Limits...
Genetic/molecular alterations of meningiomas and the signaling pathways targeted.

Domingues P, González-Tablas M, Otero Á, Pascual D, Ruiz L, Miranda D, Sousa P, Gonçalves JM, Lopes MC, Orfao A, Tabernero MD - Oncotarget (2015)

Bottom Line: Meningiomas are usually considered to be benign central nervous system tumors; however, they show heterogenous clinical, histolopathological and cytogenetic features associated with a variable outcome.Thus, monosomy 22, which is often associated with mutations of the NF2 gene, has emerged as the most frequent alteration of meningiomas; in addition, several other genes (e.g., AKT1, KLF4, TRAF7, SMO) and chromosomes have been found to be recurrently altered often in association with more complex karyotypes and involvement of multiple signaling pathways.Here we review the current knowledge about the most relevant genes involved and the signaling pathways targeted by such alterations.

View Article: PubMed Central - PubMed

Affiliation: Centre for Neurosciences and Cell Biology and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

ABSTRACT
Meningiomas are usually considered to be benign central nervous system tumors; however, they show heterogenous clinical, histolopathological and cytogenetic features associated with a variable outcome. In recent years important advances have been achieved in the identification of the genetic/molecular alterations of meningiomas and the signaling pathways involved. Thus, monosomy 22, which is often associated with mutations of the NF2 gene, has emerged as the most frequent alteration of meningiomas; in addition, several other genes (e.g., AKT1, KLF4, TRAF7, SMO) and chromosomes have been found to be recurrently altered often in association with more complex karyotypes and involvement of multiple signaling pathways. Here we review the current knowledge about the most relevant genes involved and the signaling pathways targeted by such alterations. In addition, we summarize those proposals that have been made so far for classification and prognostic stratification of meningiomas based on their genetic/genomic features.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram illustrating the key elements of some of the most relevant signaling pathways involved in the pathogenesis of meningiomasThe Ras-Raf-MEK-MAPK/ERK, PI3K-Akt/PKB, PLCγ1-PKC, PLA2-COX, JAK-STAT3 and mTOR signaling pathways are represented in the upper part of the scheme, while the relationships between the pRb and p53 cell cycle associated signaling pathways are illustrated in the lower part of the scheme. The pathway scheme displayed was generated with the Ingenuity Pathway Analysis (IPA) software (Ingenuity Systems Inc., Redwood City, CA, USA).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4484411&req=5

Figure 1: Schematic diagram illustrating the key elements of some of the most relevant signaling pathways involved in the pathogenesis of meningiomasThe Ras-Raf-MEK-MAPK/ERK, PI3K-Akt/PKB, PLCγ1-PKC, PLA2-COX, JAK-STAT3 and mTOR signaling pathways are represented in the upper part of the scheme, while the relationships between the pRb and p53 cell cycle associated signaling pathways are illustrated in the lower part of the scheme. The pathway scheme displayed was generated with the Ingenuity Pathway Analysis (IPA) software (Ingenuity Systems Inc., Redwood City, CA, USA).

Mentions: At present, it is well known that most of the above described genetic alterations have an impact on one or more signaling pathways which are recurrently involved in cancer. The most relevant and frequently altered signaling pathways in meningioma are reviewed in this next section and illustrated in Figure 1.


Genetic/molecular alterations of meningiomas and the signaling pathways targeted.

Domingues P, González-Tablas M, Otero Á, Pascual D, Ruiz L, Miranda D, Sousa P, Gonçalves JM, Lopes MC, Orfao A, Tabernero MD - Oncotarget (2015)

Schematic diagram illustrating the key elements of some of the most relevant signaling pathways involved in the pathogenesis of meningiomasThe Ras-Raf-MEK-MAPK/ERK, PI3K-Akt/PKB, PLCγ1-PKC, PLA2-COX, JAK-STAT3 and mTOR signaling pathways are represented in the upper part of the scheme, while the relationships between the pRb and p53 cell cycle associated signaling pathways are illustrated in the lower part of the scheme. The pathway scheme displayed was generated with the Ingenuity Pathway Analysis (IPA) software (Ingenuity Systems Inc., Redwood City, CA, USA).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4484411&req=5

Figure 1: Schematic diagram illustrating the key elements of some of the most relevant signaling pathways involved in the pathogenesis of meningiomasThe Ras-Raf-MEK-MAPK/ERK, PI3K-Akt/PKB, PLCγ1-PKC, PLA2-COX, JAK-STAT3 and mTOR signaling pathways are represented in the upper part of the scheme, while the relationships between the pRb and p53 cell cycle associated signaling pathways are illustrated in the lower part of the scheme. The pathway scheme displayed was generated with the Ingenuity Pathway Analysis (IPA) software (Ingenuity Systems Inc., Redwood City, CA, USA).
Mentions: At present, it is well known that most of the above described genetic alterations have an impact on one or more signaling pathways which are recurrently involved in cancer. The most relevant and frequently altered signaling pathways in meningioma are reviewed in this next section and illustrated in Figure 1.

Bottom Line: Meningiomas are usually considered to be benign central nervous system tumors; however, they show heterogenous clinical, histolopathological and cytogenetic features associated with a variable outcome.Thus, monosomy 22, which is often associated with mutations of the NF2 gene, has emerged as the most frequent alteration of meningiomas; in addition, several other genes (e.g., AKT1, KLF4, TRAF7, SMO) and chromosomes have been found to be recurrently altered often in association with more complex karyotypes and involvement of multiple signaling pathways.Here we review the current knowledge about the most relevant genes involved and the signaling pathways targeted by such alterations.

View Article: PubMed Central - PubMed

Affiliation: Centre for Neurosciences and Cell Biology and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

ABSTRACT
Meningiomas are usually considered to be benign central nervous system tumors; however, they show heterogenous clinical, histolopathological and cytogenetic features associated with a variable outcome. In recent years important advances have been achieved in the identification of the genetic/molecular alterations of meningiomas and the signaling pathways involved. Thus, monosomy 22, which is often associated with mutations of the NF2 gene, has emerged as the most frequent alteration of meningiomas; in addition, several other genes (e.g., AKT1, KLF4, TRAF7, SMO) and chromosomes have been found to be recurrently altered often in association with more complex karyotypes and involvement of multiple signaling pathways. Here we review the current knowledge about the most relevant genes involved and the signaling pathways targeted by such alterations. In addition, we summarize those proposals that have been made so far for classification and prognostic stratification of meningiomas based on their genetic/genomic features.

No MeSH data available.


Related in: MedlinePlus