The dormant blood microbiome in chronic, inflammatory diseases.
Bottom Line: The chief origin of these microbes is the gut microbiome (especially when it shifts composition to a pathogenic state, known as 'dysbiosis').Another source is microbes translocated from the oral cavity. 'Dysbiosis' is also used to describe translocation of cells into blood or other tissues.To avoid ambiguity, we here use the term 'atopobiosis' for microbes that appear in places other than their normal location.
Affiliation: Department of Physiology, Faculty of Health Sciences, University of Pretoria, Arcadia 0007, South Africa.Show MeSH
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Mentions: TEM analysis of the samples from Lipinski and Pretorius (2013) and Pretorius et al. (2014a) showed the presence inside RBCs of cells that appeared to be microbial in nature (unpublished data). These internalized cells further provide evidence for a sustained presence of such a blood microbiota (and one hardly explained by contamination) (see Fig. 7A and B: AD and C and D: PD). Bacteria are shown with arrows in the micrographs. No bacterial membrane was noted; therefore, the bacteria may be L-forms. There seems to be bacterial species selectivity for a given disease, as our preliminary observations suggest a prevalence for bacillus-type bacteria in AD, but both coccus- and bacillus-shaped bacteria in PD patients.
Affiliation: Department of Physiology, Faculty of Health Sciences, University of Pretoria, Arcadia 0007, South Africa.