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Extrahepatic metastases as initial manifestations of hepatocellular carcinoma: an Egyptian experience.

Helal Tel A, Radwan NA, Shaker M - Diagn Pathol (2015)

Bottom Line: The patients included in the study were 38 males and 9 females, ranging from 40 to 80 years (median 60 years).All patients were HCV-positive and 36 were cirrhotic.The diagnosis of primary HCC was confirmed in all cases, based on the typical hypervascular radiological features and/or high serum α-fetoprotein concentration, or histologic examination of liver biopsy.

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Faculty of Medicine, Ain Shams University, Ramses Street- New Faculty Bldg. -5th floor, P.O. # 11566, Cairo, Egypt. Thanaahelal2@hotmail.com.

ABSTRACT

Background: The incidence of hepatocellular carcinoma (HCC) in Egypt has markedly increased in the recent years, mainly due to the high incidence of hepatitis C virus (HCV) infection. Consequently, the frequency of metastatic HCC has also increased. The current study presents a series of 47 patients who were initially diagnosed as metastatic HCC.

Methods: Forty seven patients with the diagnosis of extrahepatic metastases of HCC at initial presentation were included in the study. The sites of metastases were bones (17), lymph nodes (9), soft tissue (7), omentum (7), maxillary sinus (2), adrenal gland (2), brain (2) and skin (1). The diagnosis of metastatic HCC was confirmed by immunohistochemistry.

Results: The patients included in the study were 38 males and 9 females, ranging from 40 to 80 years (median 60 years). All patients were HCV-positive and 36 were cirrhotic. The diagnosis of primary HCC was confirmed in all cases, based on the typical hypervascular radiological features and/or high serum α-fetoprotein concentration, or histologic examination of liver biopsy.

Conclusion: Metastasis of HCC should be put into consideration when evaluating metastatic carcinoma with unknown primary. This is of particular importance in the Egyptian population who has the highest prevalence of HCV infection in the world.

No MeSH data available.


Related in: MedlinePlus

A case of metastatic hepatocellular carcinoma. Note the trabecular pattern of growth with pleomorphic, hyperchromatic nuclei; (H&E, original magnification × 400)
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Fig2: A case of metastatic hepatocellular carcinoma. Note the trabecular pattern of growth with pleomorphic, hyperchromatic nuclei; (H&E, original magnification × 400)

Mentions: Histology: All metastatic lesions showed malignant tumor tissue which consists of large hepatocyte-like cells with moderate nuclear atypia and prominent mitotic activity. The cells are mostly arranged in trabecular or sinusoidal pattern, which is very reminiscent to that seen in primary HCC (Fig. 2). So, the histologic diagnosis was metastatic carcinoma of possible hepatocellular origin.


Extrahepatic metastases as initial manifestations of hepatocellular carcinoma: an Egyptian experience.

Helal Tel A, Radwan NA, Shaker M - Diagn Pathol (2015)

A case of metastatic hepatocellular carcinoma. Note the trabecular pattern of growth with pleomorphic, hyperchromatic nuclei; (H&E, original magnification × 400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4487213&req=5

Fig2: A case of metastatic hepatocellular carcinoma. Note the trabecular pattern of growth with pleomorphic, hyperchromatic nuclei; (H&E, original magnification × 400)
Mentions: Histology: All metastatic lesions showed malignant tumor tissue which consists of large hepatocyte-like cells with moderate nuclear atypia and prominent mitotic activity. The cells are mostly arranged in trabecular or sinusoidal pattern, which is very reminiscent to that seen in primary HCC (Fig. 2). So, the histologic diagnosis was metastatic carcinoma of possible hepatocellular origin.

Bottom Line: The patients included in the study were 38 males and 9 females, ranging from 40 to 80 years (median 60 years).All patients were HCV-positive and 36 were cirrhotic.The diagnosis of primary HCC was confirmed in all cases, based on the typical hypervascular radiological features and/or high serum α-fetoprotein concentration, or histologic examination of liver biopsy.

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Faculty of Medicine, Ain Shams University, Ramses Street- New Faculty Bldg. -5th floor, P.O. # 11566, Cairo, Egypt. Thanaahelal2@hotmail.com.

ABSTRACT

Background: The incidence of hepatocellular carcinoma (HCC) in Egypt has markedly increased in the recent years, mainly due to the high incidence of hepatitis C virus (HCV) infection. Consequently, the frequency of metastatic HCC has also increased. The current study presents a series of 47 patients who were initially diagnosed as metastatic HCC.

Methods: Forty seven patients with the diagnosis of extrahepatic metastases of HCC at initial presentation were included in the study. The sites of metastases were bones (17), lymph nodes (9), soft tissue (7), omentum (7), maxillary sinus (2), adrenal gland (2), brain (2) and skin (1). The diagnosis of metastatic HCC was confirmed by immunohistochemistry.

Results: The patients included in the study were 38 males and 9 females, ranging from 40 to 80 years (median 60 years). All patients were HCV-positive and 36 were cirrhotic. The diagnosis of primary HCC was confirmed in all cases, based on the typical hypervascular radiological features and/or high serum α-fetoprotein concentration, or histologic examination of liver biopsy.

Conclusion: Metastasis of HCC should be put into consideration when evaluating metastatic carcinoma with unknown primary. This is of particular importance in the Egyptian population who has the highest prevalence of HCV infection in the world.

No MeSH data available.


Related in: MedlinePlus