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Evaluation of the Effect of Modafinil on Cognitive Functions in Patients with Idiopathic Hypersomnia with P300.

Yaman M, Karakaya F, Aydin T, Mayda H, Güzel Hİ, Kayaalp D - Med. Sci. Monit. (2015)

Bottom Line: After 1 week of modafinil treatment, mean P300 latencies (at all electrode sites) were significantly lower than the latencies before the treatment (P values for Fz, Cz and Pz recording sites were 0.039, 0.002, and 0.004, respectively).One week of modafinil treatment improved the cognitive performance, alertness, and executive functions in IH patients.Our electrophysiologically obtained findings provide further confirmation for previous reports in which modafinil has been shown to exert favorable effects on cognitive performance, alertness, and executive functions.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Afyon Kocatepe, Faculty of Medicine, Afyonkarahisar, Turkey.

ABSTRACT

Background: Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy and other excessive sleepiness. Whereas favorable effects of modafinil on cognitive functions have been shown in a large number of studies, there are very few reports presenting the effects of modafinil electrophysiologically. The aim of this study was to investigate the effects of modafinil on auditory P300 latency and amplitude electrophysiologically.

Material and methods: Eighteen patients (age range: 16-48 years) with a diagnosis of idiopathic hypersomnia (IH) were included in the present study. As a standard treatment, 200 mg/day modafinil was administered to each patient. The P300 auditory test was performed for each patient before and at the end of 1 week of modafinil treatment.

Results: After 1 week of modafinil treatment, mean P300 latencies (at all electrode sites) were significantly lower than the latencies before the treatment (P values for Fz, Cz and Pz recording sites were 0.039, 0.002, and 0.004, respectively). An increase in the P300 amplitudes was detected only at the Fz recording site, but not at Cz or Pz recording sites (P values for Fz, Cz, and Pz recording sites were 0.014, 0.100, and 0.05, respectively).

Conclusions: One week of modafinil treatment improved the cognitive performance, alertness, and executive functions in IH patients. Our electrophysiologically obtained findings provide further confirmation for previous reports in which modafinil has been shown to exert favorable effects on cognitive performance, alertness, and executive functions.

No MeSH data available.


Related in: MedlinePlus

Samples of auditory P300 for before (A) and after (B) modafinil treatment.
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f1-medscimonit-21-1850: Samples of auditory P300 for before (A) and after (B) modafinil treatment.

Mentions: In total, 18 patients were evaluated in the study (8 males, 10 females). Mean age was 23.0±6.7 (min: 16, max: 48). The grand means of the auditory P300 at all electrode sites for the 2 timepoints (before and after treatment) are presented in Figure 1. The latencies of the P300 component measured at the Fz, Cz, and Pz electrode sites were assessed separately. After 1 week of modafinil treatment, mean P300 latencies (at all electrode sites) had decreased significantly compared to latencies before the treatment (P values 0.039, 0.002, and 0.004, respectively, Table 1). After 1 week of modafinil treatment but mean P300 amplitudes were increased. A significant increase at the Fz electrode was detected after 1 week of modafinil treatment but mean P300 amplitudes were decreased and a significant increase at the Fz electrode was detected (Fz: 0.014, Cz: 0.100 and Pz: 0.05, Table 1).


Evaluation of the Effect of Modafinil on Cognitive Functions in Patients with Idiopathic Hypersomnia with P300.

Yaman M, Karakaya F, Aydin T, Mayda H, Güzel Hİ, Kayaalp D - Med. Sci. Monit. (2015)

Samples of auditory P300 for before (A) and after (B) modafinil treatment.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4487186&req=5

f1-medscimonit-21-1850: Samples of auditory P300 for before (A) and after (B) modafinil treatment.
Mentions: In total, 18 patients were evaluated in the study (8 males, 10 females). Mean age was 23.0±6.7 (min: 16, max: 48). The grand means of the auditory P300 at all electrode sites for the 2 timepoints (before and after treatment) are presented in Figure 1. The latencies of the P300 component measured at the Fz, Cz, and Pz electrode sites were assessed separately. After 1 week of modafinil treatment, mean P300 latencies (at all electrode sites) had decreased significantly compared to latencies before the treatment (P values 0.039, 0.002, and 0.004, respectively, Table 1). After 1 week of modafinil treatment but mean P300 amplitudes were increased. A significant increase at the Fz electrode was detected after 1 week of modafinil treatment but mean P300 amplitudes were decreased and a significant increase at the Fz electrode was detected (Fz: 0.014, Cz: 0.100 and Pz: 0.05, Table 1).

Bottom Line: After 1 week of modafinil treatment, mean P300 latencies (at all electrode sites) were significantly lower than the latencies before the treatment (P values for Fz, Cz and Pz recording sites were 0.039, 0.002, and 0.004, respectively).One week of modafinil treatment improved the cognitive performance, alertness, and executive functions in IH patients.Our electrophysiologically obtained findings provide further confirmation for previous reports in which modafinil has been shown to exert favorable effects on cognitive performance, alertness, and executive functions.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Afyon Kocatepe, Faculty of Medicine, Afyonkarahisar, Turkey.

ABSTRACT

Background: Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy and other excessive sleepiness. Whereas favorable effects of modafinil on cognitive functions have been shown in a large number of studies, there are very few reports presenting the effects of modafinil electrophysiologically. The aim of this study was to investigate the effects of modafinil on auditory P300 latency and amplitude electrophysiologically.

Material and methods: Eighteen patients (age range: 16-48 years) with a diagnosis of idiopathic hypersomnia (IH) were included in the present study. As a standard treatment, 200 mg/day modafinil was administered to each patient. The P300 auditory test was performed for each patient before and at the end of 1 week of modafinil treatment.

Results: After 1 week of modafinil treatment, mean P300 latencies (at all electrode sites) were significantly lower than the latencies before the treatment (P values for Fz, Cz and Pz recording sites were 0.039, 0.002, and 0.004, respectively). An increase in the P300 amplitudes was detected only at the Fz recording site, but not at Cz or Pz recording sites (P values for Fz, Cz, and Pz recording sites were 0.014, 0.100, and 0.05, respectively).

Conclusions: One week of modafinil treatment improved the cognitive performance, alertness, and executive functions in IH patients. Our electrophysiologically obtained findings provide further confirmation for previous reports in which modafinil has been shown to exert favorable effects on cognitive performance, alertness, and executive functions.

No MeSH data available.


Related in: MedlinePlus