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Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.


Structures of compound 49–52.
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marinedrugs-13-03479-f012: Structures of compound 49–52.

Mentions: The structures of compound 49–52 were shown in Figure 12. Sesterterpene ophiobolin U (49) was isolated from fresh A. ustus cf-42 and exhibited inhibitory activities against E. coli and S. aureus (IZ, 15 and 10 mm at 30 μg/disk, respectively) [45]. Libertellenone G (50) was isolated from Eutypella sp. D-1 and showed antibacterial activity against E. coli, B. subtilis and S. aureus (IZ, 8, 8 and 9 at 50 μg/disk) [46]. Chevalone E (51) was isolated from A. similanensis sp. nov. KUFA 0013, which was found to show synergism with the antibiotic oxacillin against methicillin-resistant S. aureus (MRSA) [47]. Compound 52 was only produced by Nigrospora sp. MA75 in medium with 3.5% NaI and exhibited activity against MRSA (MIC, 8 µg/mL), E. coli (MIC, 4 μg/mL), P. aeruginosa (MIC, 4 µg/mL), P. fluorescens (MIC, 0.5 µg/mL) and S. epidermidis (MIC, 0.5 µg/mL), which implies that the added iodide ion may be triggering the activation of a mixed polyketide terpenoid biosynthetic pathway in this fungal strain [48].


Antibacterial and antifungal compounds from marine fungi.

Xu L, Meng W, Cao C, Wang J, Shan W, Wang Q - Mar Drugs (2015)

Structures of compound 49–52.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4483641&req=5

marinedrugs-13-03479-f012: Structures of compound 49–52.
Mentions: The structures of compound 49–52 were shown in Figure 12. Sesterterpene ophiobolin U (49) was isolated from fresh A. ustus cf-42 and exhibited inhibitory activities against E. coli and S. aureus (IZ, 15 and 10 mm at 30 μg/disk, respectively) [45]. Libertellenone G (50) was isolated from Eutypella sp. D-1 and showed antibacterial activity against E. coli, B. subtilis and S. aureus (IZ, 8, 8 and 9 at 50 μg/disk) [46]. Chevalone E (51) was isolated from A. similanensis sp. nov. KUFA 0013, which was found to show synergism with the antibiotic oxacillin against methicillin-resistant S. aureus (MRSA) [47]. Compound 52 was only produced by Nigrospora sp. MA75 in medium with 3.5% NaI and exhibited activity against MRSA (MIC, 8 µg/mL), E. coli (MIC, 4 μg/mL), P. aeruginosa (MIC, 4 µg/mL), P. fluorescens (MIC, 0.5 µg/mL) and S. epidermidis (MIC, 0.5 µg/mL), which implies that the added iodide ion may be triggering the activation of a mixed polyketide terpenoid biosynthetic pathway in this fungal strain [48].

Bottom Line: This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015.Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed.The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

View Article: PubMed Central - PubMed

Affiliation: College of Agricultural Resource and Environment, Heilongjiang University, Harbin 150080, China. xulijian@hlju.edu.cn.

ABSTRACT
This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

No MeSH data available.