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Evaluation of diagnostic criteria for IgG4-related tubulointerstitial nephritis.

Tang X, Zhu B, Chen R, Hu Y, Zhang Y, Zhu X, Chen H, Wang Y - Diagn Pathol (2015)

Bottom Line: The other was CreGN with immune complex deposits, which had poor outcome and long-term hemodialysis.The proposed criteria by the Mayo Clinic is flexible, sensitive, and superior in the identification of early-stage or atypical IgG4-TIN, with enhanced risk of misdiagnosis as compared to the proposed criteria by JSN, which is stricter, more specific, and might overlook early-stage or atypical IgG4-TIN.We propose a new set of criteria to improve pathologist-derived diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology (Key laboratory of Zhejiang province, management of kidney disease), Hangzhou hospital of traditional Chinese medicine, Hangzhou, 310007, China. tangsunshine1981168@sina.com.

ABSTRACT

Background: IgG4-TIN is the most common pattern of renal involvement in IgG4-related disease. There are several proposed diagnostic criteria of IgG4-TIN recently. Two of them proposed by the Mayo Clinic and JSN are predominant. However, histopathological criteria of the number of IgG4+ plasma cells and several histological features are still under discussion due to low amount of tissue in renal biopsy specimens and low frequency of this kind of specimens. We aimed to screen IgG4-TIN on archived renal biopsy samples and evaluated the application of two proposed diagnostic criteria.

Methods: We selected 480 interstitial inflammation samples for light and electron microscopy and immunohistochemistry of CD138, IgG and IgG4 test. The Mayo Clinic proposed criteria diagnosed high-probability IgG4-TIN and JSN criteria confirmed IgG4-TIN.

Results: Twelve high-probability IgG4-TIN were screened by histology, imaging, serology and other organ involvement according to the Mayo Clinic proposed criteria. The previous principal pathological diagnoses were IgAN (n=4), CreGN (n=4), tubulointerstitial nephritis (n=3) and LN (n=1). Three cases showed storiform fibrosis and a bird's eye pattern. The distribution of IgG4+ plasma cells was focal, multifocal or diffuse, with a mixed mild, moderate or strong stainingpattern. Their treatment and clinical outcomes varied depending on different levels of proteinuria, serum creatinine, eGFR and original glomerular disease presentation. Therefore, we applied strict histological criteria of storiform fibrosis and evenly distributed IgG4+ plasma cells by JSN to confirm typical IgG4-TIN. Two cases were finally diagnosed as real IgG4-TIN. One was previously diagnosed as idiopathic interstitial nephritis with rapid response to corticosteroid therapy. The other was CreGN with immune complex deposits, which had poor outcome and long-term hemodialysis.

Conclusions: IgG4-TIN might present concurrently with glomerular disease. The proposed criteria by the Mayo Clinic is flexible, sensitive, and superior in the identification of early-stage or atypical IgG4-TIN, with enhanced risk of misdiagnosis as compared to the proposed criteria by JSN, which is stricter, more specific, and might overlook early-stage or atypical IgG4-TIN. We propose a new set of criteria to improve pathologist-derived diagnosis.

No MeSH data available.


Related in: MedlinePlus

The procedure of screening cases
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Fig1: The procedure of screening cases

Mentions: The procedure of screening cases is shown in Fig. 1. Herein, 480 samples with sufficient interstitial inflammation that accounted for 24.2 % of total renal biopsy specimens were selected in our study. After re-observing these specimens by light microscopy, 55 cases demonstrating abundant plasma cells were screened. Furthermore, 21 cases of suspected IgG4-TIN were screened from the previous group by CD138, IgG and IgG4 test, which accounted for 38.2 % of abundant plasma cell cases and 4.4 % of sufficient inflammation cases. The average number of CD138, IgG and IgG4 positive cells were 75.8 ± 34.9, 34.0 ± 21.3 and 19.9 ± 13.3 respectively. Their predominant pathological diagnoses were IgAN, CreGN and TIN respectively, whilst others were FSGS, LN, MN and SS.Fig. 1


Evaluation of diagnostic criteria for IgG4-related tubulointerstitial nephritis.

Tang X, Zhu B, Chen R, Hu Y, Zhang Y, Zhu X, Chen H, Wang Y - Diagn Pathol (2015)

The procedure of screening cases
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4487857&req=5

Fig1: The procedure of screening cases
Mentions: The procedure of screening cases is shown in Fig. 1. Herein, 480 samples with sufficient interstitial inflammation that accounted for 24.2 % of total renal biopsy specimens were selected in our study. After re-observing these specimens by light microscopy, 55 cases demonstrating abundant plasma cells were screened. Furthermore, 21 cases of suspected IgG4-TIN were screened from the previous group by CD138, IgG and IgG4 test, which accounted for 38.2 % of abundant plasma cell cases and 4.4 % of sufficient inflammation cases. The average number of CD138, IgG and IgG4 positive cells were 75.8 ± 34.9, 34.0 ± 21.3 and 19.9 ± 13.3 respectively. Their predominant pathological diagnoses were IgAN, CreGN and TIN respectively, whilst others were FSGS, LN, MN and SS.Fig. 1

Bottom Line: The other was CreGN with immune complex deposits, which had poor outcome and long-term hemodialysis.The proposed criteria by the Mayo Clinic is flexible, sensitive, and superior in the identification of early-stage or atypical IgG4-TIN, with enhanced risk of misdiagnosis as compared to the proposed criteria by JSN, which is stricter, more specific, and might overlook early-stage or atypical IgG4-TIN.We propose a new set of criteria to improve pathologist-derived diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology (Key laboratory of Zhejiang province, management of kidney disease), Hangzhou hospital of traditional Chinese medicine, Hangzhou, 310007, China. tangsunshine1981168@sina.com.

ABSTRACT

Background: IgG4-TIN is the most common pattern of renal involvement in IgG4-related disease. There are several proposed diagnostic criteria of IgG4-TIN recently. Two of them proposed by the Mayo Clinic and JSN are predominant. However, histopathological criteria of the number of IgG4+ plasma cells and several histological features are still under discussion due to low amount of tissue in renal biopsy specimens and low frequency of this kind of specimens. We aimed to screen IgG4-TIN on archived renal biopsy samples and evaluated the application of two proposed diagnostic criteria.

Methods: We selected 480 interstitial inflammation samples for light and electron microscopy and immunohistochemistry of CD138, IgG and IgG4 test. The Mayo Clinic proposed criteria diagnosed high-probability IgG4-TIN and JSN criteria confirmed IgG4-TIN.

Results: Twelve high-probability IgG4-TIN were screened by histology, imaging, serology and other organ involvement according to the Mayo Clinic proposed criteria. The previous principal pathological diagnoses were IgAN (n=4), CreGN (n=4), tubulointerstitial nephritis (n=3) and LN (n=1). Three cases showed storiform fibrosis and a bird's eye pattern. The distribution of IgG4+ plasma cells was focal, multifocal or diffuse, with a mixed mild, moderate or strong stainingpattern. Their treatment and clinical outcomes varied depending on different levels of proteinuria, serum creatinine, eGFR and original glomerular disease presentation. Therefore, we applied strict histological criteria of storiform fibrosis and evenly distributed IgG4+ plasma cells by JSN to confirm typical IgG4-TIN. Two cases were finally diagnosed as real IgG4-TIN. One was previously diagnosed as idiopathic interstitial nephritis with rapid response to corticosteroid therapy. The other was CreGN with immune complex deposits, which had poor outcome and long-term hemodialysis.

Conclusions: IgG4-TIN might present concurrently with glomerular disease. The proposed criteria by the Mayo Clinic is flexible, sensitive, and superior in the identification of early-stage or atypical IgG4-TIN, with enhanced risk of misdiagnosis as compared to the proposed criteria by JSN, which is stricter, more specific, and might overlook early-stage or atypical IgG4-TIN. We propose a new set of criteria to improve pathologist-derived diagnosis.

No MeSH data available.


Related in: MedlinePlus