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Characteristics of the Delayed or Refusal Therapy in Breast Cancer Patients: A Longitudinal Population-Based Study in Taiwan.

Chen SJ, Kung PT, Huang KH, Wang YH, Tsai WC - PLoS ONE (2015)

Bottom Line: The patients who delayed or refused therapy had lower 5-year overall survival rate compared with the treated group.Our results demonstrated that age and cancer staging were the main patient characteristics affecting whether the patients delayed or refused therapy.The delay or refusal of treatment was associated with the level of diagnosing hospital.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Services Administration, China Medical University, Taichung, Taiwan; Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan.

ABSTRACT

Background: The evidence indicated breast cancer was a cancer with high survival rate. However, there were still some breast cancer patients delaying or refusing therapy. So we conducted a cohort study to explore the relationship between characteristics of breast cancer patients and delay or refusal of therapy within four months after cancer diagnosed.

Methods: This was a retrospective national population-based study from 2004 to 2010 in Taiwan. This study included 35,095 patients with new diagnosis breast cancer from Taiwan Cancer Registry Database. Several analysis methods, including t test, Chi-square test, generalized estimating equations of logistic regression analysis, and Cox proportional hazards model, were performed to explore the characteristics of these patients and the relative risk of mortality with delay or refusal of therapy.

Results: Our study showed that the overall survival rates were significantly different (p <0.05) between the breast cancer patients who delayed or refused therapy and those with treatment. The patients who delayed or refused therapy had lower 5-year overall survival rate compared with the treated group. The related factors included age, Charlson comorbidity index, cancer staging (OR = 1.30-19.69; p <0.05), other catastrophic illnesses or injuries and the level of diagnostic hospitals. However, the patients with different income levels and degree of urbanization in living area were not statistically significant factors.

Conclusion: Our results demonstrated that age and cancer staging were the main patient characteristics affecting whether the patients delayed or refused therapy. The delay or refusal of treatment was associated with the level of diagnosing hospital.

No MeSH data available.


Related in: MedlinePlus

Survival curves between treated and delayed/untreated patients of breast cancer at different stages.
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pone.0131305.g002: Survival curves between treated and delayed/untreated patients of breast cancer at different stages.

Mentions: This study showed that there was significant difference (p <0.05) in overall survival between patients who delayed or refused therapy and those with treatment (Fig 1). The 5-year survival rate was 85% and 45% for patients with treatment and those who delayed or refused therapy, respectively. We also displayed the survival situation at different stages between treated patients and delayed/refused treatment patients in Fig 2. The survival difference between two groups was more significant at stage II and stage III.


Characteristics of the Delayed or Refusal Therapy in Breast Cancer Patients: A Longitudinal Population-Based Study in Taiwan.

Chen SJ, Kung PT, Huang KH, Wang YH, Tsai WC - PLoS ONE (2015)

Survival curves between treated and delayed/untreated patients of breast cancer at different stages.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4482743&req=5

pone.0131305.g002: Survival curves between treated and delayed/untreated patients of breast cancer at different stages.
Mentions: This study showed that there was significant difference (p <0.05) in overall survival between patients who delayed or refused therapy and those with treatment (Fig 1). The 5-year survival rate was 85% and 45% for patients with treatment and those who delayed or refused therapy, respectively. We also displayed the survival situation at different stages between treated patients and delayed/refused treatment patients in Fig 2. The survival difference between two groups was more significant at stage II and stage III.

Bottom Line: The patients who delayed or refused therapy had lower 5-year overall survival rate compared with the treated group.Our results demonstrated that age and cancer staging were the main patient characteristics affecting whether the patients delayed or refused therapy.The delay or refusal of treatment was associated with the level of diagnosing hospital.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Services Administration, China Medical University, Taichung, Taiwan; Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan.

ABSTRACT

Background: The evidence indicated breast cancer was a cancer with high survival rate. However, there were still some breast cancer patients delaying or refusing therapy. So we conducted a cohort study to explore the relationship between characteristics of breast cancer patients and delay or refusal of therapy within four months after cancer diagnosed.

Methods: This was a retrospective national population-based study from 2004 to 2010 in Taiwan. This study included 35,095 patients with new diagnosis breast cancer from Taiwan Cancer Registry Database. Several analysis methods, including t test, Chi-square test, generalized estimating equations of logistic regression analysis, and Cox proportional hazards model, were performed to explore the characteristics of these patients and the relative risk of mortality with delay or refusal of therapy.

Results: Our study showed that the overall survival rates were significantly different (p <0.05) between the breast cancer patients who delayed or refused therapy and those with treatment. The patients who delayed or refused therapy had lower 5-year overall survival rate compared with the treated group. The related factors included age, Charlson comorbidity index, cancer staging (OR = 1.30-19.69; p <0.05), other catastrophic illnesses or injuries and the level of diagnostic hospitals. However, the patients with different income levels and degree of urbanization in living area were not statistically significant factors.

Conclusion: Our results demonstrated that age and cancer staging were the main patient characteristics affecting whether the patients delayed or refused therapy. The delay or refusal of treatment was associated with the level of diagnosing hospital.

No MeSH data available.


Related in: MedlinePlus