Limits...
Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Related in: MedlinePlus

Structures of compound 85–89 (the red moiety enhances the antimicrobial activity).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4483641&req=5

marinedrugs-13-03479-f019: Structures of compound 85–89 (the red moiety enhances the antimicrobial activity).

Mentions: The structures of compound 85–89 were shown in Figure 19. Austalide R (85), M (86) and N (87) were isolated from Aspergillus sp. and exhibited antibacterial activity against Halomonas aquamarina, Polaribacter irgensii, Pseudoalteromonas elyakovii, Roseobacter litoralis, Shewanella putrefaciens, V. harveyi, V. natriegens, V. proteolyticus and V. carchariae (MIC, 0.01–0.1 μg/mL for 85; 0.001–0.01 μg/mL for 86 and 0.01 μg/mL for 87). The R1 substituents at C-17 and R2 at C-22 (shown in the structures of 85 and 86) significantly enhance their antibacterial activities [20,71]. Talaromycesone A (88) and B (89) were isolated from Talaromyces sp. LF458 and exhibited potent antibacterial activities against human pathogenic S. epidermidis (IC50, 3.70 and 17.36 μM, respectively) and S. aureus MRSA (IC50, 5.48 and 19.50 μM, respectively) [72].


Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Structures of compound 85–89 (the red moiety enhances the antimicrobial activity).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4483641&req=5

marinedrugs-13-03479-f019: Structures of compound 85–89 (the red moiety enhances the antimicrobial activity).
Mentions: The structures of compound 85–89 were shown in Figure 19. Austalide R (85), M (86) and N (87) were isolated from Aspergillus sp. and exhibited antibacterial activity against Halomonas aquamarina, Polaribacter irgensii, Pseudoalteromonas elyakovii, Roseobacter litoralis, Shewanella putrefaciens, V. harveyi, V. natriegens, V. proteolyticus and V. carchariae (MIC, 0.01–0.1 μg/mL for 85; 0.001–0.01 μg/mL for 86 and 0.01 μg/mL for 87). The R1 substituents at C-17 and R2 at C-22 (shown in the structures of 85 and 86) significantly enhance their antibacterial activities [20,71]. Talaromycesone A (88) and B (89) were isolated from Talaromyces sp. LF458 and exhibited potent antibacterial activities against human pathogenic S. epidermidis (IC50, 3.70 and 17.36 μM, respectively) and S. aureus MRSA (IC50, 5.48 and 19.50 μM, respectively) [72].

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Related in: MedlinePlus