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Brain Network Response to Acupuncture Stimuli in Experimental Acute Low Back Pain: An fMRI Study.

Shi Y, Liu Z, Zhang S, Li Q, Guo S, Yang J, Wu W - Evid Based Complement Alternat Med (2015)

Bottom Line: Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain.Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects.Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

ABSTRACT
Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain. In the current study, we combined an experimental acute low back pain (ALBP) model and functional magnetic resonance imaging (fMRI) to explore the neural mechanisms of acupuncture analgesia. All ALBP subjects first underwent two resting state fMRI scans at baseline and during a painful episode and then underwent two additional fMRI scans, once during acupuncture stimulation (ACUP) and once during tactile stimulation (SHAM) pseudorandomly, at the BL40 acupoint. Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects. Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.

No MeSH data available.


Related in: MedlinePlus

Results of psychophysical analysis in ACUP and SHAM. For ALBP subjects, there were significant differences between the ACUP and SHAM in the mean value of posttreatment pain (P = 0.043), soreness (P = 0.014), and fullness (P = 0.001).
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fig5: Results of psychophysical analysis in ACUP and SHAM. For ALBP subjects, there were significant differences between the ACUP and SHAM in the mean value of posttreatment pain (P = 0.043), soreness (P = 0.014), and fullness (P = 0.001).

Mentions: The intensity of the lower back pain and de qi sensations are expressed below as mean ± standard deviation. Soreness, numbness, fullness, and heaviness were the primary de qi sensations in the current study. In the ALBP group, the mean values of pretreatment LBP were 5.40 (S.D. = 0.98) and 5.60 (S.D. = 1.24) and those of posttreatment LBP were 3.47 (S.D. = 0.75) and 4.51 (S.D. = 1.06) for ACUP and SHAM, respectively. There were significant differences in the score for the soreness and fullness between ACUP and SHAM for ALBP subjects (Figure 5).


Brain Network Response to Acupuncture Stimuli in Experimental Acute Low Back Pain: An fMRI Study.

Shi Y, Liu Z, Zhang S, Li Q, Guo S, Yang J, Wu W - Evid Based Complement Alternat Med (2015)

Results of psychophysical analysis in ACUP and SHAM. For ALBP subjects, there were significant differences between the ACUP and SHAM in the mean value of posttreatment pain (P = 0.043), soreness (P = 0.014), and fullness (P = 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4487721&req=5

fig5: Results of psychophysical analysis in ACUP and SHAM. For ALBP subjects, there were significant differences between the ACUP and SHAM in the mean value of posttreatment pain (P = 0.043), soreness (P = 0.014), and fullness (P = 0.001).
Mentions: The intensity of the lower back pain and de qi sensations are expressed below as mean ± standard deviation. Soreness, numbness, fullness, and heaviness were the primary de qi sensations in the current study. In the ALBP group, the mean values of pretreatment LBP were 5.40 (S.D. = 0.98) and 5.60 (S.D. = 1.24) and those of posttreatment LBP were 3.47 (S.D. = 0.75) and 4.51 (S.D. = 1.06) for ACUP and SHAM, respectively. There were significant differences in the score for the soreness and fullness between ACUP and SHAM for ALBP subjects (Figure 5).

Bottom Line: Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain.Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects.Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

ABSTRACT
Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain. In the current study, we combined an experimental acute low back pain (ALBP) model and functional magnetic resonance imaging (fMRI) to explore the neural mechanisms of acupuncture analgesia. All ALBP subjects first underwent two resting state fMRI scans at baseline and during a painful episode and then underwent two additional fMRI scans, once during acupuncture stimulation (ACUP) and once during tactile stimulation (SHAM) pseudorandomly, at the BL40 acupoint. Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects. Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.

No MeSH data available.


Related in: MedlinePlus