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Calibration of Traceable Solid Mock (131)I Phantoms Used in an International SPECT Image Quantification Comparison.

Zimmerman BE, Pibida L, King LE, Bergeron DE, Cessna JT, Mille MM - J Res Natl Inst Stand Technol (2013)

Bottom Line: For this study, we designed a set of solid cylindrical sources so that each site could have a set of phantoms (having nominal volumes of 2 mL, 4 mL, 6 mL, and 23 mL) with traceable activity calibrations so that the results could be properly compared.We also developed a technique using two different detection methods for individually calibrating the sources for (133)Ba activity based on a National standard.This methodology allows for the activity calibration of each (133)Ba source with a standard uncertainty on the activity of 1.4 % for the high-level 2-, 4-, and 6-mL sources and 1.7 % for the lower-level 23 mL cylinders.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Standards and Technology, Gaithersburg, MD 20899.

ABSTRACT
The International Atomic Energy Agency (IAEA) has organized an international comparison to assess Single Photon Emission Computed Tomography (SPECT) image quantification capabilities in 12 countries. Iodine-131 was chosen as the radionuclide for the comparison because of its wide use around the world, but for logistical reasons solid (133)Ba sources were used as a long-lived surrogate for (131)I. For this study, we designed a set of solid cylindrical sources so that each site could have a set of phantoms (having nominal volumes of 2 mL, 4 mL, 6 mL, and 23 mL) with traceable activity calibrations so that the results could be properly compared. We also developed a technique using two different detection methods for individually calibrating the sources for (133)Ba activity based on a National standard. This methodology allows for the activity calibration of each (133)Ba source with a standard uncertainty on the activity of 1.4 % for the high-level 2-, 4-, and 6-mL sources and 1.7 % for the lower-level 23 mL cylinders. This level of uncertainty allows for these sources to be used for the intended comparison exercise, as well as in other SPECT image quantification studies.

No MeSH data available.


Photograph of a set of 133Ba epoxy sources prepared for and calibrated in this study. The sources appear dark due to a dye that was added to the epoxy during manufacturing as a visual indicator of uniform mixing.
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f1-jres.118.017: Photograph of a set of 133Ba epoxy sources prepared for and calibrated in this study. The sources appear dark due to a dye that was added to the epoxy during manufacturing as a visual indicator of uniform mixing.

Mentions: After weighing at NIST, the sources were solvent-sealed and measured for total contained activity as described below. A set of the epoxy sources can be seen in Fig. 1.


Calibration of Traceable Solid Mock (131)I Phantoms Used in an International SPECT Image Quantification Comparison.

Zimmerman BE, Pibida L, King LE, Bergeron DE, Cessna JT, Mille MM - J Res Natl Inst Stand Technol (2013)

Photograph of a set of 133Ba epoxy sources prepared for and calibrated in this study. The sources appear dark due to a dye that was added to the epoxy during manufacturing as a visual indicator of uniform mixing.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4487311&req=5

f1-jres.118.017: Photograph of a set of 133Ba epoxy sources prepared for and calibrated in this study. The sources appear dark due to a dye that was added to the epoxy during manufacturing as a visual indicator of uniform mixing.
Mentions: After weighing at NIST, the sources were solvent-sealed and measured for total contained activity as described below. A set of the epoxy sources can be seen in Fig. 1.

Bottom Line: For this study, we designed a set of solid cylindrical sources so that each site could have a set of phantoms (having nominal volumes of 2 mL, 4 mL, 6 mL, and 23 mL) with traceable activity calibrations so that the results could be properly compared.We also developed a technique using two different detection methods for individually calibrating the sources for (133)Ba activity based on a National standard.This methodology allows for the activity calibration of each (133)Ba source with a standard uncertainty on the activity of 1.4 % for the high-level 2-, 4-, and 6-mL sources and 1.7 % for the lower-level 23 mL cylinders.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Standards and Technology, Gaithersburg, MD 20899.

ABSTRACT
The International Atomic Energy Agency (IAEA) has organized an international comparison to assess Single Photon Emission Computed Tomography (SPECT) image quantification capabilities in 12 countries. Iodine-131 was chosen as the radionuclide for the comparison because of its wide use around the world, but for logistical reasons solid (133)Ba sources were used as a long-lived surrogate for (131)I. For this study, we designed a set of solid cylindrical sources so that each site could have a set of phantoms (having nominal volumes of 2 mL, 4 mL, 6 mL, and 23 mL) with traceable activity calibrations so that the results could be properly compared. We also developed a technique using two different detection methods for individually calibrating the sources for (133)Ba activity based on a National standard. This methodology allows for the activity calibration of each (133)Ba source with a standard uncertainty on the activity of 1.4 % for the high-level 2-, 4-, and 6-mL sources and 1.7 % for the lower-level 23 mL cylinders. This level of uncertainty allows for these sources to be used for the intended comparison exercise, as well as in other SPECT image quantification studies.

No MeSH data available.