, Toll-like receptor 4; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha; NF-κB, nuclear factor-kappa B; JNK, c-Jun N-terminal kinase; p38 MAPK, p38 mitogen-activated protein kinase; MMP-9, metallopeptidase 9; SOD, superoxide dismutase; CAT, catalase; GSH, glutathione; GSH-Px, glutathione peroxidase (GSH-Px); NOX, NADPH oxidase; XO, xanthine oxidase; O2−, superoxide anions; HO−, hydroxyl free radicals; H2O2, hydrogen peroxide; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; IL-10, interleukin 10; ICAM-1, intercellular adhesion molecule 1; MPO, myeloperoxidase.
Mentions: Resveratrol has been indicated to have many beneficial effects in various studies and experimental conditions. There is increasing evidence suggesting that resveratrol protects organ function after ischemia or shock-like reperfusion injury. Resveratrol can attenuate organs reperfusion injury through multiple pathways. However, the protective benefits of resveratrol may not simply be attributed by its scavenging, antioxidative, or anti-inflammatory effect. It is implicated that resveratrol is also mediated in part via a variety of intracellular signaling pathways including the regulation of the NOS, HO-1, SIRT1, ER, MAPK, PGC-1α, TLR4, and NF-κB (Figure 1). This complex network needs additional elucidation, more experimental studies, and clinical trials. Resveratrol might be a preventive and therapeutic agent to protect reperfusion-induced organ injury in future clinical treatment.

Bottom Line: Resveratrol, a polyphenol extracted from red wine, possesses potential antioxidative and anti-inflammatory effects, including the reduction of free radicals and proinflammatory mediators overproduction, the alteration of the expression of adhesion molecules, and the inhibition of neutrophil function.Such protective phenomenon is reported to be implicated in decreasing the formation and reaction of reactive oxygen species and pro-nflammatory cytokines, as well as the mediation of a variety of intracellular signaling pathways, including the nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, deacetylase sirtuin 1, mitogen-activated protein kinase, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, hemeoxygenase-1, and estrogen receptor-related pathways.The resveratrol is an effective reactive oxygen species scavenger that exhibits an antioxidative property.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, Taiwan ; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

ABSTRACT
Resveratrol, a polyphenol extracted from red wine, possesses potential antioxidative and anti-inflammatory effects, including the reduction of free radicals and proinflammatory mediators overproduction, the alteration of the expression of adhesion molecules, and the inhibition of neutrophil function. A growing body of evidence indicates that resveratrol plays an important role in reducing organ damage following ischemia- and hemorrhage-induced reperfusion injury. Such protective phenomenon is reported to be implicated in decreasing the formation and reaction of reactive oxygen species and pro-nflammatory cytokines, as well as the mediation of a variety of intracellular signaling pathways, including the nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, deacetylase sirtuin 1, mitogen-activated protein kinase, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, hemeoxygenase-1, and estrogen receptor-related pathways. Reperfusion injury is a complex pathophysiological process that involves multiple factors and pathways. The resveratrol is an effective reactive oxygen species scavenger that exhibits an antioxidative property. In this review, the organ-protective effects of resveratrol in oxidative stress-related reperfusion injury will be discussed.

No MeSH data available.


Related in: MedlinePlus