Limits...
Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study.

Drumond Marra HL, Myczkowski ML, Maia Memória C, Arnaut D, Leite Ribeiro P, Sardinha Mansur CG, Lancelote Alberto R, Boura Bellini B, Alves Fernandes da Silva A, Tortella G, Ciampi de Andrade D, Teixeira MJ, Forlenza OV, Marcolin MA - Behav Neurol (2015)

Bottom Line: This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI.ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group.These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.

View Article: PubMed Central - PubMed

Affiliation: Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.

ABSTRACT
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of referred and enrolled patients.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4487699&req=5

fig1: Flow diagram of referred and enrolled patients.

Mentions: Out of 109 screened subjects, 73 did not fulfill the enrollment criteria. Among the 36 subjects left, 17 were randomly assigned to the active group and 19 to the sham group. In the active group, two drop-out subjects, after the first session, were excluded due to inability to follow the protocol. Therefore, 34 subjects entered the treatment phase (Figure 1). Among them, 31 were classified as a-MCI and three as nonamnesic-MCI (two in the sham group and one in the active group).


Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study.

Drumond Marra HL, Myczkowski ML, Maia Memória C, Arnaut D, Leite Ribeiro P, Sardinha Mansur CG, Lancelote Alberto R, Boura Bellini B, Alves Fernandes da Silva A, Tortella G, Ciampi de Andrade D, Teixeira MJ, Forlenza OV, Marcolin MA - Behav Neurol (2015)

Flow diagram of referred and enrolled patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4487699&req=5

fig1: Flow diagram of referred and enrolled patients.
Mentions: Out of 109 screened subjects, 73 did not fulfill the enrollment criteria. Among the 36 subjects left, 17 were randomly assigned to the active group and 19 to the sham group. In the active group, two drop-out subjects, after the first session, were excluded due to inability to follow the protocol. Therefore, 34 subjects entered the treatment phase (Figure 1). Among them, 31 were classified as a-MCI and three as nonamnesic-MCI (two in the sham group and one in the active group).

Bottom Line: This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI.ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group.These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.

View Article: PubMed Central - PubMed

Affiliation: Transcranial Magnetic Stimulation Laboratory, Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Rua Dr. Ovidio Pires de Campos 785, 05402-010 São Paulo, SP, Brazil.

ABSTRACT
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.

No MeSH data available.


Related in: MedlinePlus