Limits...
A systematic analysis of human lipocalin family and its expression in esophageal carcinoma.

Du ZP, Wu BL, Wu X, Lin XH, Qiu XY, Zhan XF, Wang SH, Shen JH, Zheng CP, Wu ZY, Xu LY, Wang D, Li EM - Sci Rep (2015)

Bottom Line: Lipocalins have been found to play important roles in many human diseases.In this study, human lipocalins were found to contain four structurally conserved regions (SCRs) and could be divided into two subgroups.Their subcellular distributions also suggested these lipocalins may transfer signals from the extracellular space to the nucleus using the pathway-like paths.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China.

ABSTRACT
The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been found to play important roles in many human diseases. For this reason, a systemic analysis of the molecular properties of human lipocalins is essential. In this study, human lipocalins were found to contain four structurally conserved regions (SCRs) and could be divided into two subgroups. A human lipocalin protein-protein interaction network (PPIN) was constructed and integrated with their expression data in esophageal carcinoma. Many lipocalins showed obvious co-expression patterns in esophageal carcinoma. Their subcellular distributions also suggested these lipocalins may transfer signals from the extracellular space to the nucleus using the pathway-like paths. These analyses also expanded our knowledge about this human ancient protein family in the background of esophageal carcinoma.

No MeSH data available.


Related in: MedlinePlus

(A) Subcellular layers illustrating the lipocalins PPIN. (B) 20 possible paths from LCN2 to RB1 with integrated with their subcellular localization.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4487233&req=5

f5: (A) Subcellular layers illustrating the lipocalins PPIN. (B) 20 possible paths from LCN2 to RB1 with integrated with their subcellular localization.

Mentions: The appropriate subcellular localization and translocations of proteins are crucial to their functionality. Their functions include complex formation, signal transduction, protein modification, and disease28. In a network, nodes were re-distributed by Cerebral plugin according to their subcellular localization without changing their interactions. The lipocalin PPIN was here divided into 7 layers: secreted, membrane, cytoplasm, secreted/nucleus, membrane/nucleus, cytoplasm/nucleus, and nucleus (Fig. 5A). These results suggest that lipocalins can transfer cell signals of themselves or their binding complexes from the extracellular space to the intracellular space and nucleus, possibly through the noncanonical pathways.


A systematic analysis of human lipocalin family and its expression in esophageal carcinoma.

Du ZP, Wu BL, Wu X, Lin XH, Qiu XY, Zhan XF, Wang SH, Shen JH, Zheng CP, Wu ZY, Xu LY, Wang D, Li EM - Sci Rep (2015)

(A) Subcellular layers illustrating the lipocalins PPIN. (B) 20 possible paths from LCN2 to RB1 with integrated with their subcellular localization.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4487233&req=5

f5: (A) Subcellular layers illustrating the lipocalins PPIN. (B) 20 possible paths from LCN2 to RB1 with integrated with their subcellular localization.
Mentions: The appropriate subcellular localization and translocations of proteins are crucial to their functionality. Their functions include complex formation, signal transduction, protein modification, and disease28. In a network, nodes were re-distributed by Cerebral plugin according to their subcellular localization without changing their interactions. The lipocalin PPIN was here divided into 7 layers: secreted, membrane, cytoplasm, secreted/nucleus, membrane/nucleus, cytoplasm/nucleus, and nucleus (Fig. 5A). These results suggest that lipocalins can transfer cell signals of themselves or their binding complexes from the extracellular space to the intracellular space and nucleus, possibly through the noncanonical pathways.

Bottom Line: Lipocalins have been found to play important roles in many human diseases.In this study, human lipocalins were found to contain four structurally conserved regions (SCRs) and could be divided into two subgroups.Their subcellular distributions also suggested these lipocalins may transfer signals from the extracellular space to the nucleus using the pathway-like paths.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China.

ABSTRACT
The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been found to play important roles in many human diseases. For this reason, a systemic analysis of the molecular properties of human lipocalins is essential. In this study, human lipocalins were found to contain four structurally conserved regions (SCRs) and could be divided into two subgroups. A human lipocalin protein-protein interaction network (PPIN) was constructed and integrated with their expression data in esophageal carcinoma. Many lipocalins showed obvious co-expression patterns in esophageal carcinoma. Their subcellular distributions also suggested these lipocalins may transfer signals from the extracellular space to the nucleus using the pathway-like paths. These analyses also expanded our knowledge about this human ancient protein family in the background of esophageal carcinoma.

No MeSH data available.


Related in: MedlinePlus