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Understanding Heterogeneity and Permeability of Brain Metastases in Murine Models of HER2-Positive Breast Cancer Through Magnetic Resonance Imaging: Implications for Detection and Therapy.

Murrell DH, Hamilton AM, Mallett CL, van Gorkum R, Chambers AF, Foster PJ - Transl Oncol (2015)

Bottom Line: The mean volume of an MDA-MB-231-BR-HER2 tumor was significantly larger compared to other models (F2,12 = 5.845, P < .05); interestingly, this model also had a significantly higher proportion of Gd-impermeable tumors (F2,12 = 22.18, P < .0001).Ki67 staining indicated that Gd-impermeable tumors had significantly more proliferative nuclei compared to Gd-permeable tumors (t[24] = 2.389, P < .05) in the MDA-MB-231-BR-HER2 model.Understanding this heterogeneity, especially as it relates to BBB permeability, is important for improvement in brain metastasis detection and treatment delivery.

View Article: PubMed Central - PubMed

Affiliation: Imaging, Robarts Research Institute, London, Ontario, Canada; Medical Biophysics, Western University, London, Ontario, Canada. Electronic address: dmurrell@robarts.ca.

No MeSH data available.


Related in: MedlinePlus

Quantification of the mean percentage of Gd-permeable (black) and Gd-permeable (white) tumors (± SEM). The percentage of Gd-permeable or Gd-impermeable tumors was significantly different between groups (F2,12 = 22.18, P < .0001). All SUM190-BR3 and most JIMT-1-BR3 tumors were Gd permeable, whereas only 63.6% of MDA-MB-231-BR-HER2 tumors display BTB permeability to Gd. Post hoc Tukey tests showed that the MDA-MB-231-BR-HER2 had a significantly different proportion of Gd-permeable and Gd-impermeable tumors compared to the JIMT-1-BR3 or SUM190-BR3 models. No other significant differences in permeability were observed.
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f0015: Quantification of the mean percentage of Gd-permeable (black) and Gd-permeable (white) tumors (± SEM). The percentage of Gd-permeable or Gd-impermeable tumors was significantly different between groups (F2,12 = 22.18, P < .0001). All SUM190-BR3 and most JIMT-1-BR3 tumors were Gd permeable, whereas only 63.6% of MDA-MB-231-BR-HER2 tumors display BTB permeability to Gd. Post hoc Tukey tests showed that the MDA-MB-231-BR-HER2 had a significantly different proportion of Gd-permeable and Gd-impermeable tumors compared to the JIMT-1-BR3 or SUM190-BR3 models. No other significant differences in permeability were observed.

Mentions: The tumor permeability status for the three models is shown in Figure 3. A significant difference was observed in the percentage of Gd-permeable or Gd-impermeable tumors between models (F2,12 = 22.18, P < .0001). Post hoc Tukey tests showed the MDA-MB-231-BR-HER2 had a significantly different proportion of Gd-permeable and Gd-impermeable tumors compared to the JIMT-1-BR3 or SUM190-BR3 models. All of the SUM-190-BR3 tumors and most JIMT-1-BR3 tumors were Gd permeable, whereas only 63.6% of the MDA-MB-231-BR-HER2 tumors displayed BTB permeability to Gd. T1w SE post-Gd MR failed to detect 36.4% of MDA-MB-231-BR-HER2 metastases that were visible in bSSFP images. No other significant differences within or between groups were observed.


Understanding Heterogeneity and Permeability of Brain Metastases in Murine Models of HER2-Positive Breast Cancer Through Magnetic Resonance Imaging: Implications for Detection and Therapy.

Murrell DH, Hamilton AM, Mallett CL, van Gorkum R, Chambers AF, Foster PJ - Transl Oncol (2015)

Quantification of the mean percentage of Gd-permeable (black) and Gd-permeable (white) tumors (± SEM). The percentage of Gd-permeable or Gd-impermeable tumors was significantly different between groups (F2,12 = 22.18, P < .0001). All SUM190-BR3 and most JIMT-1-BR3 tumors were Gd permeable, whereas only 63.6% of MDA-MB-231-BR-HER2 tumors display BTB permeability to Gd. Post hoc Tukey tests showed that the MDA-MB-231-BR-HER2 had a significantly different proportion of Gd-permeable and Gd-impermeable tumors compared to the JIMT-1-BR3 or SUM190-BR3 models. No other significant differences in permeability were observed.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4487267&req=5

f0015: Quantification of the mean percentage of Gd-permeable (black) and Gd-permeable (white) tumors (± SEM). The percentage of Gd-permeable or Gd-impermeable tumors was significantly different between groups (F2,12 = 22.18, P < .0001). All SUM190-BR3 and most JIMT-1-BR3 tumors were Gd permeable, whereas only 63.6% of MDA-MB-231-BR-HER2 tumors display BTB permeability to Gd. Post hoc Tukey tests showed that the MDA-MB-231-BR-HER2 had a significantly different proportion of Gd-permeable and Gd-impermeable tumors compared to the JIMT-1-BR3 or SUM190-BR3 models. No other significant differences in permeability were observed.
Mentions: The tumor permeability status for the three models is shown in Figure 3. A significant difference was observed in the percentage of Gd-permeable or Gd-impermeable tumors between models (F2,12 = 22.18, P < .0001). Post hoc Tukey tests showed the MDA-MB-231-BR-HER2 had a significantly different proportion of Gd-permeable and Gd-impermeable tumors compared to the JIMT-1-BR3 or SUM190-BR3 models. All of the SUM-190-BR3 tumors and most JIMT-1-BR3 tumors were Gd permeable, whereas only 63.6% of the MDA-MB-231-BR-HER2 tumors displayed BTB permeability to Gd. T1w SE post-Gd MR failed to detect 36.4% of MDA-MB-231-BR-HER2 metastases that were visible in bSSFP images. No other significant differences within or between groups were observed.

Bottom Line: The mean volume of an MDA-MB-231-BR-HER2 tumor was significantly larger compared to other models (F2,12 = 5.845, P < .05); interestingly, this model also had a significantly higher proportion of Gd-impermeable tumors (F2,12 = 22.18, P < .0001).Ki67 staining indicated that Gd-impermeable tumors had significantly more proliferative nuclei compared to Gd-permeable tumors (t[24] = 2.389, P < .05) in the MDA-MB-231-BR-HER2 model.Understanding this heterogeneity, especially as it relates to BBB permeability, is important for improvement in brain metastasis detection and treatment delivery.

View Article: PubMed Central - PubMed

Affiliation: Imaging, Robarts Research Institute, London, Ontario, Canada; Medical Biophysics, Western University, London, Ontario, Canada. Electronic address: dmurrell@robarts.ca.

No MeSH data available.


Related in: MedlinePlus