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PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies.

Gu Y, Dai QS, Hua RX, Zhang B, Zhu JH, Huang JW, Xie BH, Xiong SQ, Tan GS, Li HP - Genes Cancer (2015)

Bottom Line: However, the conclusions were inconsistent.A similar association was observed for the rs2976392 G>A polymorphism.Further large-scale studies with different ethnicities and subtypes of gastric cancer are required to confirm the results from this meta-analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

ABSTRACT
PSCA gene plays an important role in cell adhesion, proliferation and survival. Increasing studies have focused on the association of PSCA gene rs2294008 C>T and rs2976392 G>A with cancer risk. However, the conclusions were inconsistent. Therefore, we performed a meta-analysis to elucidate whether there is a true association, or artifact. We systematically searched eligible studies from MEDLINE, EMBASE and CBM database. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association. The final analysis included 32 studies consisting of 30028 cases and 38765 controls for the rs2294008 C>T polymorphism, and 14 studies with 8190 cases and 7176 controls for the rs2976392 G>A polymorphism. Consequently, the PSCA rs2294008 C>T polymorphism was significantly associated with increased overall cancer risk. Further stratifications indicated the increased risk was more pronounced for gastric (diffused type and non-gastric cardia adenocarcinoma) and bladder cancer. A similar association was observed for the rs2976392 G>A polymorphism. This meta-analysis demonstrated that both of the PSCA rs2294008 C>T and rs2976392 G>A polymorphisms are associated with increased cancer risk, especially for gastric cancer and bladder cancer. Further large-scale studies with different ethnicities and subtypes of gastric cancer are required to confirm the results from this meta-analysis.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of included studies for the association between PSCA polymorphisms and overall cancer susceptibility
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Figure 1: Flow diagram of included studies for the association between PSCA polymorphisms and overall cancer susceptibility

Mentions: As shown in Figure 1, a total of 136 publications were indentified from PubMed and Embase. Moreover, 10 additional publications were indentified from CBM database. After reviewing the titles and abstracts of the potential available articles, 105 publications were excluded, mainly due to no relevance, reviews, or functional studies. Forty one full-text articles that met the crude inclusion criteria were further evaluated for eligibility. Of them, two studies written in Chinese were excluded because of the overlap of study subjects [22, 32]. Moreover, one investigation was excluded for only focused on gastric survival not case-control study [51], three publications were excluded due to lack of genotyping data [52-54], one was not focused on cancer [55], and another two that did not pertain to either of these two polymorphism were also excluded [56, 57]. Eventually, 32 publications were included in the final meta-analysis.


PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies.

Gu Y, Dai QS, Hua RX, Zhang B, Zhu JH, Huang JW, Xie BH, Xiong SQ, Tan GS, Li HP - Genes Cancer (2015)

Flow diagram of included studies for the association between PSCA polymorphisms and overall cancer susceptibility
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4482246&req=5

Figure 1: Flow diagram of included studies for the association between PSCA polymorphisms and overall cancer susceptibility
Mentions: As shown in Figure 1, a total of 136 publications were indentified from PubMed and Embase. Moreover, 10 additional publications were indentified from CBM database. After reviewing the titles and abstracts of the potential available articles, 105 publications were excluded, mainly due to no relevance, reviews, or functional studies. Forty one full-text articles that met the crude inclusion criteria were further evaluated for eligibility. Of them, two studies written in Chinese were excluded because of the overlap of study subjects [22, 32]. Moreover, one investigation was excluded for only focused on gastric survival not case-control study [51], three publications were excluded due to lack of genotyping data [52-54], one was not focused on cancer [55], and another two that did not pertain to either of these two polymorphism were also excluded [56, 57]. Eventually, 32 publications were included in the final meta-analysis.

Bottom Line: However, the conclusions were inconsistent.A similar association was observed for the rs2976392 G>A polymorphism.Further large-scale studies with different ethnicities and subtypes of gastric cancer are required to confirm the results from this meta-analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

ABSTRACT
PSCA gene plays an important role in cell adhesion, proliferation and survival. Increasing studies have focused on the association of PSCA gene rs2294008 C>T and rs2976392 G>A with cancer risk. However, the conclusions were inconsistent. Therefore, we performed a meta-analysis to elucidate whether there is a true association, or artifact. We systematically searched eligible studies from MEDLINE, EMBASE and CBM database. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association. The final analysis included 32 studies consisting of 30028 cases and 38765 controls for the rs2294008 C>T polymorphism, and 14 studies with 8190 cases and 7176 controls for the rs2976392 G>A polymorphism. Consequently, the PSCA rs2294008 C>T polymorphism was significantly associated with increased overall cancer risk. Further stratifications indicated the increased risk was more pronounced for gastric (diffused type and non-gastric cardia adenocarcinoma) and bladder cancer. A similar association was observed for the rs2976392 G>A polymorphism. This meta-analysis demonstrated that both of the PSCA rs2294008 C>T and rs2976392 G>A polymorphisms are associated with increased cancer risk, especially for gastric cancer and bladder cancer. Further large-scale studies with different ethnicities and subtypes of gastric cancer are required to confirm the results from this meta-analysis.

No MeSH data available.


Related in: MedlinePlus