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Anterior Subcutaneous versus Submuscular Transposition of the Ulnar Nerve for Cubital Tunnel Syndrome: A Systematic Review and Meta-Analysis.

Liu CH, Chen CX, Xu J, Wang HL, Ke XB, Zhuang ZY, Lai ZL, Wu ZQ, Lin Q - PLoS ONE (2015)

Bottom Line: The risk ratio (RR) and 95% confidence intervals (CI) were calculated for the clinical improvement in function compared to baseline.Our meta-analysis revealed that no significant difference was observed between two comparison groups in terms of postoperative clinical improvement in those studies (RR 1.04, 95% CI 0.86 to 1.25, P = 0.72).Meanwhile, subgroup analyses by study type and follow-up duration revealed the consistent results with the overall estimate.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Quanzhou Orthopedic-Traumatological Hospital, Fujian University of Traditional Chinese Medical, Quanzhou, Fujian Province, China.

ABSTRACT

Objective: To pool reliable evidences for the optimum anterior transposition technique in the treatment of cubital tunnel syndrome by comparing the clinical efficacy of subcutaneous and submuscular anterior ulnar nerve transposition.

Methods: A comprehensive search was conducted in PubMed MEDLINE, Cochrane Library, EMBASE, Web of Science, OVID AMED, EBSCO and potentially relevant surgical archives. Risk of bias of each included studies was evaluated according to Cochrane Handbook for Systematic Reviews of Interventions. The risk ratio (RR) and 95% confidence intervals (CI) were calculated for the clinical improvement in function compared to baseline. Heterogeneity was assessed across studies, and subgroup analysis was also performed based on the study type and follow-up duration.

Results: Three studies with a total of 352 participants were identified, and the clinically relevant improvement was used as the primary outcomes. Our meta-analysis revealed that no significant difference was observed between two comparison groups in terms of postoperative clinical improvement in those studies (RR 1.04, 95% CI 0.86 to 1.25, P = 0.72). Meanwhile, subgroup analyses by study type and follow-up duration revealed the consistent results with the overall estimate. Additionally, the pre- and postoperative motor nerve conduction velocities were reported in two studies with a total of 326 patients, but we could not perform a meta-analysis because of the lack of concrete numerical value in one study. The quality of evidence for clinical improvement was 'low' or 'moderate' on the basis of GRADE approach.

Conclusions: Based on small numbers of studies with relatively poor methodological quality, the limited evidence is insufficient to identify the optimum anterior transposition technique in the treatment of cubital tunnel syndrome. The results of the present study suggest that anterior subcutaneous and submuscular transposition might be equally effective in patients with ulnar neuropathy at the elbow. Therefore, more high-quality randomized controlled trials with standardized clinical improvement metrics are required to further clarify this topic and to provide reproducible pre- and postoperative objective outcomes.

No MeSH data available.


Related in: MedlinePlus

Review flow diagram.
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pone.0130843.g001: Review flow diagram.

Mentions: A flow diagram that described the details of literature search was presented in Fig 1. A total of 312 potentially relevant literatures (192 from PubMed MEDLINE, 21 from Cochrane Library, 33 from EMBASE, 41 from Web of Science, 12 from OVID AMED, 7 from EBSCO and 6 from other) were identified in our initial electronic search. After removal of duplicated records, 226 literatures were remained. Then we excluded 167 inappropriate literatures by scanning the titles and abstracts. After this, the full text of remaining 59 articles were obtained and assessed for eligibility. 56 of them were further excluded for failure to meet the predefined standard protocol (S2 Table). Finally, two RCTs and one quasi-RCT were selected and analyzed in our study.


Anterior Subcutaneous versus Submuscular Transposition of the Ulnar Nerve for Cubital Tunnel Syndrome: A Systematic Review and Meta-Analysis.

Liu CH, Chen CX, Xu J, Wang HL, Ke XB, Zhuang ZY, Lai ZL, Wu ZQ, Lin Q - PLoS ONE (2015)

Review flow diagram.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4482721&req=5

pone.0130843.g001: Review flow diagram.
Mentions: A flow diagram that described the details of literature search was presented in Fig 1. A total of 312 potentially relevant literatures (192 from PubMed MEDLINE, 21 from Cochrane Library, 33 from EMBASE, 41 from Web of Science, 12 from OVID AMED, 7 from EBSCO and 6 from other) were identified in our initial electronic search. After removal of duplicated records, 226 literatures were remained. Then we excluded 167 inappropriate literatures by scanning the titles and abstracts. After this, the full text of remaining 59 articles were obtained and assessed for eligibility. 56 of them were further excluded for failure to meet the predefined standard protocol (S2 Table). Finally, two RCTs and one quasi-RCT were selected and analyzed in our study.

Bottom Line: The risk ratio (RR) and 95% confidence intervals (CI) were calculated for the clinical improvement in function compared to baseline.Our meta-analysis revealed that no significant difference was observed between two comparison groups in terms of postoperative clinical improvement in those studies (RR 1.04, 95% CI 0.86 to 1.25, P = 0.72).Meanwhile, subgroup analyses by study type and follow-up duration revealed the consistent results with the overall estimate.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Quanzhou Orthopedic-Traumatological Hospital, Fujian University of Traditional Chinese Medical, Quanzhou, Fujian Province, China.

ABSTRACT

Objective: To pool reliable evidences for the optimum anterior transposition technique in the treatment of cubital tunnel syndrome by comparing the clinical efficacy of subcutaneous and submuscular anterior ulnar nerve transposition.

Methods: A comprehensive search was conducted in PubMed MEDLINE, Cochrane Library, EMBASE, Web of Science, OVID AMED, EBSCO and potentially relevant surgical archives. Risk of bias of each included studies was evaluated according to Cochrane Handbook for Systematic Reviews of Interventions. The risk ratio (RR) and 95% confidence intervals (CI) were calculated for the clinical improvement in function compared to baseline. Heterogeneity was assessed across studies, and subgroup analysis was also performed based on the study type and follow-up duration.

Results: Three studies with a total of 352 participants were identified, and the clinically relevant improvement was used as the primary outcomes. Our meta-analysis revealed that no significant difference was observed between two comparison groups in terms of postoperative clinical improvement in those studies (RR 1.04, 95% CI 0.86 to 1.25, P = 0.72). Meanwhile, subgroup analyses by study type and follow-up duration revealed the consistent results with the overall estimate. Additionally, the pre- and postoperative motor nerve conduction velocities were reported in two studies with a total of 326 patients, but we could not perform a meta-analysis because of the lack of concrete numerical value in one study. The quality of evidence for clinical improvement was 'low' or 'moderate' on the basis of GRADE approach.

Conclusions: Based on small numbers of studies with relatively poor methodological quality, the limited evidence is insufficient to identify the optimum anterior transposition technique in the treatment of cubital tunnel syndrome. The results of the present study suggest that anterior subcutaneous and submuscular transposition might be equally effective in patients with ulnar neuropathy at the elbow. Therefore, more high-quality randomized controlled trials with standardized clinical improvement metrics are required to further clarify this topic and to provide reproducible pre- and postoperative objective outcomes.

No MeSH data available.


Related in: MedlinePlus