One cannot rule them all: Are bacterial toxins-antitoxins druggable?
Bottom Line: The result is a cessation of cell growth or even death.Appropriate fragments could disrupt the T:A interfaces leading to the release of the targeted TA pair.Possible ways of delivery and formulation of Tas are also discussed.
Affiliation: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28006-Madrid, Spain.Show MeSH
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Mentions: A number of different strategies have been suggested as possible means to the druggability of toxins (Mutschler and Meinhart 2011; Chan et al., 2013; Gerdes 2013; Unterholzner, Poppenberger and Rozhon 2013). These strategies are based on the finding that the antitoxin is more susceptible to degradation by the host proteases than its cognate toxin. Therefore, by inhibiting the replenishment of the antitoxin, the toxin will be released and can exhibit its toxicity to the cells while its cognate antitoxin is degraded. We can conceive a number of strategies, all having their pros and cons, as schematized in Fig. 5.
Affiliation: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28006-Madrid, Spain.