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Normal Hearing Ability but Impaired Auditory Selective Attention Associated with Prediction of Response to Donepezil in Patients with Alzheimer's Disease.

Ouchi Y, Meguro K, Akanuma K, Kato Y, Yamaguchi S - Behav Neurol (2015)

Bottom Line: However, ASA test scores decreased in the AD group and were correlated with the vigilance test scores.Donepezil responders (MMSE 3+) also showed improvement on the ASA test.Auditory selective attention is associated with response to donepezil in AD.

View Article: PubMed Central - PubMed

Affiliation: Division of Geriatric Behavioral Neurology, CYRIC, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, IDAC, Sendai 980-8575, Japan.

ABSTRACT

Background: Alzheimer's disease (AD) patients have a poor response to the voices of caregivers. After administration of donepezil, caregivers often find that patients respond more frequently, whereas they had previously pretended to be "deaf." We investigated whether auditory selective attention is associated with response to donepezil.

Methods: The subjects were40 AD patients, 20 elderly healthy controls (HCs), and 15 young HCs. Pure tone audiometry was conducted and an original Auditory Selective Attention (ASA) test was performed with a MoCA vigilance test. Reassessment of the AD group was performed after donepezil treatment for 3 months.

Results: Hearing level of the AD group was the same as that of the elderly HC group. However, ASA test scores decreased in the AD group and were correlated with the vigilance test scores. Donepezil responders (MMSE 3+) also showed improvement on the ASA test. At baseline, the responders had higher vigilance and lower ASA test scores.

Conclusion: Contrary to the common view, AD patients had a similar level of hearing ability to healthy elderly. Auditory attention was impaired in AD patients, which suggests that unnecessary sounds should be avoided in nursing homes. Auditory selective attention is associated with response to donepezil in AD.

No MeSH data available.


Related in: MedlinePlus

Hearing level of three groups. HC: healthy control; AD: Alzheimer's disease. There is a significant group effect (one-way ANOVA, P < 0.01). A post hoc test indicated the group differences (*P < 0.05).
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fig1: Hearing level of three groups. HC: healthy control; AD: Alzheimer's disease. There is a significant group effect (one-way ANOVA, P < 0.01). A post hoc test indicated the group differences (*P < 0.05).

Mentions: As shown in Figure 1, the hearing level in the AD group was about the same as that in the elderly HC group, and both were significantly impaired compared to that of the young HC group. The mean hearing thresholds in all 3 groups did not exceed 20 dB HL at any frequency between 0.125 and 2 kHz in any ear. A mean threshold elevation at 3–8 kHz, not greater than 50 dB HL in any ear, was found in all three groups. There were no significant between-group differences in hearing threshold levels at any frequency or in any ear, and no significant interaural differences; thus mean results for the right-left ears were used.


Normal Hearing Ability but Impaired Auditory Selective Attention Associated with Prediction of Response to Donepezil in Patients with Alzheimer's Disease.

Ouchi Y, Meguro K, Akanuma K, Kato Y, Yamaguchi S - Behav Neurol (2015)

Hearing level of three groups. HC: healthy control; AD: Alzheimer's disease. There is a significant group effect (one-way ANOVA, P < 0.01). A post hoc test indicated the group differences (*P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4487900&req=5

fig1: Hearing level of three groups. HC: healthy control; AD: Alzheimer's disease. There is a significant group effect (one-way ANOVA, P < 0.01). A post hoc test indicated the group differences (*P < 0.05).
Mentions: As shown in Figure 1, the hearing level in the AD group was about the same as that in the elderly HC group, and both were significantly impaired compared to that of the young HC group. The mean hearing thresholds in all 3 groups did not exceed 20 dB HL at any frequency between 0.125 and 2 kHz in any ear. A mean threshold elevation at 3–8 kHz, not greater than 50 dB HL in any ear, was found in all three groups. There were no significant between-group differences in hearing threshold levels at any frequency or in any ear, and no significant interaural differences; thus mean results for the right-left ears were used.

Bottom Line: However, ASA test scores decreased in the AD group and were correlated with the vigilance test scores.Donepezil responders (MMSE 3+) also showed improvement on the ASA test.Auditory selective attention is associated with response to donepezil in AD.

View Article: PubMed Central - PubMed

Affiliation: Division of Geriatric Behavioral Neurology, CYRIC, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, IDAC, Sendai 980-8575, Japan.

ABSTRACT

Background: Alzheimer's disease (AD) patients have a poor response to the voices of caregivers. After administration of donepezil, caregivers often find that patients respond more frequently, whereas they had previously pretended to be "deaf." We investigated whether auditory selective attention is associated with response to donepezil.

Methods: The subjects were40 AD patients, 20 elderly healthy controls (HCs), and 15 young HCs. Pure tone audiometry was conducted and an original Auditory Selective Attention (ASA) test was performed with a MoCA vigilance test. Reassessment of the AD group was performed after donepezil treatment for 3 months.

Results: Hearing level of the AD group was the same as that of the elderly HC group. However, ASA test scores decreased in the AD group and were correlated with the vigilance test scores. Donepezil responders (MMSE 3+) also showed improvement on the ASA test. At baseline, the responders had higher vigilance and lower ASA test scores.

Conclusion: Contrary to the common view, AD patients had a similar level of hearing ability to healthy elderly. Auditory attention was impaired in AD patients, which suggests that unnecessary sounds should be avoided in nursing homes. Auditory selective attention is associated with response to donepezil in AD.

No MeSH data available.


Related in: MedlinePlus