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Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Related in: MedlinePlus

Structures of compound 94–95 (the red moiety enhances the antimicrobial activity).
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marinedrugs-13-03479-f021: Structures of compound 94–95 (the red moiety enhances the antimicrobial activity).

Mentions: Aflatoxin B2b (94) (Figure 21) was isolated from A. flavus 092008 and exhibited moderate antimicrobial activity against E. coli, B. subtilis and E. aerogenes (MIC, 22.5, 1.7 and 1.1 µM, respectively) [74]. Compound 94 was elucidated to be the 4-methoxy-4-oxobutanoyl substitution for the acetyl group of 8-acetyloxyaflatoxin B1. By comparison to 8-acetyloxyaflatoxin B1, the 4-methoxy-4-oxobutanoyl moiety partly contributes to the antibacterial activity of 94. Moreover, based on aflatoxins B1 and aflatoxins B1, the acetyloxy group of 8-acetyloxyaflatoxin B1 is not related to the antibacterial activity. Isochromophilone XI (95) (Figure 21) was isolated from Bartalinia robillardoides LF550 and showed antibacterial and antifungal activities against B. subtilis, S. lentus and Trichophyton rubrum (MIC, 55.6, 78.4 and 41.5 μM, respectively). The oxygen in the pyran ring of 95 is important for its antibacterial and antifungal activities, as determined by comparison to inactive analogs of 95 [75,76].


Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Structures of compound 94–95 (the red moiety enhances the antimicrobial activity).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4483641&req=5

marinedrugs-13-03479-f021: Structures of compound 94–95 (the red moiety enhances the antimicrobial activity).
Mentions: Aflatoxin B2b (94) (Figure 21) was isolated from A. flavus 092008 and exhibited moderate antimicrobial activity against E. coli, B. subtilis and E. aerogenes (MIC, 22.5, 1.7 and 1.1 µM, respectively) [74]. Compound 94 was elucidated to be the 4-methoxy-4-oxobutanoyl substitution for the acetyl group of 8-acetyloxyaflatoxin B1. By comparison to 8-acetyloxyaflatoxin B1, the 4-methoxy-4-oxobutanoyl moiety partly contributes to the antibacterial activity of 94. Moreover, based on aflatoxins B1 and aflatoxins B1, the acetyloxy group of 8-acetyloxyaflatoxin B1 is not related to the antibacterial activity. Isochromophilone XI (95) (Figure 21) was isolated from Bartalinia robillardoides LF550 and showed antibacterial and antifungal activities against B. subtilis, S. lentus and Trichophyton rubrum (MIC, 55.6, 78.4 and 41.5 μM, respectively). The oxygen in the pyran ring of 95 is important for its antibacterial and antifungal activities, as determined by comparison to inactive analogs of 95 [75,76].

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Related in: MedlinePlus