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Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Related in: MedlinePlus

Structures of compound 62–65 (the red moiety enhances the antimicrobial activity).
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marinedrugs-13-03479-f015: Structures of compound 62–65 (the red moiety enhances the antimicrobial activity).

Mentions: The structures of compound 62–65 were shown in Figure 15. Anthraquinone derivatives, 62 and 63, were isolated from Nigrospora sp. No. 1403. Compound 62 exhibited potent activity against B. subtilis (MIC, 0.625), B. cereus (MIC, 10.0), M. luteus (MIC, 20.0 µM), S. albus (MIC, 5.00 µM), S. aureus (MIC, 2.50 µM), M. teragenus (MIC, 1.25 µM), E. coli (MIC, 2.50 µM), V. anguillarum (MIC, 2.50 µM) and V. parachemolyticus (MIC, 1.25 µM). Compound 63 was from the same fungal strain, but its antibacterial activity was significantly weaker than 62 [56]. From comparison of several known anthraquinone derivatives, the hydroxyl groups of 62 at C-4 and C-9 have little effect on the antibacterial activity but the hydroxyl group of 62 at C-3 most likely contributes to its antibacterial activity [56,57]. Seimatorone (64) was isolated from Seimatosporium sp. No. 8883 and showed antibacterial activity against E. coli and B. megaterium (IZ, 3 and 7 mm at 50 μg/disk, respectively) [58]. Trichodermaketone A (65) was from T. koningii and exhibited synergistic antifungal activity against C. albicans at 125 µg/mL with 0.05 µg/mL ketoconazole [59].


Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Structures of compound 62–65 (the red moiety enhances the antimicrobial activity).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4483641&req=5

marinedrugs-13-03479-f015: Structures of compound 62–65 (the red moiety enhances the antimicrobial activity).
Mentions: The structures of compound 62–65 were shown in Figure 15. Anthraquinone derivatives, 62 and 63, were isolated from Nigrospora sp. No. 1403. Compound 62 exhibited potent activity against B. subtilis (MIC, 0.625), B. cereus (MIC, 10.0), M. luteus (MIC, 20.0 µM), S. albus (MIC, 5.00 µM), S. aureus (MIC, 2.50 µM), M. teragenus (MIC, 1.25 µM), E. coli (MIC, 2.50 µM), V. anguillarum (MIC, 2.50 µM) and V. parachemolyticus (MIC, 1.25 µM). Compound 63 was from the same fungal strain, but its antibacterial activity was significantly weaker than 62 [56]. From comparison of several known anthraquinone derivatives, the hydroxyl groups of 62 at C-4 and C-9 have little effect on the antibacterial activity but the hydroxyl group of 62 at C-3 most likely contributes to its antibacterial activity [56,57]. Seimatorone (64) was isolated from Seimatosporium sp. No. 8883 and showed antibacterial activity against E. coli and B. megaterium (IZ, 3 and 7 mm at 50 μg/disk, respectively) [58]. Trichodermaketone A (65) was from T. koningii and exhibited synergistic antifungal activity against C. albicans at 125 µg/mL with 0.05 µg/mL ketoconazole [59].

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Related in: MedlinePlus