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Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Related in: MedlinePlus

Structures of compound 96–101.
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marinedrugs-13-03479-f022: Structures of compound 96–101.

Mentions: Comazaphilones A–F (96–101) (Figure 22) were isolated from P. commune QSD-17. Comazaphilones C–E (98–100) displayed potent antibacterial activities against S. aureus MRSA, P. fluorescens and B.subtilis (MIC, 16, 64 and 32 μg/mL for 98; 32, 16 and more than 256 μg/mL for 99; and more than 256 μg/mL, 32 and 16 μg/mL for 100, respectively). The SAR results indicated that the double bond at C-10 of 98–100, as well as the location of the orsellinic acid unit at C-6 of 99 and 100 are important for their activity [77].


Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Structures of compound 96–101.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4483641&req=5

marinedrugs-13-03479-f022: Structures of compound 96–101.
Mentions: Comazaphilones A–F (96–101) (Figure 22) were isolated from P. commune QSD-17. Comazaphilones C–E (98–100) displayed potent antibacterial activities against S. aureus MRSA, P. fluorescens and B.subtilis (MIC, 16, 64 and 32 μg/mL for 98; 32, 16 and more than 256 μg/mL for 99; and more than 256 μg/mL, 32 and 16 μg/mL for 100, respectively). The SAR results indicated that the double bond at C-10 of 98–100, as well as the location of the orsellinic acid unit at C-6 of 99 and 100 are important for their activity [77].

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Related in: MedlinePlus