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Inflammatory Response to Sorbent Hemodialysis.

Rosales L, Thijssen S, Kruse A, Sipahioglu MH, Hirachan P, Raimann JG, Kuntsevich V, Carter M, Levin NW, Kotanko P - ASAIO J. (2015 Jul-Aug)

Bottom Line: Dialysate volume is substantially reduced in sorbent HD compared with standard single-pass dialysis.Midweek pre- and post-HD serum levels of high-sensitivity C-reactive protein, interleukin (IL)-1β, IL-6, IL-10, interferon gamma, tumor necrosis factor alpha (TNF-α), and eotaxin were determined and their intradialytic change corrected for hemoconcentration during single-pass HD and sorbent HD compared by paired t-test.Although TNF-α decreased during both single-pass and sorbent HD (p < 0.001), none of the other biomarkers changed significantly during HD.

View Article: PubMed Central - PubMed

Affiliation: From the *Renal Research Institute, New York, New York; †Mount Sinai Beth Israel, New York, New York; ‡Agarwal Nephrology and Hypertension PC, Columbus, Georgia; §Nephrology, Spitalzentrum, Biel, Switzerland; and ¶Erciyes Medical University, Nephrology, Kayseri, Turkey.

ABSTRACT
Inflammation is common and associated with morbidity and mortality in hemodialysis (HD) patients. Exposure to endotoxin contained in the dialysate may trigger inflammation. Dialysate volume is substantially reduced in sorbent HD compared with standard single-pass dialysis. In this prospective study (Clinicaltrials.gov, number: NCT00788905), we compared the inflammatory response to single-pass and sorbent HD. Patients receiving single-pass HD were studied during 1 week of sorbent HD (Allient system; Renal Solutions, Warrendale, PA) and 1 week of single-pass HD. Patients were dialyzed using high-flux polysulfone dialyzers. Midweek pre- and post-HD serum levels of high-sensitivity C-reactive protein, interleukin (IL)-1β, IL-6, IL-10, interferon gamma, tumor necrosis factor alpha (TNF-α), and eotaxin were determined and their intradialytic change corrected for hemoconcentration during single-pass HD and sorbent HD compared by paired t-test. We enrolled 18 patients, nine completed the study. Although TNF-α decreased during both single-pass and sorbent HD (p < 0.001), none of the other biomarkers changed significantly during HD. We observed no difference between single-pass and sorbent HD. For the markers investigated in this study, there was no difference in the acute intradialytic inflammatory response to single-pass or sorbent HD.

No MeSH data available.


Related in: MedlinePlus

Intradialytic changes of biomarkers of inflammation during single-pass hemodialysis (red), sorbent hemodialysis (green), and the difference between these changes (blue). The data indicate means and 95% confidence intervals. hs-CRP: high-sensitivity C-reactive protein.
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Related In: Results  -  Collection


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Figure 2: Intradialytic changes of biomarkers of inflammation during single-pass hemodialysis (red), sorbent hemodialysis (green), and the difference between these changes (blue). The data indicate means and 95% confidence intervals. hs-CRP: high-sensitivity C-reactive protein.


Inflammatory Response to Sorbent Hemodialysis.

Rosales L, Thijssen S, Kruse A, Sipahioglu MH, Hirachan P, Raimann JG, Kuntsevich V, Carter M, Levin NW, Kotanko P - ASAIO J. (2015 Jul-Aug)

Intradialytic changes of biomarkers of inflammation during single-pass hemodialysis (red), sorbent hemodialysis (green), and the difference between these changes (blue). The data indicate means and 95% confidence intervals. hs-CRP: high-sensitivity C-reactive protein.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4487872&req=5

Figure 2: Intradialytic changes of biomarkers of inflammation during single-pass hemodialysis (red), sorbent hemodialysis (green), and the difference between these changes (blue). The data indicate means and 95% confidence intervals. hs-CRP: high-sensitivity C-reactive protein.
Bottom Line: Dialysate volume is substantially reduced in sorbent HD compared with standard single-pass dialysis.Midweek pre- and post-HD serum levels of high-sensitivity C-reactive protein, interleukin (IL)-1β, IL-6, IL-10, interferon gamma, tumor necrosis factor alpha (TNF-α), and eotaxin were determined and their intradialytic change corrected for hemoconcentration during single-pass HD and sorbent HD compared by paired t-test.Although TNF-α decreased during both single-pass and sorbent HD (p < 0.001), none of the other biomarkers changed significantly during HD.

View Article: PubMed Central - PubMed

Affiliation: From the *Renal Research Institute, New York, New York; †Mount Sinai Beth Israel, New York, New York; ‡Agarwal Nephrology and Hypertension PC, Columbus, Georgia; §Nephrology, Spitalzentrum, Biel, Switzerland; and ¶Erciyes Medical University, Nephrology, Kayseri, Turkey.

ABSTRACT
Inflammation is common and associated with morbidity and mortality in hemodialysis (HD) patients. Exposure to endotoxin contained in the dialysate may trigger inflammation. Dialysate volume is substantially reduced in sorbent HD compared with standard single-pass dialysis. In this prospective study (Clinicaltrials.gov, number: NCT00788905), we compared the inflammatory response to single-pass and sorbent HD. Patients receiving single-pass HD were studied during 1 week of sorbent HD (Allient system; Renal Solutions, Warrendale, PA) and 1 week of single-pass HD. Patients were dialyzed using high-flux polysulfone dialyzers. Midweek pre- and post-HD serum levels of high-sensitivity C-reactive protein, interleukin (IL)-1β, IL-6, IL-10, interferon gamma, tumor necrosis factor alpha (TNF-α), and eotaxin were determined and their intradialytic change corrected for hemoconcentration during single-pass HD and sorbent HD compared by paired t-test. We enrolled 18 patients, nine completed the study. Although TNF-α decreased during both single-pass and sorbent HD (p < 0.001), none of the other biomarkers changed significantly during HD. We observed no difference between single-pass and sorbent HD. For the markers investigated in this study, there was no difference in the acute intradialytic inflammatory response to single-pass or sorbent HD.

No MeSH data available.


Related in: MedlinePlus