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Low-Molecular-Weight Metabolites from Diatoms: Structures, Biological Roles and Biosynthesis.

Stonik V, Stonik I - Mar Drugs (2015)

Bottom Line: These microalgae are rich in various lipids, carotenoids, sterols and isoprenoids, some of them containing toxins and other metabolites.However, chemical studies on these microalgae are complicated by difficulties, connected with obtaining their biomass, and the influence of nutrients and contaminators in their environment as well as by seasonal and climatic factors on the biosynthesis of the corresponding natural products.Overall, the number of chemically studied diatoms is lower than that of other algae, but further studies, particularly those connected with improvements in the isolation and structure elucidation technique as well as the genomics of diatoms, promise both to increase the number of studied species with isolated biologically active natural products and to provide a clearer perception of their biosynthesis.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Chemistry of Marine Natural Products, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok 690022, Russia. stonik@piboc.dvo.ru.

ABSTRACT
Diatoms are abundant and important biological components of the marine environment that biosynthesize diverse natural products. These microalgae are rich in various lipids, carotenoids, sterols and isoprenoids, some of them containing toxins and other metabolites. Several groups of diatom natural products have attracted great interest due to their potential practical application as energy sources (biofuel), valuable food constituents, and prospective materials for nanotechnology. In addition, hydrocarbons, which are used in climate reconstruction, polyamines which participate in biomineralization, new apoptotic agents against tumor cells, attractants and deterrents that regulate the biochemical communications between marine species in seawaters have also been isolated from diatoms. However, chemical studies on these microalgae are complicated by difficulties, connected with obtaining their biomass, and the influence of nutrients and contaminators in their environment as well as by seasonal and climatic factors on the biosynthesis of the corresponding natural products. Overall, the number of chemically studied diatoms is lower than that of other algae, but further studies, particularly those connected with improvements in the isolation and structure elucidation technique as well as the genomics of diatoms, promise both to increase the number of studied species with isolated biologically active natural products and to provide a clearer perception of their biosynthesis.

No MeSH data available.


Related in: MedlinePlus

Transformation of eicopentaenic acid into a mixture of chlorinated C8 hydrocarbons in the marine diatom Stephanopyxis turris [113].
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marinedrugs-13-03672-f018: Transformation of eicopentaenic acid into a mixture of chlorinated C8 hydrocarbons in the marine diatom Stephanopyxis turris [113].

Mentions: Some products of lipoxygenase biosynthesis also contain halogen atoms. A transformation of eicosapentaenoic acid into a mixture of chlorinated C8 hydrocarbons is initiated upon disintegration of the marine diatom Stephanopyxis turris. Another product of this transformation was identified as 12-oxo acid* (Figure 18). This is the result of the action of a lipoxygenase followed by a cleavage of the intermediate hydroperoxide by a hydroperoxide halolyase [113].


Low-Molecular-Weight Metabolites from Diatoms: Structures, Biological Roles and Biosynthesis.

Stonik V, Stonik I - Mar Drugs (2015)

Transformation of eicopentaenic acid into a mixture of chlorinated C8 hydrocarbons in the marine diatom Stephanopyxis turris [113].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4483651&req=5

marinedrugs-13-03672-f018: Transformation of eicopentaenic acid into a mixture of chlorinated C8 hydrocarbons in the marine diatom Stephanopyxis turris [113].
Mentions: Some products of lipoxygenase biosynthesis also contain halogen atoms. A transformation of eicosapentaenoic acid into a mixture of chlorinated C8 hydrocarbons is initiated upon disintegration of the marine diatom Stephanopyxis turris. Another product of this transformation was identified as 12-oxo acid* (Figure 18). This is the result of the action of a lipoxygenase followed by a cleavage of the intermediate hydroperoxide by a hydroperoxide halolyase [113].

Bottom Line: These microalgae are rich in various lipids, carotenoids, sterols and isoprenoids, some of them containing toxins and other metabolites.However, chemical studies on these microalgae are complicated by difficulties, connected with obtaining their biomass, and the influence of nutrients and contaminators in their environment as well as by seasonal and climatic factors on the biosynthesis of the corresponding natural products.Overall, the number of chemically studied diatoms is lower than that of other algae, but further studies, particularly those connected with improvements in the isolation and structure elucidation technique as well as the genomics of diatoms, promise both to increase the number of studied species with isolated biologically active natural products and to provide a clearer perception of their biosynthesis.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Chemistry of Marine Natural Products, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok 690022, Russia. stonik@piboc.dvo.ru.

ABSTRACT
Diatoms are abundant and important biological components of the marine environment that biosynthesize diverse natural products. These microalgae are rich in various lipids, carotenoids, sterols and isoprenoids, some of them containing toxins and other metabolites. Several groups of diatom natural products have attracted great interest due to their potential practical application as energy sources (biofuel), valuable food constituents, and prospective materials for nanotechnology. In addition, hydrocarbons, which are used in climate reconstruction, polyamines which participate in biomineralization, new apoptotic agents against tumor cells, attractants and deterrents that regulate the biochemical communications between marine species in seawaters have also been isolated from diatoms. However, chemical studies on these microalgae are complicated by difficulties, connected with obtaining their biomass, and the influence of nutrients and contaminators in their environment as well as by seasonal and climatic factors on the biosynthesis of the corresponding natural products. Overall, the number of chemically studied diatoms is lower than that of other algae, but further studies, particularly those connected with improvements in the isolation and structure elucidation technique as well as the genomics of diatoms, promise both to increase the number of studied species with isolated biologically active natural products and to provide a clearer perception of their biosynthesis.

No MeSH data available.


Related in: MedlinePlus