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Effect of Acupuncture on Functional Connectivity of Anterior Cingulate Cortex for Bell's Palsy Patients with Different Clinical Duration.

Wu H, Kan H, Li C, Park K, Zhu Y, Mohamed AZ, Xu C, Wu Y, Zhang W, Yang J - Evid Based Complement Alternat Med (2015)

Bottom Line: In order to explore the potential mechanism, changes of functional connectivity (FC) of anterior cingulate gyrus (ACC) were investigated.We collected 20 healthy (control group) participants and 28 BP patients with different clinical duration accepted resting state functional MRI (rfMRI) scans before and after acupuncture, respectively.The FC of ACC before and after acupuncture was compared with paired t-test and the detailed results are presented in the paper.

View Article: PubMed Central - PubMed

Affiliation: Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China ; Laboratory of Digital Medical Imaging, Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China.

ABSTRACT
Acupuncture is widely used in the treatment of Bell's palsy (BP) in many countries, but its underlying physiological mechanism remained controversial. In order to explore the potential mechanism, changes of functional connectivity (FC) of anterior cingulate gyrus (ACC) were investigated. We collected 20 healthy (control group) participants and 28 BP patients with different clinical duration accepted resting state functional MRI (rfMRI) scans before and after acupuncture, respectively. The FC of ACC before and after acupuncture was compared with paired t-test and the detailed results are presented in the paper. Our results showed that effects of the acupuncture on FC were closely related to clinical duration in patients with BP, which suggested that brain response to acupuncture was closely connected with the status of brain functional connectivity and implied that acupuncture plays a homeostatic role in the BP treatment.

No MeSH data available.


Related in: MedlinePlus

Changed functional connectivity of right ACC after acupuncture for patients with Bell's palsy at early stage. P ≤ 0.01, α ≤ 0.05, corrected with Monte-Carlo method. BA: Brodmann area; SFG: superior frontal gyrus; MFG: right middle frontal gyrus; MFG: middle frontal gyrus.
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fig3: Changed functional connectivity of right ACC after acupuncture for patients with Bell's palsy at early stage. P ≤ 0.01, α ≤ 0.05, corrected with Monte-Carlo method. BA: Brodmann area; SFG: superior frontal gyrus; MFG: right middle frontal gyrus; MFG: middle frontal gyrus.

Mentions: Different results were observed for the early group. In the early group, after being corrected with Monte-Carlo method (P = 0.01, α = 0.05, and cluster size = 68), significant changed FC were found after acupuncture. For the left ACC (ipsilateral to Bell's palsy), no remarkable changes of FC were found. Significant decreased connectivity of the right ACC (contralateral to BP) after acupuncture were observed in right superior frontal gyrus (SFG, BA 8), right middle frontal gyrus (MFG, BA 6), and right middle frontal gyrus (MFG, BA 10) (as shown in Figure 3 and Table 1).


Effect of Acupuncture on Functional Connectivity of Anterior Cingulate Cortex for Bell's Palsy Patients with Different Clinical Duration.

Wu H, Kan H, Li C, Park K, Zhu Y, Mohamed AZ, Xu C, Wu Y, Zhang W, Yang J - Evid Based Complement Alternat Med (2015)

Changed functional connectivity of right ACC after acupuncture for patients with Bell's palsy at early stage. P ≤ 0.01, α ≤ 0.05, corrected with Monte-Carlo method. BA: Brodmann area; SFG: superior frontal gyrus; MFG: right middle frontal gyrus; MFG: middle frontal gyrus.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4487273&req=5

fig3: Changed functional connectivity of right ACC after acupuncture for patients with Bell's palsy at early stage. P ≤ 0.01, α ≤ 0.05, corrected with Monte-Carlo method. BA: Brodmann area; SFG: superior frontal gyrus; MFG: right middle frontal gyrus; MFG: middle frontal gyrus.
Mentions: Different results were observed for the early group. In the early group, after being corrected with Monte-Carlo method (P = 0.01, α = 0.05, and cluster size = 68), significant changed FC were found after acupuncture. For the left ACC (ipsilateral to Bell's palsy), no remarkable changes of FC were found. Significant decreased connectivity of the right ACC (contralateral to BP) after acupuncture were observed in right superior frontal gyrus (SFG, BA 8), right middle frontal gyrus (MFG, BA 6), and right middle frontal gyrus (MFG, BA 10) (as shown in Figure 3 and Table 1).

Bottom Line: In order to explore the potential mechanism, changes of functional connectivity (FC) of anterior cingulate gyrus (ACC) were investigated.We collected 20 healthy (control group) participants and 28 BP patients with different clinical duration accepted resting state functional MRI (rfMRI) scans before and after acupuncture, respectively.The FC of ACC before and after acupuncture was compared with paired t-test and the detailed results are presented in the paper.

View Article: PubMed Central - PubMed

Affiliation: Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China ; Laboratory of Digital Medical Imaging, Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China.

ABSTRACT
Acupuncture is widely used in the treatment of Bell's palsy (BP) in many countries, but its underlying physiological mechanism remained controversial. In order to explore the potential mechanism, changes of functional connectivity (FC) of anterior cingulate gyrus (ACC) were investigated. We collected 20 healthy (control group) participants and 28 BP patients with different clinical duration accepted resting state functional MRI (rfMRI) scans before and after acupuncture, respectively. The FC of ACC before and after acupuncture was compared with paired t-test and the detailed results are presented in the paper. Our results showed that effects of the acupuncture on FC were closely related to clinical duration in patients with BP, which suggested that brain response to acupuncture was closely connected with the status of brain functional connectivity and implied that acupuncture plays a homeostatic role in the BP treatment.

No MeSH data available.


Related in: MedlinePlus