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Brain Network Response to Acupuncture Stimuli in Experimental Acute Low Back Pain: An fMRI Study.

Shi Y, Liu Z, Zhang S, Li Q, Guo S, Yang J, Wu W - Evid Based Complement Alternat Med (2015)

Bottom Line: Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain.Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects.Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

ABSTRACT
Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain. In the current study, we combined an experimental acute low back pain (ALBP) model and functional magnetic resonance imaging (fMRI) to explore the neural mechanisms of acupuncture analgesia. All ALBP subjects first underwent two resting state fMRI scans at baseline and during a painful episode and then underwent two additional fMRI scans, once during acupuncture stimulation (ACUP) and once during tactile stimulation (SHAM) pseudorandomly, at the BL40 acupoint. Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects. Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.

No MeSH data available.


Related in: MedlinePlus

The fMRI signal increases and decreases in cortical and subcortical brain structures, (1) PAG; (2) pACC, aMCC, and anterior dmPFC; (3) PHP and HP; (4) PCN, PCC, and RSC; (5) striatum, thalamus, red nucleus, and substantia nigra; (6) lateral temporal cortex; (7) pMCC; (8) mammillary body.
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fig7: The fMRI signal increases and decreases in cortical and subcortical brain structures, (1) PAG; (2) pACC, aMCC, and anterior dmPFC; (3) PHP and HP; (4) PCN, PCC, and RSC; (5) striatum, thalamus, red nucleus, and substantia nigra; (6) lateral temporal cortex; (7) pMCC; (8) mammillary body.

Mentions: Compared with the OFF status, ACUP significantly affected the activations and deactivations; deactivations were found in the somatosensory system (left primary motor cortex (M1), S2, and frontal eye field), limbic system (left insula and mammillary body, right hippocampus (HP), bilateral dmPFC, pregenual ACC (pACC), PAG, and PHP), pain matrix (left S1, left insular, temporal lobe, and frontal lobe), DMN (right angular gyrus, supramarginal gyrus, lateral temporal cortex, HP, bilateral dmPFC, and PHP), and bilateral thalamus. The activations, including the right M1, S1, and bilateral supplementary motor areas, right insula, and pMCC, were limited (P < 0.05, FDR < 0.05, Table 2, Figures 7 and 8).


Brain Network Response to Acupuncture Stimuli in Experimental Acute Low Back Pain: An fMRI Study.

Shi Y, Liu Z, Zhang S, Li Q, Guo S, Yang J, Wu W - Evid Based Complement Alternat Med (2015)

The fMRI signal increases and decreases in cortical and subcortical brain structures, (1) PAG; (2) pACC, aMCC, and anterior dmPFC; (3) PHP and HP; (4) PCN, PCC, and RSC; (5) striatum, thalamus, red nucleus, and substantia nigra; (6) lateral temporal cortex; (7) pMCC; (8) mammillary body.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4487721&req=5

fig7: The fMRI signal increases and decreases in cortical and subcortical brain structures, (1) PAG; (2) pACC, aMCC, and anterior dmPFC; (3) PHP and HP; (4) PCN, PCC, and RSC; (5) striatum, thalamus, red nucleus, and substantia nigra; (6) lateral temporal cortex; (7) pMCC; (8) mammillary body.
Mentions: Compared with the OFF status, ACUP significantly affected the activations and deactivations; deactivations were found in the somatosensory system (left primary motor cortex (M1), S2, and frontal eye field), limbic system (left insula and mammillary body, right hippocampus (HP), bilateral dmPFC, pregenual ACC (pACC), PAG, and PHP), pain matrix (left S1, left insular, temporal lobe, and frontal lobe), DMN (right angular gyrus, supramarginal gyrus, lateral temporal cortex, HP, bilateral dmPFC, and PHP), and bilateral thalamus. The activations, including the right M1, S1, and bilateral supplementary motor areas, right insula, and pMCC, were limited (P < 0.05, FDR < 0.05, Table 2, Figures 7 and 8).

Bottom Line: Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain.Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects.Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

ABSTRACT
Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain. In the current study, we combined an experimental acute low back pain (ALBP) model and functional magnetic resonance imaging (fMRI) to explore the neural mechanisms of acupuncture analgesia. All ALBP subjects first underwent two resting state fMRI scans at baseline and during a painful episode and then underwent two additional fMRI scans, once during acupuncture stimulation (ACUP) and once during tactile stimulation (SHAM) pseudorandomly, at the BL40 acupoint. Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects. Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.

No MeSH data available.


Related in: MedlinePlus