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Association between DRD2/ANKK1 TaqIA Polymorphism and Susceptibility with Tourette Syndrome: A Meta-Analysis.

Yuan A, Su L, Yu S, Li C, Yu T, Sun J - PLoS ONE (2015)

Bottom Line: However, past results remain conflicting.Stratification by ethnicity indicated the TaqIA A1 allele was significantly associated with TS in Caucasians (fixed-effect model: OR=1.75, 95%CI = 1.43-2.16; random-effect model: OR=1.69, 95%CI = 1.25-2.28) and in Asians (OR=1.54, 95%CI = 1.12-2.10).A2A2 (dominant model) of this polymorphism revealed a significant association with TS in overall populations and Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, New York, United States of America.

ABSTRACT

Background: Genetic factors are important in the pathogenesis of Tourette syndrome (TS). Notably, Dopamine receptor D2 (DRD2) gene has been suggested as a possible candidate gene for this disorder. Several studies have demonstrated that DRD2/ANKK1 TaqIA polymorphism is associated with an increased risk of developing TS. However, past results remain conflicting. We addressed this controversy by performing a meta-analysis of the relationship between DRD2/ANKK1 TaqIA polymorphism and TS.

Methods: Literature was searched in multiple databases including PUBMED, COCHRANE and WEB OF SCIENCE up to July 2014. The number of the genotypes for DRD2/ANKK1 TaqIA in the TS and control subjects was extracted and statistical analysis was performed using Review Manager 5.0.16 and Stata 12.0 software. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) were utilized to calculate the risk of TS with DRD2/ANKK1 TaqIA. Stratified analysis based on ethnicity was also conducted.

Results: 523 patients with TS, 564 controls and 87 probands plus 152 relatives from five published studies were finally involved in this meta-analysis. Combined analysis revealed that the overall ORs for the DRD2/ANKK1 TaqIA A1 allele were 1.69 (95%CIs = 1.42-2.00) in the fixed-effect model and 1.66 (95%CIs = 1.33-2.08) in the random-effects model. Stratification by ethnicity indicated the TaqIA A1 allele was significantly associated with TS in Caucasians (fixed-effect model: OR=1.75, 95%CI = 1.43-2.16; random-effect model: OR=1.69, 95%CI = 1.25-2.28) and in Asians (OR=1.54, 95%CI = 1.12-2.10). Meta-analysis of the A1A1 vs. A2A2 (homozygous model), A1A2 vs. A2A2 (heterozygous model) and A1A1+A1A2 vs. A2A2 (dominant model) of this polymorphism revealed a significant association with TS in overall populations and Caucasians.

Conclusions: This meta-analysis suggested that the DRD2/ANKK1 TaqIA polymorphism might contribute to TS susceptibility, especially in Caucasian population. However, further investigation with a larger number of worldwide studies should be conducted to verify the association.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the susceptibility of TS associated with DRD2 Taq I polymorphism under stratification (A1A1+A1A2 vs. A2A2).
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pone.0131060.g005: Forest plot of the susceptibility of TS associated with DRD2 Taq I polymorphism under stratification (A1A1+A1A2 vs. A2A2).

Mentions: In both a fixed-effects model and a random-effects model, significantly increased TS risk was found for A1 allele vs A2 allele (fixed-effects model: OR = 1.69, 95%CI = 1.42–2.00; random-effects model: OR = 1.66, 95%CI = 1.33–2.08, Fig 2), for A1A1 vs A2A2 (fixed-effects model: OR = 2.46, 95%CI = 1.45–4.20; random-effects model: OR = 2.52, 95%CI = 1.49–4.26, Fig 3), for A1A2 vs A2A2 (fixed-effects model: OR = 1.89, 95%CI = 1.38–2.58; random-effects model: OR = 1.80, 95%CI = 1.13–2.87, Fig 4), for A1A1+A1A2 vs A2A2 (fixed-effects model: OR = 2.05, 95%CI = 1.52–2.76; random-effects model: OR = 2.04, 95%CI = 1.47–2.82, Fig 5), and for A1A1 vs A1A2 +A2A2 (fixed-effects model: OR = 2.19, 95%CI = 1.44–3.31; random-effects model: OR = 2.20, 95%CI = 1.46–3.32, Fig 6) (Table 3).


Association between DRD2/ANKK1 TaqIA Polymorphism and Susceptibility with Tourette Syndrome: A Meta-Analysis.

Yuan A, Su L, Yu S, Li C, Yu T, Sun J - PLoS ONE (2015)

Forest plot of the susceptibility of TS associated with DRD2 Taq I polymorphism under stratification (A1A1+A1A2 vs. A2A2).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4482493&req=5

pone.0131060.g005: Forest plot of the susceptibility of TS associated with DRD2 Taq I polymorphism under stratification (A1A1+A1A2 vs. A2A2).
Mentions: In both a fixed-effects model and a random-effects model, significantly increased TS risk was found for A1 allele vs A2 allele (fixed-effects model: OR = 1.69, 95%CI = 1.42–2.00; random-effects model: OR = 1.66, 95%CI = 1.33–2.08, Fig 2), for A1A1 vs A2A2 (fixed-effects model: OR = 2.46, 95%CI = 1.45–4.20; random-effects model: OR = 2.52, 95%CI = 1.49–4.26, Fig 3), for A1A2 vs A2A2 (fixed-effects model: OR = 1.89, 95%CI = 1.38–2.58; random-effects model: OR = 1.80, 95%CI = 1.13–2.87, Fig 4), for A1A1+A1A2 vs A2A2 (fixed-effects model: OR = 2.05, 95%CI = 1.52–2.76; random-effects model: OR = 2.04, 95%CI = 1.47–2.82, Fig 5), and for A1A1 vs A1A2 +A2A2 (fixed-effects model: OR = 2.19, 95%CI = 1.44–3.31; random-effects model: OR = 2.20, 95%CI = 1.46–3.32, Fig 6) (Table 3).

Bottom Line: However, past results remain conflicting.Stratification by ethnicity indicated the TaqIA A1 allele was significantly associated with TS in Caucasians (fixed-effect model: OR=1.75, 95%CI = 1.43-2.16; random-effect model: OR=1.69, 95%CI = 1.25-2.28) and in Asians (OR=1.54, 95%CI = 1.12-2.10).A2A2 (dominant model) of this polymorphism revealed a significant association with TS in overall populations and Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, New York, United States of America.

ABSTRACT

Background: Genetic factors are important in the pathogenesis of Tourette syndrome (TS). Notably, Dopamine receptor D2 (DRD2) gene has been suggested as a possible candidate gene for this disorder. Several studies have demonstrated that DRD2/ANKK1 TaqIA polymorphism is associated with an increased risk of developing TS. However, past results remain conflicting. We addressed this controversy by performing a meta-analysis of the relationship between DRD2/ANKK1 TaqIA polymorphism and TS.

Methods: Literature was searched in multiple databases including PUBMED, COCHRANE and WEB OF SCIENCE up to July 2014. The number of the genotypes for DRD2/ANKK1 TaqIA in the TS and control subjects was extracted and statistical analysis was performed using Review Manager 5.0.16 and Stata 12.0 software. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) were utilized to calculate the risk of TS with DRD2/ANKK1 TaqIA. Stratified analysis based on ethnicity was also conducted.

Results: 523 patients with TS, 564 controls and 87 probands plus 152 relatives from five published studies were finally involved in this meta-analysis. Combined analysis revealed that the overall ORs for the DRD2/ANKK1 TaqIA A1 allele were 1.69 (95%CIs = 1.42-2.00) in the fixed-effect model and 1.66 (95%CIs = 1.33-2.08) in the random-effects model. Stratification by ethnicity indicated the TaqIA A1 allele was significantly associated with TS in Caucasians (fixed-effect model: OR=1.75, 95%CI = 1.43-2.16; random-effect model: OR=1.69, 95%CI = 1.25-2.28) and in Asians (OR=1.54, 95%CI = 1.12-2.10). Meta-analysis of the A1A1 vs. A2A2 (homozygous model), A1A2 vs. A2A2 (heterozygous model) and A1A1+A1A2 vs. A2A2 (dominant model) of this polymorphism revealed a significant association with TS in overall populations and Caucasians.

Conclusions: This meta-analysis suggested that the DRD2/ANKK1 TaqIA polymorphism might contribute to TS susceptibility, especially in Caucasian population. However, further investigation with a larger number of worldwide studies should be conducted to verify the association.

No MeSH data available.


Related in: MedlinePlus