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Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan.

Chou SH, Tung YC, Lin YS, Wu LS, Lin CP, Liou EJ, Chang CJ, Kung S, Chu PH - PLoS ONE (2015)

Bottom Line: After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis.After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46).No association was found among younger patients ≤ 60 years of age.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.

ABSTRACT

Background: The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.

Methods: From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.

Results: A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46). No association was found among younger patients ≤ 60 years of age.

Conclusions: Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.

No MeSH data available.


Related in: MedlinePlus

The cumulative incidence of major adverse cardiovascular events (MACE) associated with mild and severe treated periodontitis (TP).A. The cumulative incidence of MACE among younger patients (age ≤ 60 years old); B. The cumulative incidence of MACE among older patients (age > 60 years old).
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pone.0130807.g002: The cumulative incidence of major adverse cardiovascular events (MACE) associated with mild and severe treated periodontitis (TP).A. The cumulative incidence of MACE among younger patients (age ≤ 60 years old); B. The cumulative incidence of MACE among older patients (age > 60 years old).

Mentions: Fig 2 shows the cumulative incidence of MACE associated with mild and severe TP groups. Among older patients, those with severe TP were associated with higher cumulative incidence of MACE than those with mild TP (P < 0.01). No association between TP severity and incidence of MACE was presented among younger patients (P = 0.37).


Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan.

Chou SH, Tung YC, Lin YS, Wu LS, Lin CP, Liou EJ, Chang CJ, Kung S, Chu PH - PLoS ONE (2015)

The cumulative incidence of major adverse cardiovascular events (MACE) associated with mild and severe treated periodontitis (TP).A. The cumulative incidence of MACE among younger patients (age ≤ 60 years old); B. The cumulative incidence of MACE among older patients (age > 60 years old).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4482590&req=5

pone.0130807.g002: The cumulative incidence of major adverse cardiovascular events (MACE) associated with mild and severe treated periodontitis (TP).A. The cumulative incidence of MACE among younger patients (age ≤ 60 years old); B. The cumulative incidence of MACE among older patients (age > 60 years old).
Mentions: Fig 2 shows the cumulative incidence of MACE associated with mild and severe TP groups. Among older patients, those with severe TP were associated with higher cumulative incidence of MACE than those with mild TP (P < 0.01). No association between TP severity and incidence of MACE was presented among younger patients (P = 0.37).

Bottom Line: After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis.After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46).No association was found among younger patients ≤ 60 years of age.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.

ABSTRACT

Background: The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.

Methods: From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.

Results: A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46). No association was found among younger patients ≤ 60 years of age.

Conclusions: Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.

No MeSH data available.


Related in: MedlinePlus