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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study.

Drumond Marra HL, Myczkowski ML, Maia Memória C, Arnaut D, Leite Ribeiro P, Sardinha Mansur CG, Lancelote Alberto R, Boura Bellini B, Alves Fernandes da Silva A, Tortella G, Ciampi de Andrade D, Teixeira MJ, Forlenza OV, Marcolin MA - Behav Neurol (2015)

Bottom Line: This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI.ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group.These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.

View Article: PubMed Central - PubMed

Affiliation: Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.

ABSTRACT
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.

No MeSH data available.


Related in: MedlinePlus

Comparison of semantic verbal fluency/animal naming means scores in T0, T1, and T2. Two-way ANOVA for repeated measures. Timing of procedures: T0: baseline cognitive assessment and 1st rTMS; T1: 10th rTMS session and 2nd cognitive assessment; T2: 30 days after T1 and 3rd cognitive assessment. Student's t-test for comparison of rTMS versus sham basal means, p = 0.081.
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fig6: Comparison of semantic verbal fluency/animal naming means scores in T0, T1, and T2. Two-way ANOVA for repeated measures. Timing of procedures: T0: baseline cognitive assessment and 1st rTMS; T1: 10th rTMS session and 2nd cognitive assessment; T2: 30 days after T1 and 3rd cognitive assessment. Student's t-test for comparison of rTMS versus sham basal means, p = 0.081.

Mentions: Transient improvement was observed in the sham group in verbal fluency/animal naming, at T2. However, the final scores were similar in both groups and quite heterogeneous in T0 (Figure 6).


Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study.

Drumond Marra HL, Myczkowski ML, Maia Memória C, Arnaut D, Leite Ribeiro P, Sardinha Mansur CG, Lancelote Alberto R, Boura Bellini B, Alves Fernandes da Silva A, Tortella G, Ciampi de Andrade D, Teixeira MJ, Forlenza OV, Marcolin MA - Behav Neurol (2015)

Comparison of semantic verbal fluency/animal naming means scores in T0, T1, and T2. Two-way ANOVA for repeated measures. Timing of procedures: T0: baseline cognitive assessment and 1st rTMS; T1: 10th rTMS session and 2nd cognitive assessment; T2: 30 days after T1 and 3rd cognitive assessment. Student's t-test for comparison of rTMS versus sham basal means, p = 0.081.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4487699&req=5

fig6: Comparison of semantic verbal fluency/animal naming means scores in T0, T1, and T2. Two-way ANOVA for repeated measures. Timing of procedures: T0: baseline cognitive assessment and 1st rTMS; T1: 10th rTMS session and 2nd cognitive assessment; T2: 30 days after T1 and 3rd cognitive assessment. Student's t-test for comparison of rTMS versus sham basal means, p = 0.081.
Mentions: Transient improvement was observed in the sham group in verbal fluency/animal naming, at T2. However, the final scores were similar in both groups and quite heterogeneous in T0 (Figure 6).

Bottom Line: This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI.ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group.These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.

View Article: PubMed Central - PubMed

Affiliation: Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.

ABSTRACT
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.

No MeSH data available.


Related in: MedlinePlus